Effects of coexposure to noise and mixture of toluene, ethylbenzene, xylene, and styrene (TEXS) on hearing loss in petrochemical workers of southern China

Zhang, Yan; Liu, Yan; Li, Zongxin; Liu, Xin; Chen, Qingfei; Qin, Jingyao; Liao, Qilong; Du, Rui; Deng, Qifei; Xiao, Yongmei; Xing, Xiumei

doi:10.1007/s11356-022-24414-6

Cited by 4 publications

(1 citation statement)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Additionally, combined exposure to toluene and ethylbenzene leads to enhanced outer hair cell death, resulting in auditory function loss [ 45 , 46 ]. Previous investigations have explored the occupational risks of toluene, ethylbenzene, xylene, and styrene (TEXS) exposure concerning hearing loss among petrochemical workers [ 47 ]. Other studies have found an association between organic solvents (benzene, toluene, and xylene) and the incidence of high-frequency hearing loss [ 48 ].…”

Section: Discussionmentioning

confidence: 99%

Association between blood volatile organic aromatic compound concentrations and hearing loss in US adults

Wang,

Luo,

Zhang

et al. 2024

BMC Public Health

View full text Add to dashboard Cite

Objective Benzene, ethylbenzene, meta/para-xylene, and ortho-xylene, collectively referred to as benzene, ethylbenzene, and xylene (BEX), constitute the main components of volatile organic aromatic compounds (VOACs) and can have adverse effects on human health. The relationship between exposure to BEX and hearing loss (HL) in the adult U.S. population was aimed to be assessed. Methods Cross-sectional data from the National Health and Nutrition Examination Survey (NHANES) for the years 2003–2004, 2011–2012, and 2015–2016 were analyzed. This dataset included complete demographic characteristics, pure-tone audiometry measurements, and volatile organic compound detection data from the NHANES database. A weighted multivariate logistic regression model was employed to investigate the associations between blood BEX concentrations HL, low-frequency hearing loss (SFHL), and high-frequency hearing loss (HFHL). Results 2174 participants were included, with weighted prevalence rates of HL, SFHL, and HFHL being 46.81%, 25.23%, and 45.86%, respectively. Exposure to benzene, ethylbenzene, meta/para-xylene, and ortho-xylene, and cumulative BEX concentrations increased the risk of hearing loss (odds ratios [ORs] were 1.36, 1.22, 1.42, 1.23, and 1.31, respectively; all P < 0.05). In the analysis with SFHL as the outcome, ethylbenzene, m-/p-xylene, o-xylene, benzene, and overall BEX increased the risk (OR 1.26, 1.21, 1.28, 1.20, and 1.25, respectively; all P < 0.05). For HFHL, exposure to ethylbenzene, m-/p-xylene, o-xylene, benzene, and overall BEX increased the risk (OR 1.36, 1.22, 1.42, 1.22, and 1.31, respectively; all P < 0.05). Conclusion Our study indicated that a positive correlation between individual or cumulative exposure to benzene, ethylbenzene, meta/para-xylene, and ortho-xylene and the risk of HL, SFHL, and HFHL. Further research is imperative to acquire a more comprehensive understanding of the mechanisms by which organic compounds, notably BEX, in causing hearing loss and to validate these findings in longitudinal environmental studies.

show abstract

Section: Discussionmentioning

confidence: 99%