Effects of colchicine on pericardial diseases: a review of the literature and current evidence

Shah, Syed Raza; Alweis, Richard; Shah, Syed Muhammad Ismail; Arshad, Mohammad Hussham; Manji, Adil Al‐Karim; Arfeen, Arham Amir; Javed, Maheen; Shujauddin, Syed Muhammad; Irfan, Rida; Shabbir, Sakina; Shaikh, Shehryar

doi:10.3402/jchimp.v6.31957

Cited by 16 publications

(9 citation statements)

References 33 publications

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“…[12] It remains the gold standard for the treatment of multivessel and left main coronary artery disease. [3] Since the beginning of 1980s, internal mammary artery (IMA) has been used for CABG.…”

Section: Introductionmentioning

confidence: 99%

Topical vasodilator response in skeletonized internal mammary artery: Is there really a difference?

Shah¹,

Shah²,

Jangda³

et al. 2017

Avicenna J Med

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Aim of the Study:Coronary artery bypass graft surgery is the gold standard for the treatment of multivessel and left main coronary artery disease. However, there is considerable debate that whether left internal mammary artery (IMA) should be taken as pedicled or skeletonized. This study was conducted to assess the difference in blood flow after the application of topical vasodilator in skeletonized and pedicled IMA.Materials and Methods:In this study, each patient underwent either skeletonized (n = 25) or pedicled IMA harvesting (n = 25). The type of graft on each individual patient was decided randomly. Intraoperative variables such as conduit length and blood flow were measured by the surgeon himself. The length of the grafted IMA was carefully determined in vivo, with the proximal and distal ends attached, from the first rib to IMA divergence. The IMA flow was measured on two separate occasions, before and after application of topical vasodilator. Known cases of subclavian artery stenosis and previous sternal radiation were excluded from the study.Results:The blood flow before the application of topical vasodilator was similar in both the groups (P = 0.227). However, the flow was significantly less in pedicled than skeletonized IMA after application of vasodilator (P < 0.0001). Similarly, the length of skeletonized graft was significantly higher than the length of pedicled graft (P < 0.0001).Conclusion:Our study signifies that skeletonization of IMA results in increased graft length and blood flow after the application of topical vasodilator. However, we recommend that long-term clinical trials should be conducted to fully determine long-term patency rates of skeletonized IMA.

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Section: Introductionmentioning

confidence: 99%

Topical vasodilator response in skeletonized internal mammary artery: Is there really a difference?

Shah¹,

Shah²,

Jangda³

et al. 2017

Avicenna J Med

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“…It acts by microtubule depolymerization and tubulin binding, inhibiting the NLRP3 inflammasome protein complex [28,29]. By monocyte caspase-1 inhibition, it brings about inhibition of colocalization of inflammasome cytoplasmic proteins and inhibition of P2 * 7-mediated pore function, a key step in the NLRP3 response to adenosine triphosphate [30][31][32]. In patients with acute coronary syndrome, the monocytes exhibited a reduction in secreted levels of IL-1β after they received a low dose of colchicine.…”

Section: Role Of Colchicinementioning

confidence: 99%

Is There a Role for Colchicine in Acute Coronary Syndromes? A Literature Review

Malik

Javed

Ishaq

et al. 2020

Cureus

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Inflammation is identified as a keystone of atherosclerosis. This review of the literature explores the unique anti-inflammatory effects of colchicine and summarizes the mechanisms of inflammation in acute coronary syndrome. It outlines other therapeutic strategies employed until now to target coronary inflammation and analyzes the role of colchicine in improving the outcomes of acute coronary syndrome. Despite the existence of guideline-directed medical therapy, there still remains a higher risk for recurrence due to continuous inflammation at remaining vascular sites. Several anti-inflammatory strategies have been employed, but they have not been shown to be beneficial. However, colchicine is becoming increasingly popular in tackling this problem. For this review, databases were searched for trials on the role of colchicine as an anti-inflammatory therapy in acute coronary syndrome.

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“…3 There are no proven effective medical treatments of pericardial effusions without inflammation, but, when the pericardial effusion is associated with pericarditis, management should follow that of pericarditis. 3 Currently, there is a growing body of evidence of a beneficial effect of Colchicine in preventing recurrent pericardial effusion in pericarditis and postpericardiotomy syndrome, [10][11][12][13][14] whereas Colchicine is not…”

Section: Introductionmentioning

confidence: 99%

Occurrence and predictors of pericardial effusion requiring invasive treatment following heart valve surgery

et al. 2022

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ObjectivesTo describe the occurrence of significant pericardial effusion, and to investigate characteristics associated with pericardial effusion within three months following heart valve surgery.MethodsA retrospective, observational cohort study including adult patients undergoing heart valve surgery at Odense University Hospital from August 2013 to November 2017. Data were gathered from The Western Denmark Heart Registry and electronic patient records.Cox proportional hazard models were used to investigate the associations between characteristics associated with significant pericardial effusion during index admission and within 3 months. Results are presented as HR with 95% CI.ResultsIn total, 1460 patients were included (70% men, median age 71 years (IQR 63–76)) and of those, n=230 patients (16%) developed significant pericardial effusion.EuroScore II was significantly associated with an increased risk of pericardial effusion during index admission and associated with a lower risk following discharge (index admission HR 1.05, 95% CI 1.02 to 1.08, after discharge HR 0.80, 95% CI 0.69 to 0.92). Increasing age (HR 0.97, 95% CI 0.95 to 0.98 per year) and concomitant coronary artery bypass grafting versus isolated valve surgery (HR 0.58, 95% CI 0.35 to 0.97) were significantly associated with a reduced risk of pericardial effusions in both periods. Being a man (HR 2.30, 95% CI 1.32 to 4.01) and aortic valve disease versus mitral valve disease (HR 2.16, 95% CI 1.20 to 3.90) were significantly associated with an increased risk after discharge.ConclusionSignificant pericardial effusions requiring drainage were present in 16% of cases following heart valve surgery, and different clinical characteristics were associated with the development of effusion.

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Effects of colchicine on pericardial diseases: a review of the literature and current evidence

Cited by 16 publications

References 33 publications

Topical vasodilator response in skeletonized internal mammary artery: Is there really a difference?

Topical vasodilator response in skeletonized internal mammary artery: Is there really a difference?

Is There a Role for Colchicine in Acute Coronary Syndromes? A Literature Review

Occurrence and predictors of pericardial effusion requiring invasive treatment following heart valve surgery

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