Effects of Citalopram and Interpersonal Psychotherapy on Depression in Patients With Coronary Artery Disease

Frasure-Smith, Nancy; Koszycki, Diana; Zyl, Louis T. van; Baker, Brian; Swenson, J. Robert; Abramson, Beth L.; Dorian, Paul; Guertin, Marie-Claude

doi:10.1001/jama.297.4.367

Cited by 578 publications

(154 citation statements)

References 57 publications

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“…The SADHART and CREATE trials of antidepressants in depressed cardiac patients both showed the response rates for drug versus placebo were greater in patients who had a prior history of MDD, whereas patients experiencing their first major depressive episode showed no difference between drug and placebo (Lesperance, 2007;Glassman, 2002). It remains unclear whether this lack of greater drug response compared to placebo in the incident depressed group represents a different etiology of that depression (such as depression reactive to coronary disease severity, or vascular depression), thus explaining resistance to traditional depression treatment.…”

Section: Discussionmentioning

confidence: 99%

Incident and recurrent major depressive disorder and coronary artery disease severity in acute coronary syndrome patients

Goodman

Shimbo

Haas

et al. 2008

Journal of Psychiatric Research

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There is recent evidence that acute coronary syndrome (ACS) patients with first time incident major depressive disorder (MDD) and those with recurrent MDD represent different subtypes among individuals with ACS and comorbid depression. However, few studies have examined whether or not these subtypes differ in coronary artery disease (CAD) severity. We assessed whether those with incident MDD (in-hospital MDD and negative for history of MDD) or recurrent MDD (in-hospital MDD and a positive history of MDD) differ in angiographically documented CAD severity. Within 1 week of admission for ACS, 88 patients completed a clinical interview to assess current and past diagnosis of MDD. CAD severity was assessed in all patients by coronary angiography. A hierarchical regression analysis showed that neither in-hospital MDD status, nor history of MDD were significant predictors of CAD severity, but the interaction term between in-hospital MDD status and history of MDD was a significant predictor of CAD severity, after controlling for age, sex and ethnicity. Follow-up analyses showed that patients with first-time, incident MDD had significantly more severe CAD compared to patients with recurrent MDD (p = 0.043). To conclude, our study adds to the growing evidence that patients with incident MDD should be considered as a clinically distinct subtype from those with recurrent MDD. Possible mechanisms for differing CAD severity by angiogram between these two subtypes are proposed and implications for prognosis and treatment are discussed. KeywordsAcute Coronary Syndrome; Coronary Artery Disease; Myocardial Infarction; Angiogram; Incident Major Depressive Disorder; Recurrent Major Depressive Disorder Extensive research has shown that comorbid major depressive disorder (MDD) after an acute coronary syndrome (ACS) event is an independent prognostic marker of increased morbidity and mortality (Barth et al., 2004;van Melle et al., 2004 Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. (Thombs et al., 2006), and of these MDD patients, 50% or more have had depression symptoms in the past. Recent evidence suggests that patients who experience depression after ACS for the first time (incident depression) may represent a clinically distinct subtype when compared with depressed ACS patients who have had depressive symptoms in the past (recurrent depression). NIH Public AccessThe literature indicates that the extent to which comorbid MDD after ACS impacts future medical prognosis might be dependent on whether patients experience incident or recurrent depression. However, the evidence is mixed ...

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Section: Discussionmentioning

confidence: 99%

Incident and recurrent major depressive disorder and coronary artery disease severity in acute coronary syndrome patients

Goodman

Shimbo

Haas

et al. 2008

Journal of Psychiatric Research

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“…However, CBT, in contrast to antidepressants, did not improve the cardiac outcomes (71). Also, the CREATE trial, in addition to studying citalopram, found that interpersonal psychotherapy did not improve depressive symptoms, compared to active controls (63).…”

Section: Psychotherapymentioning

confidence: 99%

“…Similarly, the Cardiac Randomized Evaluation of Antidepressant and Psychotherapy Efficacy (CREATE) trial introduced citalopram as a safe and efficacious agent for patients with depression (63). It has been also shown that escitalopram can reduce the risk of post-ACS depression and improve quality of life among patients with ACS and depression (64,65).…”

