Effects of coenzyme Q10 encapsulated in nanoliposomes on wound healing processes after tooth extraction

Abstract

Background/purpose Tooth extraction is often followed by a number of different complications that demand additional treatment. In order to accelerate healing processes and decrease the complication occurrence various agents, growth factors, natural and synthetic antioxidants (e.g coenzyme Q 10 -CoQ 10 ), are applied. Due to the partially known health-promoting effects of CoQ 10 we decided to assess potential of it's encapsulated in nanoliposomes form on wound healing process following tooth extraction. Materials and methods Effects of free and encapsulated form of CoQ 10 on wound healing processes after tooth extraction in rats, 3 and 7 days following surgical procedure, was studied by means of tissue biochemical (myeloperoxidase activity and nitric oxide (NO) concentrations) and pathohistological analysis. Results The obtained results indicate that the encapsulated form of CoQ 10 compared to control and CoQ 10 treated animals statistically significantly decreases inflammatory process estimated through myeloperoxidase activity and NO concentrations, as well as based on histopathological analysis 3 and 7 days following surgery. Conclusion The results of this study unequivocally prove that the encapsulation of CoQ 10 in nanoliposomes enhances CoQ 10 activity by accelerating wound healing process after tooth extraction.

Wound healing acceleration in inflammation phase of post-tooth extraction after aerobic and anaerobic exercise

“…PMN and macrophages in the inflammatory phase have the function of phagocytosis to digest and destroy bacteria, producing toxic content in the form of lactoferin, proteases, neutrophil elastase, and catepsin which can destroy bacteria, and increase free radicals (ROS) and when ROS production become excessive the wound healing process may be disrupted. Activated macrophage infiltration increases nitric oxide concentration (NO) which is a diatomic free radical produced by activated phagocytic leukocytes (neutrophils and macrophages) where both have dangerous properties and also beneficial in tissue pathophysiological process [4,17]. PMN also release FGF, TGF-␤, TGF-␣, and PDGF which will help fibroblasts proliferation and angiogenesis in the next phase of healing process.…”

Polymeric Biomaterials for Wound Healing Incorporating Plant Extracts and Extracellular Matrix Components

“…A reduction in inflammatory reaction and increase in collagen deposition following surgical procedure, were previously obtained in animals when CoQ10 was applied in a form of ointment resulting. The expression of IL-1β, TNF-α, NF-κB and HO-1, cytokines involved in inflammation and oxidative tissue damage, were significantly suppressed by CoQ10 application for 3 days following surgical procedure [25]. The ECM was shown to be more stimulated to facilitate wound healing when formulated with biomaterials.…”

“…This potential dressing for infected wounds was effective in preventing the proliferation of microorganism. Encapsulation of CoQ10 in nanoliposomes has also been shown to enhance CoQ10 activity by accelerating wound healing process after tooth extraction [24,25]. A reduction in inflammatory reaction and increase in collagen deposition following surgical procedure, were previously obtained in animals when CoQ10 was applied in a form of ointment resulting.…”

Lipid-Based Drug Delivery Systems in Regenerative Medicine

“…Reducing the friction between the cartilage surfaces around the joints can protect the cartilage from damage caused by rheumatoid arthritis. Todorovic et al [ 75 ] evaluated the effect of CoQ 10 encapsulation in nanoliposomes on wound healing after tooth extraction through tissue biochemical (myeloperoxidase activity and nitric oxide concentration) and histopathological analyses. The results showed that the encapsulation of CoQ 10 in nanoliposomes significantly reduced wound inflammation after tooth extraction in rats and enhanced the ability of CoQ 10 to promote wound healing.…”