Effects of Citrullus colocynthis and Momordica charantia hydro-ethanol extracts on lipid Profile of induced diabetic albino rats

Abstract

Diabetes is a condition in which glucose levels of blood become higher and can lead to many complications and death. The recent study was designed to check the hypo-glycemic effects of the Citrullus colocynthis and Momordica charantia leaves extract on streptozotocin (STZ) induced diabetic albino rats. For this purpose, 30 albino rats were divided into five treatment groups. Three groups were treated with plant extracts and the remaining two were given only a basal diet for 21 days. At the completion of the experiment, the body weight and glucose level of the rats were recorded and then dissected to collect blood and organs. The blood serum was separated by centrifugation to measure various chemical compounds. The organs’ weight was also recorded to check the animal performance. The recorded data were analyzed statistically by SAS and found that plant extracts separately or in combination significantly increased the bodyweight of rats than control groups, whereas, glucose level was decreased significantly as compared to control groups. It was observed that liver and pancreas weight were non-significantly and kidney weight was significantly decreased in treatment groups as compared to control groups. In our research, it was observed that the level of cholesterol (mg/dL), triglyceride (mg/dL), and Very low-density lipoprotein (mg/dL) were non-significantly lower in treatment groups than in control. However, a significant increase in high-density lipoprotein (mg/dL) and a significant decrease in the low-density lipoprotein (mg/dL) and HbA1c (%) was observed among treatment groups. It was concluded that supplementation of plant extracts in an animal’s diet can put health-promoting effects in diabetic rats.