Effects of clinoptilolite treatment on oxidative stress after partial hepatectomy in rats

Sarıbeyoğlu, Kaya; Aytaç, Erman; Pekmezci, Salih; Saygılı, Seha; Uzun, Hafize; Özbay, Gülşen; Aydın, Seval; Seymen, Hakki Oktay

doi:10.1016/j.asjsur.2011.11.007

Cited by 26 publications

(20 citation statements)

References 32 publications

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“…Zeolite's anti-oxidant properties have been well described before [16,40]. In a previous study, it was presented that zeolite administration reduces oxidative stress and supports antioxidant response after partial hepatectomy [41]. In our present study, zeolite could be able to decrease the levels of inflammatory cytokines due to its anti-oxidant properties.…”

Section: Discussionsupporting

confidence: 52%

Counteraction of Apoptotic and Inflammatory Effects of Adriamycin in the Liver Cell Culture by Clinopitolite

Yapışlar

Taşkın

Ozdas

et al. 2015

Biol Trace Elem Res

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Growing evidence has been reported on adriamycin (ADR) hepatotoxicity in literature. Hepatotoxicity caused by the use of drugs has a serious undesirable effect in the cure of cancer patients that needs to be eliminated. The exact mechanism of ADR on non-cancerous tissue still remains to be a mystery. The zeolite (clinoptilolite) minerals form a complex group of aluminosilicates that often occur as accessory minerals in intermediate and basic rocks. In light of this information, we investigated the possible anti-inflammatory and anti-apoptotic effects of clinoptilolite in ADR that is inducing the toxicity in primary liver cell culture. Primary liver cell culture from rat was used in the study. We had three experiment groups including the following: (1) cells treated only with 50 μM ADR for 24 h, (2) cells treated with the 50 μM ADR for 24 h and then treated with 10(-4) M zeolite for 1 h, and (3) cells were incubated with 50 μM ADR for 24 h and then incubated with 10(-4) M zeolite for 24 h to test its long-term effects. After that, western blotting was performed in order to evaluate protein expression levels of several inflammation markers including IL-1β, tumor necrosis factor (TNF)-α, and nuclear factor kappa B (NF-κB), and immunohistochemistry was carried out to detect apoptosis in liver cell culture. Also, TdT-dUTP Terminal Nick-End Labeling (TUNEL) method was used for detecting apoptosis. We found elevated levels of inflammatory protein and apoptotic markers in ADR-administered cells (p < 0.05). Inflammatory and apoptotic markers decreased significantly after treated with zeolite (p < 0.05). The present study was pointed out that ADR causes hepatotoxicity via apoptosis and/or inflammation processes resulting from initiator NF-κB and TNF which causes proinflammatory mediators such as IL-1β. Elevation of inflammation might give rise to trigger apoptosis. Clinoptilolite counteracted the apoptosis and inflammation induced by ADR arising from the decrease in NF-κB, TNF-α, and IL-1β protein levels.

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Section: Discussionsupporting

confidence: 52%

Counteraction of Apoptotic and Inflammatory Effects of Adriamycin in the Liver Cell Culture by Clinopitolite

Yapışlar

Taşkın

Ozdas

et al. 2015

Biol Trace Elem Res

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“…This finding was agreement with the study of Wu et al (2013b), who concluded that MDA concentration of the liver was decreased and the liver CAT activity was higher when supplemented with 2% clinoptilolite in poultry diets. Meanwhile, Wang et al (2012) reported supplementation with zinc-bearing clinoptilolite significantly reduced MDA contents of jejunal mucosa at 21 d. Saribeyoglu et al (2011) also found that Adding clinoptilolite up to 5 mg/kg in the diets could significantly decreased plasma and liver tissue MDA levels. These results suggested that the adding of zeolite may support antioxidant system.…”

Section: Discussionmentioning

confidence: 94%

“…The study of Wu et al (2013c) showed that zeolite increased the intestinal length and weigh and gut digestive enzyme activity, improved the intestinal morphology. In addition, Saribeyoglu et al (2011) found that clinoptilolite administration could decrease oxidant activity and increase antioxidant ability after partial hepatectomy.…”

Section: Introductionmentioning

confidence: 99%

Effects of Dietary Supplementation with the Combination of Zeolite and Attapulgite on Growth Performance, Nutrient Digestibility, Secretion of Digestive Enzymes and Intestinal Health in Broiler Chickens

