Effects of Clotrimazole on Experimental Spinal Cord Injury

Usul, Haydar; Çakır, Ertuğrul; Arslan, Erhan; Peksoylu, Bekircan; Alver, Ahmet; Sayin, Özgür; Topbaş, Murat; Baykal, Süleyman

doi:10.1016/j.arcmed.2005.11.007

Cited by 13 publications

(5 citation statements)

References 37 publications

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“…Recent evidence also suggests that TRPM2 may play a role in spinal cord injury and neuropathic pain. In a rat model of spinal cord injury, intraperitoneal (IP) injection of clotrimazole conjugated to polyethylene glycol significantly reduced lipid peroxidation, an indicator of oxidative stress, when administered 5 min after spinal cord compression 102 . Whether inhibition or knockdown of TRPM2 results in higher functional performance compared to untreated controls in a spinal cord injury model is unclear.…”

Section: Contribution Of Trpm2 To Cns Pathologymentioning

confidence: 99%

TRPM2: a candidate therapeutic target for treating neurological diseases

Belrose

Jackson

2018

Acta Pharmacol Sin

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Transient receptor potential melastatin 2 (TRPM2) is a calcium (Ca2+)-permeable non-selective cation channel belonging to the TRP ion channel family. Oxidative stress-induced TRPM2 activation provokes aberrant intracellular Ca2+ accumulation and cell death in a variety of cell types, including neurons. Aberrant TRPM2 function has been implicated in several neurological disorders including ischemia/stroke, Alzheimer's disease, neuropathic pain, Parkinson's disease and bipolar disorder. In addition to research identifying a role for TRPM2 in disease, progress has been made in the identification of physiological functions of TRPM2 in the brain, including recent evidence that TRPM2 is necessary for the induction of N-methyl-D-aspartate (NMDA) receptor-dependent long-term depression, an important form of synaptic plasticity at glutamate synapses. Here, we summarize recent evidence on the role of TRPM2 in the central nervous system (CNS) in health and disease and discuss the potential therapeutic implications of targeting TRPM2. Collectively, these studies suggest that TRPM2 represents a prospective novel therapeutic target for neurological disorders.

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Section: Contribution Of Trpm2 To Cns Pathologymentioning

confidence: 99%

TRPM2: a candidate therapeutic target for treating neurological diseases

Belrose

Jackson

2018

Acta Pharmacol Sin

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“…Clotrimazole, as an antifungal drug (Yoshida and Aoyama, 1987;Vanden Bossche et al, 1989), possesses diverse actions on cellular functions (Brugnara et al, 1993;Rettenhouse et al, 1997;Welker and Drews, 1997;Snajdrova et al, 1998;Wu et al, 1999;Ito et al, 2002;Isaev et al, 2002;Bartolommei et al, 2006;Usul et al, 2006). Clotrimazole also protects the cells treated with A23187, a calcium ionophore, inducing an overload of intracellular Ca 2+ resulting in the cell death in a Ca 2+ -dependent manner (Horimoto et al, 2006, also Fig.…”

Section: Discussionmentioning

confidence: 95%

“…It is proposed that clotrimazole is used as a neuroprotective agent (Isaev et al, 2002;Usul et al, 2006). However, this proposal may be unlikely because iron, one of products of hemoglobin degradation, plays a key role in brain injury under an intracerebral hemorrhage condition (Shao et al, 2005;Wan et al, 2006).…”

Section: Discussionmentioning

confidence: 98%

“…Furthermore, this agent certain conditions. Recent studies show that clotrimazole exerts neuroprotective effects via suppressing lipid peroxidation and blocking N-methyl-d-aspartate receptorgated channels (Isaev et al, 2002;Usul et al, 2006). In our previous study, clotrimazole also protects the cells treated with A23187, a calcium ionophore .…”

Section: Introductionmentioning

confidence: 89%

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Clotrimazole, an antifungal drug possessing diverse actions, increases the vulnerability to cadmium in lymphocytes dissociated from rat thymus

Oyama

et al. 2006

Toxicology

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“…This energy difference across the membrane affects the Na+/Ca++ flow across the membrane. The increased calcium leads to irreversible axonal degeneration [7][8][9]. Additionally, increased Na+ in the intracellular compartment has edematous effects for the cell.…”

Section: Discussionmentioning

confidence: 99%

Effects of Rifampicin on Experimental Spinal Cord Ischemia/Reperfusion Injury in Rats

Eminağaoğlu¹

2013

J Spine

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Objective: The effect of rifampisin was examined using a spinal cord ischemia/reperfusion (I/R) injury model in rats.Materials and Methods: 25 Wistar Albino rats weighing 200-250 g were used for the study. Rats were divided in 5 groups. After laparatomy, aorta was clamped 45 minutes below the left renal artery in all groups except shamoperated group. 1 cc saline was injected to vehicle group and rifampicin (20 mg/kg) was administered to treatment group intraperitoneally. In group 5, 20 mg/kg of rifampicin applied intraperitoneally before laparotomy. 2 hours after application of rifampicin, the animals underwent clip compression for 45 minutes after exposure of the abdominal aorta. At 1 h and 24 h, all groups were examined for neurologic outcome according to Tarlov scale. At 24 h, rats were sacrificed. The spinal cord was excised by laminectomy between the T8-12 levels and tissue MDA levels were studied. Results:At 1 h, difference between motor scores of sham-operated group and other groups was statistically significant (P=0.008). At 24 h, difference between trauma and treatment or p-treatment group was statistically significant (P<0.05). When MDA levels of the groups were compared by using Kruskal Wallis variance analysis, the result was statistically significant (P=0.001). When trauma and vehicle group were compared with treatment group by Mann Whitney U test, the results were statistically significant (P=0.008). Conclusions:To our knowledge, this is the first study that shows the effects of rifampicin on spinal cord ischemia/reperfusion injury. Rifampicin was found to be effective on spinal cord ischemia/reperfusion injury, but further investigations are mandatory.

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Effects of Clotrimazole on Experimental Spinal Cord Injury

Cited by 13 publications

References 37 publications

TRPM2: a candidate therapeutic target for treating neurological diseases

TRPM2: a candidate therapeutic target for treating neurological diseases

Clotrimazole, an antifungal drug possessing diverse actions, increases the vulnerability to cadmium in lymphocytes dissociated from rat thymus

Effects of Rifampicin on Experimental Spinal Cord Ischemia/Reperfusion Injury in Rats

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