Effects of cocaine administration on receptor binding and subunits mRNA of GABAA-benzodiazepine receptor complexes

Suzuki, Tomohiko; Abe, Shuzo; Yamaguchi, M.; Baba, Atsuomi; Hori, Takafumi; Shiraishi, Hiroyasu; Ito, Takehiko

doi:10.1002/1098-2396(200011)38:2<198::aid-syn11>3.0.co;2-k

Cited by 31 publications

(27 citation statements)

References 107 publications

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“…Similarly, withdrawal from a high dose of cocaine was associated with decreased D 1 receptor binding in the striatum (Macedo et al, 2004), while dopamine D 2 receptor binding was upregulated. As the dopamine D 1 receptor is positively coupled to cAMP production, whereas the D 2 receptor is negatively coupled, the observed decrease in D 1 receptors (and increase in D 2 ) may represent a functional adaptation to decrease cAMP production in the ventral striatum, consistent with reduced dopamine stimulation of cAMP in the striatum of recently Baumann and Rothman (1996) g Darmani et al (1997) h King et al (1999) i Weiss et al (1992) j Persico et al (1993) k Paulson and Robinson (1996) (2000) w Schmidt et al (2001) x Zhang et al (1996) y Lu et al (1997) z Crespo et al (2002) aa Loftis and Janowsky (2000) ab Lu et al (2003) ac Loftis and Janowsky (2000) ad Crespo et al (2002) ae Loftis and Janowsky (2002) af Dworkin et al (1995) ag Lynch and Leonard (1978b) ah Suzuki et al (2000) ai Mohila and Onn (2005) aj Loftis and Janowsky (2000) ak al Persico et al (1998) am Mutschler et al (2000) abstinent human methamphetamine abusers (Tong et al, 2003). Levels of PKA were higher in the nucleus accumbens after withdrawal from cocaine self-administration .…”

Section: Psychostimulant Withdrawal In Animals-physiological Effectsmentioning

confidence: 76%

“…Levels of GABA and its turnover rate were altered in diffuse brain regions during withdrawal from amphetamine and cocaine (Lynch and Leonard, 1978b;Dworkin et al, 1995). Molecular studies observed that cocaine withdrawal was associated with decreased mRNA of the beta 3 subunit of the GABA A receptor in the cortex and caudate putamen (Suzuki et al, 2000), while a recent study noted that numbers of GABAergic interneurons immunoreactive for the calcium binding protein parvalbumin (PV) were increased in the anterior cingulate cortex during amphetamine withdrawal (Mohila and Onn, 2004). This latter finding is of interest, given recent studies showing that selective loss of PV-positive interneurons occurs in frontal cortex in schizophrenia (Hashimoto et al, 2003;Beasley and Reynolds, 1997) and may be associated with cognitive deficits that resemble those seen in some depressives.…”

Section: Psychostimulant Withdrawal In Animals-physiological Effectsmentioning

confidence: 99%

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Psychostimulant withdrawal as an inducing condition in animal models of depression

Barr

Markou

2005

Neuroscience & Biobehavioral Reviews

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Section: Psychostimulant Withdrawal In Animals-physiological Effectsmentioning

confidence: 76%

Section: Psychostimulant Withdrawal In Animals-physiological Effectsmentioning

confidence: 99%

Psychostimulant withdrawal as an inducing condition in animal models of depression

Barr

Markou

2005

Neuroscience & Biobehavioral Reviews

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“…Preclinical and clinical research has uncovered neurobiological perturbations in central GABA A receptors following chronic stimulant administration. Specifically, repeated administration of cocaine or methamphetamine to rodents results in region-specific changes in the mRNA and protein of certain benzodiazepine receptor subunits (Lilly and Tietz, 2000; Suzuki et al, 2000), as well as the number of benzodiazepine-GABA A receptor binding sites (Goeders, 1991; Yoo et al, 2010) and GABA A receptor function (Peris, 1996). These neurobiological changes were associated with differences in the acute behavioral response to these stimulant drugs (Goeders, 1991; Peris, 1996; Suzuki et al, 2000; Yoo et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Physiological and subjective effects of acute intranasal methamphetamine during extended-release alprazolam maintenance

