Effects of cognitive versus motor dual-task on spatiotemporal gait parameters in healthy controls and multiple sclerosis patients with and without fall history

Mofateh, Razieh; Salehi, Reza; Negahban, Hossein; Mehravar, Mohammad; Tajali, Shirin

doi:10.1016/j.msard.2017.09.002

Cited by 17 publications

(17 citation statements)

References 68 publications

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“…To get familiarized with the treadmill walking and also obtain the preferred speed, participants were asked to walk for 5 min before commencing the test procedure. They were asked to walk on the treadmill commencing at 0.8 km/h, gradually increasing the speed by 0.1 km/h until they report their preferred speed (Mofateh et al, 2017). The speed of the treadmill was again increased and decreased in 0.1 km/h intervals to reconfirm the preferred speed (Mofateh et al, 2017).…”

Section: Methodsmentioning

confidence: 99%

“…They were asked to walk on the treadmill commencing at 0.8 km/h, gradually increasing the speed by 0.1 km/h until they report their preferred speed (Mofateh et al, 2017). The speed of the treadmill was again increased and decreased in 0.1 km/h intervals to reconfirm the preferred speed (Mofateh et al, 2017). Participants were given enough rest before the actual experiment.…”

Section: Methodsmentioning

confidence: 99%

“…Therefore, the purpose of the current study was to prospectively assess the predictive ability of LDS of walking and its dual task costs (DTCs) to identify fall risk in PwMS. Based on the current available evidences (Learmonth et al, 2016;Mofateh et al, 2017;Tajali et al, 2017;Wajda and Sosnoff, 2015), it was hypothesized that LyE and their dual task costs (DTCs) can predict future falls in PwMS. Information obtained from this study will help clinicians to prescribe fall treatment and prevention programs based on the underlying gait deficits in the single or dual task conditions.…”

Section: Introductionmentioning

confidence: 99%

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Impaired local dynamic stability during treadmill walking predicts future falls in patients with multiple sclerosis: A prospective cohort study

Tajali

Mehravar

Negahban

et al. 2019

Clinical Biomechanics

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Background: Falling is a significant problem in patients with multiple sclerosis (MS) and the majority of falls occur during dynamic activities. Recently, there have been evidences focusing on falls and local stability of walking based on dynamic system theory in the elderly as well as patients with cerebral concussion. However, in patient with MS, this relationship has not been fully investigated. The aim of this study was to investigate local stability of walking as a risk factor for falling in patients with MS. Methods: Seventy patients were assessed while walking at their preferred speed on a treadmill under single and dual task conditions. A cognitive task (backward counting) was used to assess the importance of dual tasking to fall risk. Trunk kinematics were collected using a cluster marker over the level of T 7 and a 7-camera motion capture system. To quantify local stability of walking, maximal finite-time Lyapunov exponent was calculated from a 12-dimensional state space reconstruction based on 3-dimensional trunk linear and angular velocity time series. Participants were classified as fallers (≥1) and non-fallers based on their prospective fall occurrence. Findings: 30 (43%) participants recorded ≥1 falls and were classified as fallers. The results of multiple logistic regression analysis revealed that short-term local dynamic stability in the single task condition (P < 0.05, odds ratio = 2.214 (1.037-4.726)) was the significant fall predictor. Interpretation: The results may indicate that the assessment of local stability of walking can identify patients who would benefit from gait retraining and fall prevention programs.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Impaired local dynamic stability during treadmill walking predicts future falls in patients with multiple sclerosis: A prospective cohort study

Tajali

Mehravar

Negahban

et al. 2019

Clinical Biomechanics

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“…There is some preliminary evidence for cross-modality transfer effects regarding exercise training in MS ( Motl and McAuley, 2014 ; Sandroff et al, 2014 , 2017 ). For instance, studies on aerobic exercise training and on physical activity interventions reported co-occurring improvements in cognitive and motor outcomes ( Mofateh et al, 2017 ). In particular, the cognitive training combined with the aerobic exercises proved effective to improve cognitive performance ( Jimenez-Morales et al, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

Integrated Cognitive and Neuromotor Rehabilitation in Multiple Sclerosis: A Pragmatic Study

Barbarulo

Lus

Signoriello

et al. 2018

Front. Behav. Neurosci.

