Effects of cocaine and alcohol use in pregnancy on neonatal growth and neurobehavioral status

Coles, Claire D.; Platzman, Kathleen A.; Smith, Iris; James, Mark E.; Falek, Arthur

doi:10.1016/0892-0362(92)90025-6

Cited by 239 publications

(129 citation statements)

References 27 publications

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“…Thus, neonatal medical condition might mediate some of the effects of cocaine exposure on arousal regulation and the capacity to calm following a perturbation . Women who use cocaine during pregnancy are also more likely to use alcohol, cigarettes, and marijuana than are women who do not use cocaine (Behnke, Eyler, Conlon, Woods, & Casanova, 1994;Coles et al, 1992;Eyler, Behnke, Conlon, Woods, & Frentzen, 1994). Prenatal exposure to alcohol, for example, has been associated with possible emotional regulation problems during infancy, including state lability, irritability, poor attention, and temper tantrums, as well as negative affect (O'Connor, Sigman, & Kasari, 1993;Streissguth, 1986).…”

mentioning

confidence: 99%

Arousal modulation in cocaine-exposed infants.

Bendersky¹,

Lewis²

1998

Developmental Psychology

109

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The ability to modulate arousal is a critical skill with wide-ranging implications for development. In this study, the authors examined arousal regulation as a function of levels of prenatal cocaine exposure in 107 infants at 4 months of age using a "still-face" procedure. Facial expressions were coded. A greater percentage of heavily cocaine-exposed infants, compared with those who were unexposed to cocaine, showed less enjoyment during en face play with their mothers and continued to show negative expressions during the resumption of play following a period when the interaction was interrupted. This finding was independent of other substance exposure, neonatal medical condition, environmental risk, maternal contingent responsivity, and concurrent maternal sensitivity and vocalizations.

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mentioning

confidence: 99%

Arousal modulation in cocaine-exposed infants.

Bendersky¹,

Lewis²

1998

Developmental Psychology

109

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“…Other investigators suggested that maternal and obstetric risk factors, lack of prenatal care, undernutrition, and effects of cocaine and nicotine on uterine blood flow might be involved in the mechanism of growth restriction. 22,[24][25][26][27][28][29] Recently, an interaction between metabolic genes and cigarette smoking was demonstrated. 12 In this study, infant birth weight, length, and head circumference were lower in the presence of multidrug use.…”

mentioning

confidence: 99%

Association Between Patterns of Maternal Substance Use and Infant Birth Weight, Length, and Head Circumference

et al. 2004

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ABSTRACT. Objective. To determine the effects of patterns of drug use during term pregnancy on infant growth parameters at birth.Methods. Histories of cocaine, opiate, alcohol, tobacco, and marijuana use during the 3-month period before pregnancy and the 3 trimesters of pregnancy were recorded at the infants' 1-month visit. Patterns of use were categorized as consistently high, moderate, or low/ none or increasing/decreasing, and effects on growth parameters were analyzed in multivariate linear regression analyses, with adjustment for clinical site, maternal age, prepregnancy weight, multidrug use, and socioeconomic status.Results. A total of 241 cocaine-exposed women and 410 non-cocaine-exposed women participated in the study. In the cocaine-exposed group, 75% used alcohol, 90% used tobacco, and 53% used marijuana; in the noncocaine-exposed group, 57% used alcohol, 34% used tobacco, and 19% used marijuana. Birth weight, birth length, and head circumference were significantly greater among infants born to women who used no drugs, compared with women with any cocaine, opiate, alcohol, tobacco, or marijuana use, and were greater among infants born to cocaine nonusers, compared with cocaine users. With adjustment for confounders, birth weight was significantly affected by cocaine (deficit of 250 g with consistently low pattern) and tobacco (deficits of 232 g with consistently high pattern, 173 g with consistently moderate pattern, 153 g with decreasing pattern, and 103 g with consistently low pattern). Head size was affected by cocaine (deficit of 0.98 cm with consistently moderate pattern) and tobacco (deficits of 0.72 cm with consistently high pattern and 0.89 cm with consistently moderate pattern). Birth length was affected by tobacco use only (deficits of 0.82 cm with consistently high pattern and 0.98 cm with decreasing use).Conclusion. Patterns of tobacco use during pregnancy affect birth weight, length, and head circumference, whereas cocaine affects birth weight and head size, when adjustments are made for confounders, including multidrug use. Pediatrics 2004;114:e226 -e234. URL: http: //www.pediatrics.org/cgi/content/full/114/2/e226; prenatal, cocaine, alcohol, tobacco, marijuana, infant birth weight, length, head circumference.ABBREVIATIONS. MISU, Maternal Inventory of Substance Use. M aternal cocaine use during pregnancy has been associated with decreased growth parameters at birth for infants. [1][2][3][4][5] Women who use cocaine during pregnancy are often exposed to many drugs, including alcohol and tobacco, 1-6 both of which have been shown to have effects on birth weight in studies evaluating the use of these substances alone or in combination. [7][8][9][10][11][12][13] The timing and amount of fetal exposure to cocaine, tobacco, and alcohol during pregnancy also have been noted to influence birth weight. 2,10,11,14 Infants born to women who stopped smoking had higher birth weights than did those born to women who reduced smoking or who did not change behavior. 10,11 Infants born to women who drank ...

