Effects of coagulation factor XIII (Val34Leu) polymorphism on recurrent pregnancy loss in Iranian Azeri women

Isazadeh, Alireza; Azimian, Saba Haj; Tariverdi, Nazila; Rahmani, Seyed Ali; Esmaeili, Maryam; Karimkhanilouei, Samaneh; Mohammadoo‐Khorasani, Milad

doi:10.1515/labmed-2017-0012

Cited by 15 publications

(9 citation statements)

References 24 publications

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“…According to results of this study which was performed on 50 AZS patients and 50 healthy controls, there was a significant association between NOS3 gene rs1799983 G/T polymorphism and AZS in Iranian infertile male. The reasons for the difference of reported results among the above studies could be due to several other related genes and environmental factors, and difference in studied samples size, ethnicity, race, and geographical area [27][28][29].…”

Section: Discussionmentioning

confidence: 84%

Association ofnitric oxidesynthase3gene rs1799983 G/T polymorphism with idiopathic asthenozoospermia in Iranian Azeri males: a case-control study

Chavoshi

Kaleybar

2020

Hormone Molecular Biology and Clinical Investigation

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AbstractObjectivesRecently, oxidative stress (OS) has been described extensively as an important cause of men infertility. The nitric oxide synthase 3 (NOS3) gene expression involved in normal spermatogenesis regulation in testis. Several single nucleotide polymorphisms (SNPs) on NOS3 gene are reported in association with sperm function and spermatogenesis impairment in infertile men. In present study, we investigated association of NOS3 gene rs1799983 G/T polymorphism in Iranian Azeri male with idiopathic asthenozoospermia (AZS).MethodsIn this case-control study, we collected 50 males with idiopathic AZS as a case group and 50 age and ethnically matched male as healthy controls from East Azerbaijan area, Iran. The case and control groups genotyping was performed using tetra-primer amplification refractory mutation system-polymerase chain reaction (Tetra-ARMS PCR) method.ResultsGenotype frequency in AZS patients was 40% GG, 60% GT, and 0% TT, whereas in healthy controls were 60% GG, 30% GT, and 10% TT. Statistical analysis showed that the GT heterozygous genotype frequency of NOS3 gene rs1799983 G/T polymorphism in AZS patients was significantly more than healthy controls (p>0.05).ConclusionsWe demonstrated that NOS3 gene rs1799983 G/T polymorphism was associated with AZS in Iranian Azeri men. However, more studies on different geographic areas, races and ethnicities are required to determine exact role of NOS3 gene rs1799983 G/T polymorphism in idiopathic AZS.

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Section: Discussionmentioning

confidence: 84%

Association ofnitric oxidesynthase3gene rs1799983 G/T polymorphism with idiopathic asthenozoospermia in Iranian Azeri males: a case-control study

Chavoshi

Kaleybar

2020

Hormone Molecular Biology and Clinical Investigation

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“…The discrepancies in the results of previous studies may be due to the interaction of other genes involved in male infertility. Moreover, differences in genetic background, geographical area, sample selection bias, sample size, environmental factors, ethnicity, and race are the possible could account for the contradiction in previous findings (20)(21)(22).…”

Section: Discussionmentioning

confidence: 84%

AURKC Gene Polymorphism (rs58264281) Associated with Idiopathic Male Infertility Risk in Northeast of Iran: A Case-Control Study

et al. 2021

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Background: Infertility is a major public health and social problem in human reproduction that is known as a multifactorial complex disorder. Genetic background and mutations and single nucleotide polymorphisms (SNPs) on the genes involved in sperm development are the important causes of male infertility. Objectives: In this study, we evaluated the association of AURKC gene polymorphism (rs58264281) and idiopathic male infertility in the Iranian Azeri population. Methods: This study was performed among 100 men with idiopathic infertility (case group) and 100 healthy men with successful fertility (control group) from East Azerbaijan, Iran. Genomic DNA extraction was carried out from peripheral blood samples by the proteinase K method. Genotype analysis was conducted by the tetra-primer amplification refractory mutation system-polymerase chain reaction (Tetra-ARMS PCR). SPSS version 21 was used for the analysis of the obtained data. Results: We observed that the CA and AA genotypes were significantly increased in patients with infertility as compared to healthy controls. Our results demonstrated that the mutant allele of AURKC gene polymorphism (rs58264281) was a significant risk factor in male infertility. Conclusions: We suggested a significant correlation between the AURKC gene rs58264281 polymorphism and male infertility in the Iranian Azeri population. However, further studies are required among other ethnicities, races, and geographic areas with larger sample sizes.

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“…Also, in some studies sublingual varices and fissured tongue have been considered as oral lesions, while these cases are oral anatomical norms and have not been evaluated in our study. The cultural differences, oral habits, educational level, and even genetic differences can be the cause of these differences [13].…”

Section: Discussionmentioning

confidence: 99%

Prevalence of oral mucosal status in resident and non-resident nursing home in Isfahan city, Iran: a comparative cross-sectional study

Saberi

Pakravan

Mohsenzadeh

2019

BDS

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Objective: The aim of this study was to evaluate the oral mucosal status of residents nursing home and non-resident in Isfahan, Iran and compare them with each other. Material and Methods: This was a cross-sectional study comparing 281 elderly in two groups: 141 resident and 140 non-residents nursing homes in Isfahan, Iran. The selection of nursing home and all of elderly was randomly. The nonresidents elderly were randomly selected from the public places adjacent to the nursing home. Persons were examining and the relevant information recorded in a checklists. Data were analyzed by SPSS version 24 using t-test, chi square, Mann- Whitney, Fisher exact test. (α=0/05). Results: The sample of the case was 281 people, including 135 males (48%) and 146 females (52%). Of all the subjects 153 patients (54.4%) had at least one oral lesion, 78 (55.3%) in resident nursing home and 75 (53.6%) in non-resident. There was no significant difference between two groups based on Chi-Square test (P>0/05). In this study, 25 different types of lesions were recorded, the most common lesion in all participants was epulis fissuratum (12.1%). Conclusion: The results showed that the prevalence of mucosal lesions is high in the elderly living in the centers and in the non-resident. Therefore, maintaining dentures is necessary to prevent and control lesions. KeywordsLesion; Mouth mucosa; Elderly; Nursing home; Cross-sectional study.

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Effects of coagulation factor XIII (Val34Leu) polymorphism on recurrent pregnancy loss in Iranian Azeri women

Cited by 15 publications

References 24 publications

Association ofnitric oxidesynthase3gene rs1799983 G/T polymorphism with idiopathic asthenozoospermia in Iranian Azeri males: a case-control study

Association ofnitric oxidesynthase3gene rs1799983 G/T polymorphism with idiopathic asthenozoospermia in Iranian Azeri males: a case-control study

AURKC Gene Polymorphism (rs58264281) Associated with Idiopathic Male Infertility Risk in Northeast of Iran: A Case-Control Study

Prevalence of oral mucosal status in resident and non-resident nursing home in Isfahan city, Iran: a comparative cross-sectional study

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