Effects of Coenzyme Q10 in Early Parkinson Disease

Shults, Clifford W.; Oakes, David; Kieburtz, Karl; Beal, M. Flint; Haas, Richard; Plumb, Sandy; Juncos, Jorge L.; Nutt, John G.; Shoulson, Ira; Carter, Julie; Kompoliti, Katie; Perlmutter, Joel S.; Reich, Stephen G.; Stern, Matthew B.; Watts, Ray L.; Kurlan, Roger; Molho, Eric; Harrison, Madaline B.; Lew, Mark F.

doi:10.1001/archneur.59.10.1541

Cited by 870 publications

(164 citation statements)

References 50 publications

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“…The risk of stroke is increasing gradually with increased plasma total homocysteine (tHCY) levels, independently of other cerebrovascular risk factors such as age, BMI, hypertension, smoking, diabetes, high-density lipoprotein cholesterol levels, creatinine, alcohol consumption and social class [1,2,3]. The significant correlation between tHCY and mortality from cardiovascular diseases is considered as an indication of the various frequencies of vascular pathologies across different populations and supports the hypothesis of tHCY as an independent cerebrovascular risk factor [4,5,6].…”

Section: Introductionmentioning

confidence: 99%

Associations between Serum Selenium and Total Plasma Homocysteine during the Acute Phase of Ischaemic Stroke

Angelova¹,

Atanassova

Chalakova

et al. 2008

Eur Neurol

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Background/Aims: Risk of ischaemic stroke (IS) was associated with total homocysteine (tHCY). On the other hand, serum selenium (Se) exhibited anti-aging and cardiopreventive effects. Se and tHCY showed relationships in animals but these were contradictory or inconclusive in humans; therefore, we searched for such associations in acute IS. Methods: Ninety-four participants aged around 47 years were identified and 39 patients versus 46 healthy controls were analysed. Clinical, laboratory (blinded) and risk factor questionnaire methods were used. Comparison, correlation and multifactorial regression analyses were applied. Results: IS patients were similar to controls concerning age and gender. IS was prevalent in the carotid system (76.9%); 82.1% had a subacute onset. IS patients expressed higher tHCY (14.65 ± 9.79 µmol/l) and lower Se levels (1.3 ± 0.5 µmol/l). Twice as many IS patients (23%) had optimal Se levels of <1.01 µmol/l. Subjects with hyperhomocysteinaemia (tHCY ≧15 µmol/l) showed lower Se levels during IS; Se accounted for 15.4% of tHCY variations (R = –0.393; p = 0.015) with unit change increasing tHCY by 8.25 units. Se remained predictive of tHCY levels after adjustments (vitamin B₆, fibrinogen, triglycerides). Conclusions: Lower Se was observed during acute IS, being inversely associated with and predicting increased tHCY levels. Of note, there were more IS patients with suboptimal Se than controls.

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Section: Introductionmentioning

confidence: 99%

Associations between Serum Selenium and Total Plasma Homocysteine during the Acute Phase of Ischaemic Stroke

Angelova¹,

Atanassova

Chalakova

et al. 2008

Eur Neurol

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“…Cholesterol levels are the main determinant of coenzyme Q10, an important antioxidant and mitochondrial electron receptor [25]. Coenzyme Q10 is neuroprotective and in study involving patients with early Parkinson disease, administration of high-dosage (1200 mg/day) coenzyme Q10 significantly slowed progression of disability with halting of their statin [26].…”

Section: Review Of the Statin Sagamentioning

confidence: 99%

The Ugly Side of Statins. Systemic Appraisal of the Contemporary Un-Known Unknowns

Sultan¹,

Hynes²

2013

OJEMD

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Cardio-vascular specialists have witnessed and actively participated in the revolutionary developments that have occurred in their field of specialization over the last few years. Cutting-edge technologies have led to dramatic improvements in life-expectancy and quality of life. An open-mind and pioneering attitude are necessary when exploring new frontiers to improve our patients' health. However, naïve indiscriminate acceptance of novel mainstream therapies is not always advisable and prudence is required in unearthing harmful, covert side effects. An objective review of contemporary vascular research was performed and industrial bias was sifted out for a fresh prospective on how to promote primary cardiovascular prevention with attainable lifestyle adjustments [1]. A comprehensive review of Pubmed, EM-BASE and Cochrane review databases was undertaken for articles relating to cardiovascular primary prevention and statin side effects with the aim of harmonising their roles within contemporary clinic practice. Particular attention was paid to large-scale randomised controlled trials on contemporary cardiovascular pharmacotherapies and their specific adverse effects on metabolic pathways which feature prominently in cardiovascular primary prevention and regenerative programmes. There is a categorical lack of clinical evidence to support the use of statin therapy in primary prevention. Not only is there a dearth of evidence for primary cardiovascular protection, there is ample evidence to show that statins actually augment cardiovascular risk in women, patients with Diabetes Mellitus and in the young. Furthermore statins are associated with triple the risk of coronary artery and aortic artery calcification. Cardiovascular primary prevention and regeneration programmes, through life style changes and abstaining from tobacco use have enhanced clinical efficacy and quality of life over any pharmaceutical or other conventional intervention.

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“…A small phase II trial (QE2) supported by the National Institute for Neurological Disorders and Stroke (NINDS) showed that 20 patients taking 1,200 milligrams per day of coenzyme Q10 for 12 months had a 44% slower degeneration rate than those on placebo 3 . Degeneration is assessed by change in the Unified Parkinson's Disease Rating Scale (UPDRS) -a set of scores derived from interviews and clinical observations that assess a patient's motor skills, behaviour and ability to perform daily tasks.…”

Section: Troublesome Trialsmentioning

confidence: 99%

Slowing the decline

Williams

2010

Nature

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Effects of Coenzyme Q10 in Early Parkinson Disease

Cited by 870 publications

References 50 publications

Associations between Serum Selenium and Total Plasma Homocysteine during the Acute Phase of Ischaemic Stroke

Associations between Serum Selenium and Total Plasma Homocysteine during the Acute Phase of Ischaemic Stroke

The Ugly Side of Statins. Systemic Appraisal of the Contemporary Un-Known Unknowns

Slowing the decline

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