Zhou¹,

Tan²,

Zhang³

et al. 2014

Asian Australas. J. Anim. Sci

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This study was designed to investigate the effects of basal diets supplemented with a clay product consisting of zeolite and attapulgite (ZA) at 1:1 ratio on growth performance, digestibility of feed nutrients, activities of digestive enzymes in small intestine and intestinal health in broiler chickens. In experiment 1, 112 one-day-old male chickens were randomly divided into 2 groups with 8 replicates of 7 chickens each. In experiment 2, 84 one-day-old male chickens were randomly allocated into 2 groups consisting 6 replicates of 7 chickens each. The experimental diets both consisted of a maize-soybean basal control diet supplemented with 0% or 2% ZA. The diets were fed from 1 to 42 days of age. The results showed that ZA supplementation could increase body weight gain (BWG) and feed intake (FI), but had no significant effect on feed conversion ratio. The apparent digestibility values of crude protein and gross energy were significantly increased (p<0.05) by ZA from 14 to 16 d and 35 to 37 d. Dietary ZA treatment significantly increased (p<0.05) the activities of amylase, lipase and trypsin in jejunal digesta and the activities of maltase and sucrase in jejunal mucosa on days 21 and 42. The ZA supplementation also significantly increased (p<0.05) the catalase activity, reduced (p<0.05) the malondialdehyde concentration in the jejunal mucosa. In addition, a decrease of serum diamine oxidase activity and an increase (p<0.05) in concentration of secretory immunoglobulin A in jejunal mucosa were observed in birds treated with ZA on 21 and 42 days. It is concluded that ZA supplementation (2%) could partially improve the growth performance by increasing BWG and FI. This improvement was achieved through increasing the secretion of digestive enzymes, enhancing the digestibilites of nutrients, promoting intestinal health of broiler chickens.

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“…It has been reported by some researchers that several factors improving and promoting the liver regeneration and some of them are as follows; prostaglandin E2 enhances the proliferation of hepatocytes by increasing intracellular cyclic AMP [30], nitric oxide, a flow-dependent factor is a trigger to initiate the regeneration process [31], antioxidant treatment with vitamin E [32], carvacrol [33], prostaglandin E1 [34], resveratrol and melatonin [35], Triiodothyronine (T3) [36], beneficial effects of clinoptilolite [37] and SDOA [4].…”

Section: Discussionmentioning

confidence: 99%

Comparing the regenerative effects of silymarin and apricot on liver regeneration after partial hepatectomy in rats

Yılmaz¹,

Hatipoğlu²,

Taşlıdere³

et al. 2018

biomedicalresearch

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This study is aimed to investigate and compare the regenerative effects of Silymarin (SLM); and Sun Dried Organic Apricot (SDOA) on liver regeneration after 70% Partial Hepatectomy (PH) in rats. Rats mean weighing was 238.1 ± 17.8 g, and they were randomly divided into the five groups. During the 17 d of the study period, the following feed and drug administration order was maintained: group 1 (sham) (n=6) and group 2 (n=8) were fed with standard rat chow, group 3 (n=8) was fed with standard rat chow and given additionally daily 100 mg/kg dose of silymarin extract by gavage, group 4 (n=8) was fed with 10% supplemented SDOA to chow and, in addition, they were given daily 100 mg/kg dose silymarin extract by gavage, and group 5 (n=8) was fed with 10% supplemented SDOA to chow. Water was given ad-libitum to all groups. After a week, group 1 had a laparoscopic procedure; the others underwent a 70% PH. On 18 th d of the study, all rats were humanely sacrificed. Taken liver tissue samples of all groups were used to histopathological and tissue biochemical examination. Approximately 10 ml blood samples were taken and the obtained serum samples were used for measurement of serum Aspartate Transaminase (AST) AST, Alanine Transaminase (ALT) and Alkaline Phosphatase (ALP) levels. The results of the present study revealed a remarkable protective effect of silymarin rather than SDOA based on the histopathological and Proliferating Cell Nuclear Antigen, (PCNA). PCNA findings and liver tissue/serum biochemical parameters. Therefore, before 7 and after 10 d of PH, silymarin administration have shown beneficial effect than SDOA consumption on liver regeneration of rats.

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Effects of clinoptilolite treatment on oxidative stress after partial hepatectomy in rats

Abstract: Clinoptilolite administration reduces oxidant activity and supports antioxidant response after partial hepatectomy.

Cited by 26 publications

References 32 publications

Counteraction of Apoptotic and Inflammatory Effects of Adriamycin in the Liver Cell Culture by Clinopitolite

Counteraction of Apoptotic and Inflammatory Effects of Adriamycin in the Liver Cell Culture by Clinopitolite

Effects of Dietary Supplementation with the Combination of Zeolite and Attapulgite on Growth Performance, Nutrient Digestibility, Secretion of Digestive Enzymes and Intestinal Health in Broiler Chickens

Comparing the regenerative effects of silymarin and apricot on liver regeneration after partial hepatectomy in rats

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