Effects of co-treatment of Plasmodium berghei-infected mice with aqueous extract of Ocimum gratissimum leaves and primaquine on glucose-6-phosphate dehydrogenase activity, hematological, and antioxidant parameters

C, Shedrach Kanu; Aloke, Chinyere; Elom, Nwabueze; O, Chinedum Eleazu

doi:10.1016/j.jaim.2022.100656

Cited by 1 publication

(1 citation statement)

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“…It is native to the Indian subcontinent and has extensively been utilized in Ayurveda and is frequently referred to as an "Elixir of Life" 21 . The medicinal properties of tulsi led to its use in treating epilepsy 22 , 23 , asthma 24 , cough 25 , anemia 26 , parasite infections 27 , 28 , neuralgia 29 , and inflammation 30 . Tulsi leaf extracts are recommended in the Indian Materia Medica for the treatment of pyrexia, rheumatism, and bronchitis 31 while the tea infusion has been used to treat hepatic and gastrointestinal diseases, the leaf juice has been utilized topically to cure earaches, malaria, snakebites, and mosquito bites 32 .…”

Section: Introductionmentioning

confidence: 99%

Green synthesis of silver nanoparticle prepared with Ocimum species and assessment of anticancer potential

Alex,

Subburaman,

Chauhan

et al. 2024

Sci Rep

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Silver nanoparticles (AgNPs) have gained much attention due to their unique physical, and chemical properties. Integration of phytochemicals in nanoformulation might have higher applicability in healthcare. Current work demonstrates the synthesis of green AgNPs with O. gratissimum (gr-AgNPs) O. tenuiflorum (te-AgNPs) and O. americanum (am-AgNPs) followed by an evaluation of their antimicrobial and anticancer properties. SEM analysis revealed spherical-shaped particles with average particle sizes of 69.0 ± 5 nm for te-AgNPs, 46.9 ± 9 nm for gr-AgNPs, and 58.5 ± 18.7 nm for am-AgNPs with a polydispersity index below 0.4. The synthesized am-AgNPs effectively inhibited Klebsiella pneumonia, Escherichia coli, Staphylococcus aureus, Aspergillus niger, and Candida albicans with 23 ± 1.58 mm, 20 ± 1.68 mm, 22 ± 1.80 mm, 26 ± 1.85 mm, and 22 ± 1.40 nm of zone of inhibition respectively. Synthesized AgNPs also induced apoptotic cell death in MCF-7 in concentration-dependent manner. IC50 values for am-AgNPs, te-AgNPs, and gr-AgNPs were 14.78 ± 0.89 µg, 18.04 ± 0.63 and 15.41 ± 0.37 µg respectively which suggested that am-AgNPs were the most effective against cancer. At higher dose size (20 µg) AgNPs were equally effective to commercial standard Doxorubicin (DOX). In comparison to te-AgNPs and gr-AgNPs, am-AgNPs have higher in vitro anticancer and antimicrobial effects. The work reported Ocimum americanum for its anticancer properties with chemical profile (GCMS) and compared it with earlier reported species. The activity against microbial pathogens and selected cancer cells clearly depicted that these species have distinct variations in activity. The results have also emphasized on higher potential of biogenic silver nanoparticles in healthcare but before formulation of commercial products, detailed analysis is required with human and animal models.

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