Effects of coenzyme Q10 supplementation on glycemic control: A GRADE-assessed systematic review and dose-response meta-analysis of randomized controlled trials

Li, Ying; Zhao, Dan; Ji, Qiuhua; Liu, Meitong; Dai, Suming; Hou, Shanshan; Liu, Zhihao; Mao, Yu-Heng; Tian, Zezhong; Yang, Yan

doi:10.1016/j.eclinm.2022.101602

Cited by 8 publications

(9 citation statements)

References 75 publications

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“…It aligns with another study's results, indicating a significant negative correlation between CoQ10 and HbA1C concentrations [233]. However, data regarding its effect on fasting glucose, fasting insulin, and HOMA-IR are found to have low certainty of the evidence (GRADE Evidence Profile) because of inconsistency, indirectness, and publication bias [237]. This means that the positive impact of CoQ10 supplementation on the above factors cannot be confirmed with certainty, but these results should be taken into consideration, especially in the context of further research.…”

Section: Folic Acidsupporting

confidence: 80%

Immunomodulation through Nutrition Should Be a Key Trend in Type 2 Diabetes Treatment

Napiórkowska-Baran,

Treichel,

Czarnowska

et al. 2024

IJMS

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An organism’s ability to function properly depends not solely on its diet but also on the intake of nutrients and non-nutritive bioactive compounds that exert immunomodulatory effects. This principle applies both to healthy individuals and, in particular, to those with concomitant chronic conditions, such as type 2 diabetes. However, the current food industry and the widespread use of highly processed foods often lead to nutritional deficiencies. Numerous studies have confirmed the occurrence of immune system dysfunction in patients with type 2 diabetes. This article elucidates the impact of specific nutrients on the immune system function, which maintains homeostasis of the organism, with a particular emphasis on type 2 diabetes. The role of macronutrients, micronutrients, vitamins, and selected substances, such as omega-3 fatty acids, coenzyme Q10, and alpha-lipoic acid, was taken into consideration, which outlined the minimum range of tests that ought to be performed on patients in order to either directly or indirectly determine the severity of malnutrition in this group of patients.

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Section: Folic Acidsupporting

confidence: 80%

Immunomodulation through Nutrition Should Be a Key Trend in Type 2 Diabetes Treatment

Napiórkowska-Baran,

Treichel,

Czarnowska

et al. 2024

IJMS

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“…It is worth noting that in the recent meta-analyses on the relationship between CoQ10 and blood pressure, blood glucose and oxidative biomarkers, the optimal supplementary dose of CoQ10 was considered to be 100-200 mg d −1 . [56][57][58] This difference suggested that improving the inflammatory status of body may require a higher dose of CoQ10 supplement than improving blood pressure, blood glucose, or oxidative stress, and it also indicated that the anti-inflammatory effect might not be the main direct effect of CoQ10. In addition, CoQ10 supplementation is tolerated, even up to 1200 mg d −1 .…”

Section: Discussionmentioning

confidence: 99%

Efficacy and Optimal Dose of Coenzyme Q10 Supplementation on Inflammation‐Related Biomarkers: A GRADE‐Assessed Systematic Review and Updated Meta‐Analysis of Randomized Controlled Trials

Hou

Tian

Zhao

et al. 2023

Molecular Nutrition Food Res

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Scope: Coenzyme Q10 (CoQ10) has become a popular nutritional supplement due to its wide range of beneficial biological effects. Previous meta-analyses show that the attenuation of CoQ10 on inflammatory biomarkers remains controversial. This meta-analysis aims to assess the efficacy and optimal dose of CoQ10 supplementation on inflammatory indicators in the general population. Methods and results: Databases are searched up to December 2022 resulting in 6713 articles, of which 31 are retrieved for full-text assessment and included 1517 subjects. Double-blind randomized controlled trials (RCTs) of CoQ10 supplementation are eligible if they contain C reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-𝜶 (TNF-𝜶). CoQ10 supplementation can significantly reduce the levels of circulating CRP (SMD: −0.40, 95% CI: [−0.67 to −0.13], p = 0.003), IL-6 (SMD: −0.67, 95% CI: [−1.01 to −0.33], p < 0.001), and TNF-𝜶 (SMD: −1.06, 95% CI: [−1.59 to −0.52], p < 0.001) and increase the concentration of circulating CoQ10. Conclusion: This meta-analysis provides evidence for CoQ10 supplementation to reduce the level of inflammatory mediators in the general population and proposes that daily supplementation of 300-400 mg CoQ10 show superior inhibition of inflammatory factors.

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“…As a result, CoQ10 supplementation may contribute to enhanced health outcomes in this population. The anti-inflammatory characteristic of CoQ10 may potentially contribute to the prevention or mitigation of specific diabetes consequences, including cardiovascular illnesses (41).…”

Section: Benefits Of Coq10 In Managing Diabetesmentioning

confidence: 99%

“…Investigations have been dedicated to ascertaining the most advantageous dosage and effectiveness of CoQ10 in the context of persons afflicted with diabetes. According to existing research, the provision of a daily supplement ranging from 100 to 200 mg of CoQ10 has been found to have a notable positive impact on glycemic management and the overall metabolic profile of individuals diagnosed with type 2 diabetes (41). The efficacy of CoQ10 is evidenced by its ability to enhance insulin sensitivity, mitigate oxidative stress, and improve beta-cell function.…”

Section: The Optimal Dosage and Efficacy Of Coq10 For Diabetesmentioning

confidence: 99%

Coenzyme Q10: A Ubiquitous Supplemental Enzyme Contributing to the Health

Silić

2023

Sci Insights

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Coenzyme Q10 (CoQ10) is an endogenous molecule that is ubiquitously found throughout the cellular composition of the human organism. The aforementioned substance plays a crucial function in the production of energy and serves as a potent antioxidant, safeguarding cells against harm induced by free radicals. As individuals progress in age, there is a tendency for the amounts of CoQ10 in their bodies to diminish, resulting in a range of health consequences. Research has indicated that the addition of CoQ10 through supplementation can yield a multitude of advantageous outcomes. Research has demonstrated that it can enhance energy production in cardiac cells and mitigate oxidative stress, so contributing to the improvement of heart health. Furthermore, CoQ10 has demonstrated potential in the management of several illnesses such as hypertension, migraines, and fibromyalgia, attributed to its capacity to enhance mitochondrial activity and alleviate inflammation. Moreover, existing research indicates that the utilization of this particular coenzyme may potentially enhance fertility through the improvement of sperm quality, as well as contribute to the maintenance of good skin by facilitating collagen synthesis. Notwithstanding these possible advantages, it is essential to get guidance from a healthcare practitioner prior to commencing any supplementation protocol due to the potential variability of individual requirements.

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Effects of coenzyme Q10 supplementation on glycemic control: A GRADE-assessed systematic review and dose-response meta-analysis of randomized controlled trials

Cited by 8 publications

References 75 publications

Immunomodulation through Nutrition Should Be a Key Trend in Type 2 Diabetes Treatment

Immunomodulation through Nutrition Should Be a Key Trend in Type 2 Diabetes Treatment

Efficacy and Optimal Dose of Coenzyme Q10 Supplementation on Inflammation‐Related Biomarkers: A GRADE‐Assessed Systematic Review and Updated Meta‐Analysis of Randomized Controlled Trials

Coenzyme Q10: A Ubiquitous Supplemental Enzyme Contributing to the Health

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