Lile

Stoops

Glaser

et al. 2011

Drug and Alcohol Dependence

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Background Medications development for methamphetamine dependence is ongoing, but no widely accepted, effective pharmacotherapy has been identified. Previous studies have demonstrated neurobiological perturbations to central GABAA activity following chronic stimulant use, and that positive modulation of GABAA receptors attenuates the neurochemical and behavioral response to stimulant drugs such as methamphetamine. Therefore, GABAA modulators could be useful as pharmacotherapies for stimulant-use disorders. Methods This study tested the hypothesis that intranasal methamphetamine would be safe and well tolerated during maintenance on extended-release alprazolam (XR), and that the effects of methamphetamine would be attenuated. Eight non-treatment-seeking, stimulant-dependent individuals completed an inpatient experiment in which ascending doses of intranasal methamphetamine (0, 5, 10, 20 and 30 mg) were administered after four days of alprazolam XR maintenance (0 and 1 mg/day). Results Intranasal methamphetamine produced prototypical effects (e.g., increased positive subjective ratings and elevated cardiovascular signs). The combination of intranasal methamphetamine and alprazolam XR was safe and well tolerated. Alprazolam XR produced small, but orderly, reductions in some of the subjective effects of methamphetamine, and performance impairment. Conclusions The present results demonstrate that methamphetamine use during alprazolam XR treatment would not pose a significant safety risk. Given the potential of GABAA positive modulators to manage certain aspects of stimulant abuse and dependence (i.e., drug-induced seizures, anxiety and stress), but the relatively small impact on the acute abuse-related effects of methamphetamine observed here, additional research with GABAA positive modulators is warranted, but should consider their use as an adjunct component of combination behavioral and/or drug treatment.

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“…They include neurotransmission systems for dopamine (Sorg and Kalivas, 1993;Chausmer et al, 2002), glutamate (Brackett et al, 2000), serotonin (Muller et al, 2002), and GABA (Suzuki et al, 2000). Calcium channels play an important role in the locomotor-stimulating effects of cocaine (Han et al, 2002), and sodium and potassium channels mediate some toxic effects of the drug (Bauman and DiDomenico, 2002).…”

mentioning

confidence: 99%

Cocaine Up-Regulates Fra-2 and σ-1 Receptor Gene and Protein Expression in Brain Regions Involved in Addiction and Reward

Liu¹,

Chen²,

Lerner³

et al. 2005

J Pharmacol Exp Ther

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Receptors have recently been implicated in the actions of cocaine, and antagonists of these receptors prevent many acute and subchronic cocaine effects. A previous study revealed that the immediate early gene fra-2 is up-regulated after cocaine administration, and this effect is prevented by the -1In the present study, the effects of cocaine and BD1063 on the expression of six fos and jun genes were evaluated in mouse brains using cDNA microarrays. Several of these genes were altered by cocaine, but only the alteration in fra-2 was prevented by BD1063. The time courses of fra-2 and -1 receptor gene and protein expression in different brain regions were also determined. Cocaine up-regulated fra-2, which was followed by a later up-regulation of -1 receptors. The cocaine-induced up-regulation of fra-2 and -1 receptor genes and proteins were detected in whole brain, striatum, and cortex, but not in cerebellum. All of these cocaine-induced effects were prevented by BD1063. The interaction between cocaine, fra-2, and -1 receptors involves brain regions that are established components of the neural circuit for reward, suggesting that they may contribute to the enduring changes that underlie the cellular basis of drug abuse.

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Effects of cocaine administration on receptor binding and subunits mRNA of GABAA-benzodiazepine receptor complexes

Cited by 31 publications

References 107 publications

Psychostimulant withdrawal as an inducing condition in animal models of depression

Psychostimulant withdrawal as an inducing condition in animal models of depression

Physiological and subjective effects of acute intranasal methamphetamine during extended-release alprazolam maintenance

Cocaine Up-Regulates Fra-2 and σ-1 Receptor Gene and Protein Expression in Brain Regions Involved in Addiction and Reward

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