Effects of cocaine-induced sensitization on ethanol drinking: sex and strain differences

Cailhol, Stéphanie; Mormède, Pierre

doi:10.1097/00008877-200008000-00004

Cited by 14 publications

(7 citation statements)

References 47 publications

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“…Indeed, amphetaminesensitized rats were found to consume significantly more ethanol than the saline-treated controls following a 3-month drug-free interval (Fahlke et al, 1994). However, in line with our studies, cocaine-induced sensitization did not modify either the acquisition or the maintenance of ethanol drinking in Wistar-derived hyperactive and hypertensive rat strains (Cailhol and Morme`de, 2000). It remains to be seen whether the discrepancies among the studies are related to differences in methodological issues or in the mechanisms mediating reinforcement from different drugs.…”

Section: Discussionsupporting

confidence: 88%

Enhanced Morphine‐Induced Ethanol Drinking in Alcohol‐Preferring Alko Alcohol Rats Sensitized to Morphine

Ojanen¹,

Hyytiä²,

Kiianmaa³

2006

Alcoholism Clin & Exp Res

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Ethanol did not interfere with the development of sensitization to morphine. Furthermore, the neuroadaptations induced by repeated exposure to ethanol were sufficient to cause behavioral cross-sensitization to morphine. Sensitization to the behavioral effects of morphine alone, however, neither enhances the reinforcing properties of voluntarily consumed ethanol nor contributes to increase in its intake. The increase in ethanol intake found after an acute dose of morphine was augmented in rats withdrawn from repeated treatment with morphine. The data suggest that the neuronal mechanisms underlying behavioral sensitization to morphine probably are distinct from those mediating reinforcement from ethanol and that the morphine-induced neuroadaptations contribute to the enhancement of increase in ethanol intake by morphine.

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Section: Discussionsupporting

confidence: 88%

Enhanced Morphine‐Induced Ethanol Drinking in Alcohol‐Preferring Alko Alcohol Rats Sensitized to Morphine

Ojanen¹,

Hyytiä²,

Kiianmaa³

2006

Alcoholism Clin & Exp Res

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“…Moreover, Cailhol and Mormède [44] reported that SHR rats showed higher levels of cocaine-induced behavioral sensitization when compared to WKHA, but not to WKY, rats. In a subsequent study, the authors reported similar levels of cocaine sensitization for these three strains [45]. On the other hand, repeated MPD treatment (2.5 mg/kg, IP) induced sensitization in SD, but with a weak effect and with no effect in WKY and SHR rats, respectively.…”

Section: Psychostimulantsmentioning

confidence: 71%

“…In adolescent rats, chronic treatment with MPD (0.6, 2.5 and 10 mg/kg, IP) failed to elicit sensitization in SD, WKY and SHR rats [39]. In studies comparing rats of both sexes, SHR females are more sensitive to both the acute effect of psychostimulants and the sensitization produced by these drugs than SHR males [44,45].…”

Section: Psychostimulantsmentioning

confidence: 94%

Drug Reinforcement in a Rat Model of Attention Deficit/Hyperactivity Disorder – The Spontaneously Hypertensive Rat (SHR)

Vendruscolo¹,

Izídio²,

Takahashi

2009

CDAR

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The co-occurrence of drug addiction in adults with attention deficit hyperactivity disorder (ADHD) is very common, but its etiology remains largely unknown. Therefore, animal models to study this kind of psychiatric comorbidity are needed. The Spontaneously Hypertensive Rat (SHR) strain shows neurochemical and behavioral characteristics which make it a suitable model of ADHD. Compared with their normotensive controls (Wistar-Kyoto) and with some other rat strains, SHR rats drink more ethanol and are more sensitive to its anxiolytic/stimulant effects. They also show increased sensitivity to psychostimulants, opioids and cannabinoids. Furthermore, chronic treatment with methylphenidate, the first-choice drug to treat ADHD, during adolescence, changes the ethanol intake and the behavioral effects of cocaine in adult SHR rats. Regarding sex differences, females are more sensitive to psychostimulants and drink more ethanol than males, an important condition because in adulthood, more females suffer from ADHD than males. Taken together, the reviewed findings indicate that the SHR strain is a promising tool for studies on drug addiction and, possibly, its relationship with ADHD.

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“…EtOH + cocaine solution enhanced responding for EtOH (Ikegami et al., ). Systemic administration of cocaine resulted in decreased (Uemura et al., ) or had no effect (Cailhol and Mormede, ) on EtOH intake. Collectively, these studies show that cocaine effects on EtOH intake are complex and may vary depending on the experimental protocol.…”

mentioning

confidence: 99%

Cocaine Influences Alcohol‐Seeking Behavior and Relapse Drinking in Alcohol‐Preferring (P) Rats

Hauser

Wilden

Deehan

et al. 2014

Alcoholism Clin & Exp Res

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Background The results of several studies suggest that there may be common neurocircuits regulating drug-seeking behaviors. Common biological pathways regulating drug-seeking would explain the phenomenon that seeking for one drug can be enhanced by exposure to another drug of abuse. The objective of the current study was to assess the time-course effects of acute cocaine administration on alcohol seeking and relapse. Methods Alcohol-Preferring (P) rats were allowed to self-administer 15% ethanol (EtOH) and water. EtOH-seeking was assessed through use of the Pavlovian Spontaneous Recovery (PSR) model, while relapse EtOH drinking was assessed through use of the alcohol deprivation effect. Results Cocaine (0, 1 or 10 mg/kg), injected immediately, 30 min, or 4 hr prior to the 1st PSR testing session, dose-dependently increased responding on the EtOH lever compared to extinction responses and responding by saline controls. Under relapse conditions, cocaine given immediately prior to the relapse session had no effect (1 mg/kg) or reduced responding (10 mg/kg). In contrast, cocaine given 4 hr prior to the relapse session markedly enhanced EtOH responding compared to saline. Conclusion The enhanced expression of EtOH-seeking and relapse behaviors may be a result of a priming effect of cocaine on neuronal circuits mediating these behaviors. The effect of cocaine on EtOH-relapse drinking is indicative of the complex interactions that can occur between drugs of abuse; production of conflicting behaviors (immediate) and priming of relapse/seeking (4 hour delay).

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Effects of cocaine-induced sensitization on ethanol drinking: sex and strain differences

Cited by 14 publications

References 47 publications

Enhanced Morphine‐Induced Ethanol Drinking in Alcohol‐Preferring Alko Alcohol Rats Sensitized to Morphine

Enhanced Morphine‐Induced Ethanol Drinking in Alcohol‐Preferring Alko Alcohol Rats Sensitized to Morphine

Drug Reinforcement in a Rat Model of Attention Deficit/Hyperactivity Disorder – The Spontaneously Hypertensive Rat (SHR)

Cocaine Influences Alcohol‐Seeking Behavior and Relapse Drinking in Alcohol‐Preferring (P) Rats

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