Effects of Citrullus colocynthis L. in a rat model of diabetic neuropathy

Ostovar, Mohadeseh; Akbari, Abolfazl; Anbardar, Mohammad Hossein; Iraji, Aida; Salmanpour, Mohsen; Ghoran, Salar Hafez; Heydari, Mojtaba; Shams, Mesbah

doi:10.1016/j.joim.2019.12.002

Cited by 39 publications

(23 citation statements)

References 32 publications

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“…Therefore, it is essential to choose a simple therapeutic approach to prevent zinc deficiency and the onset of oxidative stress, inflammation, and impaired glucose and lipid metabolism. Today, there is a growing emphasis on using the alternative medicine and the herbal remedies to treat and prevent metabolic diseases (Heydari et al., 2016; Nimrouzi et al., 2020; Ostovar et al., 2020). Many plants such as ginger contain phytochemical ingredients such as phenols and flavonoids that have antioxidant, anti‐lipidemic, and anti‐inflammatory activities (Akbari et al., 2020; Fathi et al., 2020).…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The combination of ginger powder and zinc supplement improves the fructose‐induced metabolic syndrome in rats by modulating the hepatic expression of NF‐κB, mTORC1, PPAR‐α SREBP‐1c, and Nrf2

Mustafa

Ali

et al. 2020

J. Food Biochem.

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Although studies have shown that ginger, as an herbal remedy and zinc are able to improve inflammation, oxidative stress, autophagy, and metabolism of lipid and glucose, their molecular mechanisms are unknown. Therefore, this study was aimed to examine the therapeutic effects of ginger with zinc supplement for eight weeks on fructose-induced metabolic syndrome (MS). Ninety-six adult male Sprague Dawley rats (220 g ± 20) were randomly assigned to twelve controlled and treated groups. After the last treatment session, the level of lipid profiles, glucose, insulin, and leptin as metabolic factors and liver enzymes as biomarkers to evaluate liver function in serum were measured. The level of antioxidant enzymes and lipid peroxidation to evaluate the oxidative status and the TNF-α level as a biomarker to assess the state of inflammation in liver were also measured. The level of zinc along with the expression of NF-κB, mTORC1, PPAR-α, SREBP-1c, and Nrf2 in liver was also evaluated. The level of metabolic factors and liver enzymes in serum along with lipid peroxidation and TNF-α in liver increased; zinc and antioxidant enzymes levels decreased in rats with MS compared to control rats (p < .05). The hepatic expression of SREBP-1c, NF-κB and mTORC1 were upregulated and the expression of PPAR-α and Nrf2 were downregulated in rats with MS compared to control rats (p < .05). Treatment with different doses of ginger, zinc, and the combination of them could improve metabolic, inflammatory oxidative stress factors, and expression of the above genes in rats with MS compared to the MS group (p < .05). It can be concluded that ginger, zinc, and the combination of them could improve oxidative damage, inflammation, and autophagy induced by fructose and could adjust the glucose and lipid metabolism and the homeostasis of zinc in rats with MS. Practical applications Due to the increasing prevalence of metabolic diseases, the use of plant compounds such as ginger has attracted widespread attention. Ginger as an herbal remedy with predominant pharmacological properties due to its availability, cheapness, and lack of side effects is also very popular for the treatment of metabolic disorders in folk How to cite this article:

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The combination of ginger powder and zinc supplement improves the fructose‐induced metabolic syndrome in rats by modulating the hepatic expression of NF‐κB, mTORC1, PPAR‐α SREBP‐1c, and Nrf2

Mustafa

Ali

et al. 2020

J. Food Biochem.

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“…Hyperinsulinemia and hyperglycemia are the main causes of free radical production and oxidative damage in patients with T2D. Increased free radical production leads to dyslipidemia, beta-cell dysfunction, and insulin resistance [18].…”

Section: Discussionmentioning

confidence: 99%

Association between Serum Levels of Vitamin D, Vitamin B12 and Folate with Oxidative Biomarkers in Diabetic Type 2 Patients in People in Erbil City: A Case-Control Study

Ibrahim¹,

Majeed²,

Yousif³

et al. 2020

DJM

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Background: Diabetes mellitus is the largest endocrine disorder in the world that refers to chronic hyperglycemia caused by impairment in both insulin secretion and action. Folate, vitamin B12, and vitamin D deficiency are related to the prevalence of type 2 diabetes mellitus. Objective: This study has been carried out to investigate the role of folate, vitamins B12, and D status during the progression of diabetic type 2 patients compared to non-diabetic control subjects. Patients and Methods: We measured the plasma levels of folate, vitamins B12, and D, along with blood glucose, HbA1c, and oxidative biomarkers in 50 diabetic type 2 patients and 50 healthy subjects used as a control group. Results: The findings revealed that the serum level of malondialdehyde (MDA) significantly increased in diabetic patients compared to healthy subjects, and the serum level of nitric oxide (NO) in T2D patients lower than in control. The concentration of vitamin D, B12, and folate in T2D patients significantly lower than non-T2D control. The results also showed a significant relationship between serum vitamin D, MDA, and NO with HbA1c, while there was an insignificant correlation between vitamin B12 and folate with HbA1c. Conclusion: The oxidative biomarkers and vitamins D, B12, and folate level can play an important role in the development and progression of T2D. Keywords: Oxidative Stress, Vitamin D, Vitamin B12, Folic acid, type 2 diabetes

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“…Quercetin was used as the reference antioxidant with the half‐maximal inhibitory concentration (IC 50 ) of 9.1 ± 0.42 µM. The results of the DPPH assay were expressed as IC 50 values by the Curve Expert software (for Windows, version 1.34) (Ostovar et al., 2020).…”

Section: Methodsmentioning

confidence: 99%

Effect of flaxseed oil on biochemical parameters, hormonal indexes and stereological changes in ovariectomized rats

Tanideh

Delavari

Farshad

et al. 2020

Veterinary Medicine & Sci

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The ovariectomized rat is a widely used preclinical model for studying postmenopausal and its complications. In this study, the therapeutic effect of flaxseed oil on the ovariectomized adult rats was investigated. Our results showed that biochemical parameters including calcium, oestrogen and progesterone levels increase 8 weeks after ovariectomy in rats. Also, the amount of alkaline phosphatase decreased significantly after 8 weeks compared with the OVX rat. The healing potential of flaxseed oil was proven by successfully recovering the affected tissue and preventing the unpleasant symptoms of ovariectomized rats. The biological effects of flaxseed oil may be due to high amounts of fatty acids, phytoestrogens and an array of antioxidants. The results suggest that flaxseed oil can mimic the action of oestrogen and can be a potential treatment for hormone replacement therapy (HRT).

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Effects of Citrullus colocynthis L. in a rat model of diabetic neuropathy

Cited by 39 publications

References 32 publications

The combination of ginger powder and zinc supplement improves the fructose‐induced metabolic syndrome in rats by modulating the hepatic expression of NF‐κB, mTORC1, PPAR‐α SREBP‐1c, and Nrf2

The combination of ginger powder and zinc supplement improves the fructose‐induced metabolic syndrome in rats by modulating the hepatic expression of NF‐κB, mTORC1, PPAR‐α SREBP‐1c, and Nrf2

Association between Serum Levels of Vitamin D, Vitamin B12 and Folate with Oxidative Biomarkers in Diabetic Type 2 Patients in People in Erbil City: A Case-Control Study

Effect of flaxseed oil on biochemical parameters, hormonal indexes and stereological changes in ovariectomized rats

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