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“…Disruption in placental/fetal vasculature has been reported (Church, 1993;Delaney-Black et al, 1996;Doberczak, Snanzer, Senie, & Kandall, 1988;Malanga & Kosofsky, 1999;Richardson & Day, 1991). Spontaneous abortion, decreased birth weight, birth length, and head circumference also have been associated with in-utero cocaine exposure (Chiriboga, Brust, Bateman, & Hauser, 1999;Coles, Platzman, Smith, James, & Falek, 1992). Abnormal EEGs, brainstem transmission times, cries and problems with autonomic stability have been reported in the neonate (Corwin, Lester, Sepkoski, McLaughlin, Kayne, & Golub, 1992;Doberczak et al, 1998;Scher, Richardson, & Day, 2000).…”

Section: Sleep Architecture 3 Sleep Architecture In Infants Of Substamentioning

confidence: 99%

“…Neurobehavioral processes such as habituation, attention, regulation of state, learning, language, play, and motor/tone also have been reported as negatively effected Sleep Architecture 4 by in-utero cocaine exposure. This includes decreases in social behavior and activity level (Chasnoff, 1993;Chiriboga, Brust, Bateman, & Hauser, 1999;Church, 1993;Coles et al, 1992;Corwin et al, 1992;Delaney-Black et al, 1996;Delaney-Black, Covington, Templin, Ager, Martier, & Sokol, 1998;Doberczak, 1998;Eisen et al, 1991;Malanga & Kosofsky, 1999;Mayes, Granger, Frank, Schottenfeld, & Bornstein, 1993;Richardson & Day, 1991;Schneider & Chasnoff, 1992;Stewart & Meeker, 1997;Tronick & Beeghly, 1999;Tronick, Frank, Cabral, Mirochnick, & Zuckerman, 1996;Volpe, 1992). Methamphetamine has been associated with dysmorphogenic effects such as clefting and cardiac anomalies, fetal death, reduced growth, and learning and behavioral problems (Stewart & Meeker, 1997).…”

Section: Sleep Architecture 3 Sleep Architecture In Infants Of Substamentioning

confidence: 99%

“…This is at least in part due to the fact that substance-abusing populations have been notoriously difficult to Sleep Architecture 5 study. Along with problems of compliance and variable amounts of substance abuse that are very difficult to quantify, there are often many additional confounding factors, such as social and economic circumstances that include poverty, stress, trauma, physical and psychological abuse, and the use of more than one substance (Chasnoff, 1993;Chiriboga et al, 1999;Church, 1993;Coles et al, 1992;Johnson & Leff, 1999).…”

Section: Sleep Architecture 3 Sleep Architecture In Infants Of Substamentioning

confidence: 99%

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Sleep Architecture in Infants of Substance-Abusing Mothers

Hanft

Burnham

Goodlin‐Jones

et al. 2006

Infant Ment. Health J.

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Sleep Architecture in Infants of Substance Abusing MothersThis longitudinal, year-long study compared sleep-wake state organization in two groups of infants: infants whose mothers abused substances during their pregnancies, and non-exposed, typically developing, age-matched comparison infants, to determine whether differences in sleep-wake state organization existed between the two groups. Seventeen infants of mothers who were participating in a parent-infant residential treatment program for substance abuse were enrolled. Their sleep-wake state organization over the first year of life was compared to that of 17 age-matched comparison infants. The intent was to follow each infant on 5 occasions over the first year of life using established methods of time-lapse videosomnography to record sleep-wake state organization. However, attrition in the substance-abusing group was problematic. Some sleep-wake variables (Active Sleep%, Quiet Sleep%, Awake%, number of nighttime

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Effects of cocaine and alcohol use in pregnancy on neonatal growth and neurobehavioral status

Cited by 239 publications

References 27 publications

Arousal modulation in cocaine-exposed infants.

Arousal modulation in cocaine-exposed infants.

Association Between Patterns of Maternal Substance Use and Infant Birth Weight, Length, and Head Circumference

Sleep Architecture in Infants of Substance-Abusing Mothers

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