Effects of Coenzyme Q10 Supplementation on Inflammatory Cytokines (TNF-α, IL-6) and Oxidative Stress in Rheumatoid Arthritis Patients: A Randomized Controlled Trial

Abdollahzad, Hadi; Aghdashi, Mir Amir; Jafarabadi, Mohammad Asghari; Alipour, Beitullah

doi:10.1016/j.arcmed.2015.08.006

Cited by 83 publications

(73 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Specifically, in chronic conditions related to the overproduction and over‐activity of pro‐inflammatory cytokines, CoQ10 supplementation resulted in the attenuation of inflammatory markers and prevented the activation of inflammatory signaling pathways. For example, among patients with rheumatoid arthritis, investigators found that TNF‐alpha was suppressed after two months of CoQ10 supplementation as compared to placebo . In another trial of multiple sclerosis patients treated with CoQ10, subjects who received CoQ10 therapy had both lower levels of TNF‐alpha and IL‐6 compared to placebo after 12 weeks .…”

Section: Discussionmentioning

confidence: 99%

“…[22][23][24] Specifically, the inflammatory cytokines IL-6 and TNF-alpha have been vestigators found that TNF-alpha was suppressed after two months of CoQ10 supplementation as compared to placebo. 30 In another trial of multiple sclerosis patients treated with CoQ10, subjects who received CoQ10 therapy had both lower levels of TNF-alpha and IL-6 compared to placebo after 12 weeks. 31 Given the potential anti-oxidative and antiinflammatory capacity of CoQ10, we expected our finding of low levels of CoQ10 to be associated with an increase in inflammatory markers.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Coenzyme Q10 in acute influenza

Chase

Cocchi

Liu

et al. 2018

Influenza Resp Viruses

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Coenzyme Q10 in acute influenza

Chase

Cocchi

Liu

et al. 2018

Influenza Resp Viruses

View full text Add to dashboard Cite

show abstract

“…20,21 Several experimental studies have demonstrated that controlled O 3 administration could prevent the damage of reactive oxygen species. [5][6][7] Although the etiopathogenesis of RA has not been fully identified yet, oxidative stress plays an important role in its underlying pathogenesis. 11,[22][23][24] MDA, the oxidation product, is considered an index of lipid oxidation.…”

Section: Discussionmentioning

confidence: 99%

“…Arthritis severity was evaluated by an experienced observer using an arthritis index according to the standardized method. 7 The arthritis index was scored from 0 to 4 points as follows: 0: no evidence of hyperemia and/or inflammation; 1: hyperemia with little or no paw swelling; 2: swelling confined predominantly to the ankle region, with modest hyperemia; 3: increased paw swelling and hyperemia of the ankle and metatarsal regions; 4: maximal paw swelling and hyperemia involving the ankle, metatarsal, and tarsal regions.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Effect of Ozone in Freund’s Complete Adjuvant-Induced Arthritis

et al. 2018

View full text Add to dashboard Cite

Objectives: This study aims to investigate the effectiveness and reliability of ozone (O3) in Freund's complete adjuvant (FCA)-induced arthritis, an animal model for rheumatoid arthritis (RA). Materials and methods: Thirty-six four-to five-month-old male Wistar rats weighing between 274-420 gr were used in this study. Saline was injected into the hind paws of half of these rats, and FCA was injected into the other half. At the end of two weeks, 40 µg of O3 was administered to nine rats from each group twice a week for seven total doses. The rats were followed-up in terms of clinical findings. At the sixth week, the rats were sacrificed and serum malondialdehyde, glutathione peroxidase, and superoxide dismutase levels were measured. In addition, ankle joints were separated for histopathological examination. Results: Significant improvement was observed in terms of hind-paw diameter, severity of arthritis, and histopathological findings of inflammation after O3 treatment in the group with FCA-induced arthritis. Although it was not quite significant, an upward trend was detected in oxidative stress markers with O3 treatment. Conclusion: This study, the first to investigate the effects of systemic O3 on the clinical and histopathological outcomes of RA, indicates that O3 is a highly effective and reliable treatment method in FCA-induced arthritis in animal models.

show abstract

Coenzyme Q10 Prevents the Interleukin‐1 Beta Induced Inflammatory Response via Inhibition of MAPK Signaling Pathways in Rat Articular Chondrocytes

Guo

Huang

et al. 2017

Drug Development Research

View full text Add to dashboard Cite

Preclinical Research Osteoarthritis (OA) is a widely prevalent degenerative joint disease that severely impairs the health of the elderly population resulting in a heavy economic burden worldwide. Coenzyme Q10 (CoQ10) has shown anti-inflammatory effects in some diseases. The present study aimed to investigate if CoQ10 would suppress catabolic responses of interleukin (IL)-1β-induced chondrocytes. Rat chondrocytes were cultured and pretreated with CoQ10, and then stimulated with or without IL-1β (10 ng/ml). The expression and production of matrix metalloproteinase (MMP)-3, MMP-9, and MMP13 were determined using real-time PCR and Western blotting. CoQ10 suppressed MMP-3, MMP-9, and MMP13 production induced by IL-1β, and markedly inhibited IL-1β-induced MAPK pathways in rat chondrocytes. The present study provides insight into potential mechanisms by which CoQ10 protects against degeneration of cartilage in patients with OA, which may lead to new approaches for the treatment of OA.Drug Dev Res 78 : 403-410, 2017. © 2017 Wiley Periodicals, Inc.

show abstract

Effects of Coenzyme Q10 Supplementation on Inflammatory Cytokines (TNF-α, IL-6) and Oxidative Stress in Rheumatoid Arthritis Patients: A Randomized Controlled Trial

Cited by 83 publications

References 40 publications

Coenzyme Q10 in acute influenza

Coenzyme Q10 in acute influenza

Effect of Ozone in Freund’s Complete Adjuvant-Induced Arthritis

Coenzyme Q10 Prevents the Interleukin‐1 Beta Induced Inflammatory Response via Inhibition of MAPK Signaling Pathways in Rat Articular Chondrocytes

Contact Info

Product

Resources

About