Effects of collagen/β-tricalcium phosphate bone graft to regenerate bone in critically sized rabbit calvarial defects

Tebyanian, Hamid; Norahan, Mohammad Hadi; Eyni, Hossein; Movahedin, Mansoureh; Mortazavi, Seyed Mohammad Javad; Karami, Ali; Nourani, Mohammad Reza; Baheiraei, Nafiseh

doi:10.1177/2280800018820490

Cited by 30 publications

(34 citation statements)

References 71 publications

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“…The mineralized composite scaffold applied to the critical skull defect model of New Zealand white rabbits, which was fabricated by directly adding β-TCP to COL solution [ 82 ]. The COL/β-TCP scaffolds showed better bone repair effect than pure COL scaffold and significantly improved the differentiation of mesenchymal stem cells to osteoblasts.…”

Section: Fabrication Methods Of Mcssmentioning

confidence: 99%

Bioinspired mineralized collagen scaffolds for bone tissue engineering

Ruan

et al. 2021

Bioactive Materials

174

112

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Successful regeneration of large segmental bone defects remains a major challenge in clinical orthopedics, thus it is of important significance to fabricate a suitable alternative material to stimulate bone regeneration. Due to their excellent biocompatibility, sufficient mechanical strength, and similar structure and composition of natural bone, the mineralized collagen scaffolds (MCSs) have been increasingly used as bone substitutes via tissue engineering approaches. Herein, we thoroughly summarize the state of the art of MCSs as tissue-engineered scaffolds for acceleration of bone repair, including their fabrication methods, critical factors for osteogenesis regulation, current opportunities and challenges in the future. First, the current fabrication methods for MCSs, mainly including direct mineral composite, in-situ mineralization and 3D printing techniques, have been proposed to improve their biomimetic physical structures in this review. Meanwhile, three aspects of physical (mechanics and morphology), biological (cells and growth factors) and chemical (composition and cross-linking) cues are described as the critical factors for regulating the osteogenic feature of MCSs. Finally, the opportunities and challenges associated with MCSs as bone tissue-engineered scaffolds are also discussed to point out the future directions for building the next generation of MCSs that should be endowed with satisfactorily mimetic structures and appropriately biological characters for bone regeneration.

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Section: Fabrication Methods Of Mcssmentioning

confidence: 99%

Bioinspired mineralized collagen scaffolds for bone tissue engineering

Ruan

et al. 2021

Bioactive Materials

174

112

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“…The combined effects of increased mechanical strength and the osteogenic characteristics of β-TCP were shown to improve bone regeneration in rabbit femoral defects, when compared to a pure collagen scaffold. 31 Silk has had a long history of use as a biomaterial. 32 It is highly utilized in the field of biomaterials as it has the ability to absorb and release water easily, demonstrates excellent mechanical strength, and has a resistance to ultraviolet (UV) and oxidation, thereby providing a versatility for its sterilization.…”

Section: Natural Polymersmentioning

confidence: 99%

Section: Biomaterialsmentioning

confidence: 99%

An introduction to bone tissue engineering

Rider²,

et al. 2019

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Bone tissue has the capability to regenerate itself; however, defects of a critical size prevent the bone from regenerating and require additional support. To aid regeneration, bone scaffolds created out of autologous or allograft bone can be used, yet these produce problems such as fast degradation rates, reduced bioactivity, donor site morbidity or the risk of pathogen transmission. The development of bone tissue engineering has been used to create functional alternatives to regenerate bone. This can be achieved by producing bone tissue scaffolds that induce osteoconduction and integration, provide mechanical stability, and either integrate into the bone structure or degrade and are excreted by the body. A range of different biomaterials have been used to this end, each with their own advantages and disadvantages. This review will introduce the requirements of bone tissue engineering, beginning with the regeneration process of bone before exploring the requirements of bone tissue scaffolds. Aspects covered include the manufacturing process as well as the different materials used and the incorporation of bioactive molecules, growth factors and cells.

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“…Calcium and phosphate ion release is necessary for bone mineralization – Ca 2+ and PO 4 3− ions regulate bone resorption and bone deposition [ 18 , 26 ]. Furthermore, keeping the bone scaffold similar to that of natural bone provides a desirable environment for cell attachment and proliferation [ 27 ]. The degradation rate of the ideal bone graft should be at the same rate as new bone forms [ 26 ], which is a crucial challenge [ 12 ].…”

Section: Introductionmentioning

confidence: 99%