Effects of circulating member B of the family with sequence similarity 3 on the risk of developing metabolic syndrome and its components: A 5‐year prospective study

Abstract

Aims/IntroductionMember B of the family with sequence similarity 3 (FAM3B), also known as pancreatic‐derived factor, is mainly synthesized and secreted by islet β‐cells, and plays a role in abnormal metabolism of glucose and lipids. However, the prospective association of FAM3B with metabolic disorders remains unclear. The present study aimed to reveal the predictive relationship between pancreas‐specific cytokine and metabolic syndrome (MetS).Materials and MethodsA total of 210 adults (88 men and 122 women) without MetS, aged between 40 and 65 years, were recruited and received a comprehensive health examination. Baseline serum FAM3B levels were determined by sandwich enzyme‐linked immunosorbent assay. Subsequently, all participants underwent a follow‐up examination after 5 years. MetS was identified in accordance with the International Diabetes Federation criteria.ResultsDuring follow up, 35.7% participants developed MetS. In comparison with the non‐MetS group, participants with MetS had an increased serum FAM3B at baseline (21.85 ng/mL [19.38, 24.17 ng/mL] vs 28.56 ng/mL [25.32, 38.10 ng/mL], P < 0.001). Moreover, serum FAM3B was significantly associated with variations in fasting plasma insulin (r = −0.306, P < 0.001), homeostasis model assessment of β‐cell function (r = −0.328, P < 0.001) and homeostasis model assessment of insulin resistance (r = −0.191, P = 0.006). Furthermore, a positive correlation between baseline FAM3B and the incidence of MetS was observed, even after multivariable adjustment (relative risk 1.23 [1.15, 1.31], P < 0.001). Furthermore, the optimal cut‐off values of FAM3B was 23.98 ng/mL for predicting MetS based on the Youden Index.ConclusionsElevated circulating FAM3B might be considered as a predictor of newly‐onset MetS and its progression.

The cytokine FAM3B/PANDER is an FGFR ligand that promotes posterior development in Xenopus

“…First, FAM3B has been suggested to be a causal gene for type 2 diabetes. In humans and mice, increased circulating FAM3B/PANDER levels are associated with hyperglycemia, pancreatic β-cell dysfunction, and insulin resistance (54)(55)(56)(57)(58). Second, FAM3B has been reported to act as an oncogene that, when expressed, promotes the progression of several types of cancer, including colon cancer, prostate cancer, esophageal cancer, and gastric cancer (20)(21)(22)(23).…”

FAM3B (PANDER) functions as a co‐activator of FOXO1 to promote gluconeogenesis in hepatocytes

“…17 Another clinical report confirmed that serum PANDER level is increased in patients with metabolic syndrome, and an increase in circulating PANDER level can predict metabolic syndrome in Chinese population. 29 An increase in serum PANDER levels have been reported to be associated with pancreatic β cell dysfunction and hyperglycemia in other races. 18,19 Overall, these important clinical studies revealed that circulating PANDER is a unique diagnostic biomarker for diabetes and metabolic syndrome, and it is necessary to further study the mechanism(s) of PANDER in the regulation of glucose and lipid metabolism.…”

Combined Effects of Dyslipidemia and High Adiposity on the Estimated Glomerular Filtration Rate in a Middle-Aged Chinese Population

“…The data analyzed in the present study were derived from the baseline population of a community-based cohort study in Shenyang, Liaoning Province. [13][14][15] Seven hundred fifty subjects aged 40-65 years were recruited for the health examination project [Nanzhan Community Survey of Metabolic Disorders, NOVEMBER Study]. The study was approved by the Ethics Committee of the First Hospital of China Medical University.…”