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Background: Few studies examined the effects of combined motor and cognitive rehabilitation in patients with multiple sclerosis (MS). The present prospective, multicenter, observational study aimed to determine the efficacy of an integrated cognitive and neuromotor rehabilitation program versus a traditional neuromotor training on walking, balance, cognition and emotional functioning in MS patients.Methods: Sixty three MS patients were selected and assigned either to the Integrated Treatment Group (ITG; n = 32), receiving neuropsychological treatment (performed by ERICA software and paper–pencil tasks) complemented by conventional neuromotor rehabilitation, or to the Motor Treatment Group (n = 31) receiving neuromotor rehabilitation only. The intervention included two 60-min sessions per week for 24 weeks. At baseline and at end of the training all patients underwent a wide-range neuropsychological, psychological/emotional, and motor assessment.Results: At baseline the two groups did not differ for demographic, neuropsychological, psychological/emotional, and motor features significantly. After rehabilitation, only ITG group significantly (p-corrected for False Discovery Rate) improved on test tapping spatial memory, attention and cognitive flexibility, as well as on scales assessing depression and motor performance (balance and gait). A regression analysis showed that neuropsychological and motor improvement was not related to improvements in fatigue and depression.Conclusion: The present study demonstrated positive effects in emotional, motor, and cognitive aspects in MS patients who received an integrated cognitive and neuromotor training. Overall, results are supportive of interventions combining motor and cognitive training for MS.

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“…Gait variability has been shown to differentiate between both individuals with MS and healthy controls and MS fallers and non-fallers [44], as well as being linked to disability level, fatigue, and attention in persons with MS [45]. Therefore, the association between SMA DTI measures with gait variability (CVs) is particularly relevant, and represents a novel finding among persons with MS. A recent imaging study demonstrated relationships among increased gait variability and lower hippocampal and putamen volumes in MS fallers, but no DTI measures or tract-specific imaging was performed [46].…”

Section: Discussionmentioning

confidence: 99%

Supplementary motor area connectivity and dual-task walking variability in multiple sclerosis

Fritz

Kloos

Kegelmeyer

et al. 2019

Journal of the Neurological Sciences

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Background.-Despite the prevalence of dual-task (e.g., walking while talking) deficits in people with multiple sclerosis (MS), no neuroimaging studies to date have examined neuronal networks used for dual-task processing or specific brain areas related to dual-task performance in this population. A better understanding of the relationship among underlying brain areas and dualtask performance may improve targeted rehabilitation programs. The objective of this study was to examine relationships between neuroimaging measures and clinical measures of dual-task performance, and reported falls in persons with MS. Materials and methods.-All participants completed measures of dual-task performance, a fall history, and neuroimaging on a 3T MRI scanner. Spearman correlations were used to examine relationships among dual-task performance, falls and neuroimaging measures. Results.-Eighteen females with relapsing-remitting MS [mean age= 45.5 ± 8.2 SD; mean symptom duration = 12.3±6.7 years; Expanded Disability Status Scale median 2.25 (range 1.5-4)] participated in this study. Structural imaging measures of supplementary motor area (SMA) interhemispheric connectivity were significantly related to dual-task walking variability. Conclusions.-The SMA interhemispheric tract may play a role in dual-task performance. Structural neuroimaging may be a useful adjunct to clinical measures to predict performance and provide information about recovery patterns in MS. Functional recovery can be challenging to *

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Effects of cognitive versus motor dual-task on spatiotemporal gait parameters in healthy controls and multiple sclerosis patients with and without fall history

Cited by 17 publications

References 68 publications

Impaired local dynamic stability during treadmill walking predicts future falls in patients with multiple sclerosis: A prospective cohort study

Impaired local dynamic stability during treadmill walking predicts future falls in patients with multiple sclerosis: A prospective cohort study

Integrated Cognitive and Neuromotor Rehabilitation in Multiple Sclerosis: A Pragmatic Study

Supplementary motor area connectivity and dual-task walking variability in multiple sclerosis

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