Section: Pharmacotherapymentioning

confidence: 99%

A Narrative Review of the Relationship Between Coronary Heart Disease and Anxiety

Dahale

Menon

Jaisoorya

2017

Iran J Psychiatry Behav Sci

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Context: Coronary heart disease (CHD) is the most common cause of death and disability in the world. While the relationship between depression and CHD is well documented, anxiety remains understudied, despite its common cooccurrence. Evidence Acquisition: A PubMed (MEDLINE) search was conducted in order to find articles published between January 2000 and December 2015, using the following keywords: "coronary heart disease" and "anxiety". In total, 79 out of 1138 articles were considered relevant by consensus between the authors and were reviewed. Results: According to previous studies, anxiety is suggested to increase the risk of CHD. Anxiety is associated with an increase in cardiac complications, morbidity and mortality. Also, a lower quality of life has been described among patients after acute coronary syndrome, with a few studies reporting contradictory findings. Although studies on anxiety management in CHD are sparse, selective serotonin reuptake inhibitors have been shown to be relatively safe for patients. On the other hand, psychological interventions have not been adequately evaluated, although some studies have revealed their advantages. Conclusions: Evidence suggests that anxiety is associated with the development and course of CHD. Awareness and appropriate training in cardiology settings need to be prioritized to improve early identification and initiation of effective management.

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“…Dans cette étude « randomisée » contrôlée, effectuée auprès de 2 481 patients dans plusieurs centres hospitaliers et universitaires des États-Unis, les bénéfices du traitement psycho logique semblent disparaître après 30 mois. De plus, il n'y a pas de différence entre le groupe de traitement et le groupe témoin sur les taux de réhospitalisation ou de décès causés par des complications cardiaques subséquentes (Carney et al, 2004 ;ENRICHD, 2003 Lespérance et al, 2007). Comme leurs collègues américains, ils ont conclu que leur traitement psychologique n'a pas d'effet significatif sur la dépression des patients et que l'antidépresseur citralopam s'avère supérieur au traitement psychologique dans la gestion des symptômes de dépression.…”

Section: Traitement De La Dépressionunclassified

L’intégration d’un traitement psychologique en réadaptation cardiaque à l’Hôpital Montfort : une diminution des risques associés aux maladies cardiaques

Greenman

Morin-Turmel

Grenier

2010

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Les buts de cette étude étaient l’intégration et la mise à l’épreuve d’un traitement psychologique au sein du Service de réadaptation cardiaque à l’Hôpital Montfort. Des patients (hommes et femmes), âgés entre 35 et 85 ans, avec une maladie cardiaque et qui se plaignaient de symptômes d’anxiété et de dépression ont participé à cette étude. Les résultats suggèrent que la thérapie cognitivo-comportementale (TCC) peut réduire de façon significative les symptômes de dépression et d’anxiété chez les patients cardiaques. Dans notre échantillon (N = 11), les patients ayant suivi au moins dix séances de traitement ont présenté une diminution importante de leurs symptômes, et personne ne répondait aux critères d’un diagnostic de dépression ou d’anxiété après l’intervention.The goals of the study were to introduce and test a psychological treatment at the Montfort Hospital’s Cardiac Rehabilitation Service. The participants were male and female patients between the ages of 35 and 85 with heart disease who reported symptoms of anxiety and depression. The results suggest that cognitive-behavioural therapy (CBT) may significantly reduce symptoms of depression and anxiety in cardiac patients. In our sample (N = 11), patients completing at least 10 treatment sessions showed a significant decrease in their symptoms, and none met the criteria for a diagnosis of depression or anxiety after the treatment

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Effects of Citalopram and Interpersonal Psychotherapy on Depression in Patients With Coronary Artery Disease

Cited by 578 publications

References 57 publications

Incident and recurrent major depressive disorder and coronary artery disease severity in acute coronary syndrome patients

Incident and recurrent major depressive disorder and coronary artery disease severity in acute coronary syndrome patients

A Narrative Review of the Relationship Between Coronary Heart Disease and Anxiety

L’intégration d’un traitement psychologique en réadaptation cardiaque à l’Hôpital Montfort : une diminution des risques associés aux maladies cardiaques

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