Effects of colchicine on myofilament arrangement and the lysosomal system in skeletal muscle

Colchicine is used in the treatment of gouty arthritis, familial Mediterranean fever, amyloidosis, Behcet disease and dermatoses. Myoneuropathy is a rare side-eect reported either with intoxication or in elderly patients with chronic renal insuciency causing elevated plasma drug levels. We report the ®rst two cases of myoneuropathy in children, both taking appropriate doses of colchicine, and having normal renal function. The myoneuropathic changes were reversible after stopping treatment. The cause of colchicine myoneuropathy is unclear. Conclusion In children treated with colchicine, neuromuscular phenomena of unknown aetiology may be related to the drug, even with a lack of intoxication or renal insuciency.

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“…Colchicine causes a characteristic myopathy in animals [13]. Myopathy associated with its long-term use in humans has been rarely reported.…”

Section: Discussionmentioning

confidence: 99%

Colchicine-induced myoneuropathy in childhood

Harel

Mukamel

Amir

et al. 1998

European Journal of Pediatrics

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“…Comment: Round cytoplasmic basophilic bodies of up to 3µm in diameter composed ultrastructurally of laminated membranous material (spheromembranous bodies) have been described in the muscles of rats treated with agents such as vincristine, colchicine and chloroquine ( 103 Slotwiner et al 1966; 20 Clarke et al 1972; 100 Seiden 1973; 10 Bradley et al 1976).…”

Section: Morphologymentioning

confidence: 99%

Proliferative and Non-Proliferative Lesions of the Rat and Mouse Soft Tissue, Skeletal Muscle and Mesothelium

et al. 2013

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The INHAND Project (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice) is a joint initiative of the Societies of Toxicologic Pathology from Europe (ESTP), Great Britain (BSTP), Japan (JSTP), and North America (STP) to develop an internationally accepted nomenclature for proliferative and nonproliferative lesions in laboratory animals. The purpose of this publication is to provide a standardized nomenclature for classifying lesions observed in the soft tissues including skeletal muscle as well as the mesothelium of rats and mice. The standardized nomenclature of lesions presented in this document is also available electronically on the Internet (http://www.goreni.org/). Sources of material included histopathology databases from government, academia, and industrial laboratories throughout the world. Content includes spontaneous developmental and aging lesions as well as those induced by exposure to test materials. A widely accepted and utilized international harmonization of nomenclature for lesions in soft tissues, skeletal muscle and mesothelium in laboratory animals will decrease confusion among regulatory and scientific research organizations in different countries and provide a common language to increase and enrich international exchanges of information among toxicologists and pathologists. (DOI: 10.1293/tox.26.1S; J Toxicol Pathol 2013; 26: 1S–26S)

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“…While myopathy has been observed experimentally in skeletal muscle, 9,10 and also documented in humans, 3À8 neuropathologic documentation has been available from just 2 patients. 4,5 While there is a good clinical description of neuropathy in patients taking 1.2 mg of colchicine daily for 2 or more years, 5 an experimental model for colchicine neuropathy is lacking.…”

Section: à8mentioning

confidence: 98%