Effects of Cigarette Smoking On Lipid Peroxidation and Serum Antioxidant Vitamins

Bello, Hauwa’u A.; Dandare, Abdullahi; Danmaliki, Gaddafi I.

doi:10.9790/3008-1202044044

Cited by 7 publications

(5 citation statements)

References 15 publications

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“…In addition, spectrophotometer happens to be one of the methods available in the institution. According to Bello et al 27 and Kim et al 26 , this method provides accurate and dependable findings.…”

Section: Discussionmentioning

confidence: 95%

“…The side stream smoke will cause damage to fat membranes that are sensitive to oxidative stress, which will worsen with time. 24 27 The increase of MDA level in rats exposed to sidestream cigarette smoke occurs because ROS would cause DNA damage and reduce oxygenation in blood. 26 Nicotine in cigarette smoke can cause vasoconstriction of blood vessels because it triggers the sympathetic ganglion in the brain to produce catecholamine, which then stimulates α receptors in blood vessels.…”

Section: Discussionmentioning

confidence: 99%

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Malondialdehyde Level and Tissue Apoptosis Count as an Early-Detection Marker of Oral Potentially Malignant Disorders

et al. 2022

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Objectives The malondialdehyde (MDA) level and TA count represent the progression of oral potentially malignant disorders (OPMD) to malignancy and thus may be used as an indicator of oral epithelial dysplasia (OED). This study aimed to determine the MDA level and tissue apoptosis (TA) count in oropharyngeal tissue of Wistar rats exposed to sidestream cigarette smoke. Materials and Methods Wistar rats were divided into three groups: T4 group (4-week cigarette smoke exposure), T8 group (8-week cigarette smoke exposure), and control group, which was not exposed to cigarette smoke. The oropharyngeal tissue of the rats from each group was examined histopathologically to count the number of apoptotic cells, and then the blood serum was made to measure the MDA level. Statistical Analysis Bonferroni test was performed to see the differences in each group for MDA level. While the data from tissue apoptosis were analyzed using Mann-Whitney U test for the significance. All data were considered significant if p < 0.05. Results The MDA level and TA count increased as the duration of cigarette smoke exposure increased. In the T8 group, the MDA level and TA count were significantly higher compared with the T4 and control groups with a p-value < 0.05. Conclusions Exposure to sidestream cigarette smoke increased the TA count and MDA level in the oropharyngeal tissue of Wistar rats. The TA count and MDA level may be used as markers of OPMD.

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Malondialdehyde Level and Tissue Apoptosis Count as an Early-Detection Marker of Oral Potentially Malignant Disorders

et al. 2022

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“…Additionally, a higher metabolic rate could be the cause of decreased body weight and BMI 20 . Another way of this result may be to generate free radicals in tissues because of increasing lipid peroxidation by smoking 21 .…”

Section: Discussionmentioning

confidence: 99%

Analysis of Endogenous Antioxidants of Rat Blood Exposed to E-Cigarette

Lisdiana¹,

Harini²,

Widiyaning³

2022

J. of Biological Sciences

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Background and Objective: E-cigarettes (e-cig) produce smoke with high levels of free oxidants, which can be eliminated by endogenous antioxidants such as glutathione peroxidase (GPx) and catalase (CAT) in the human body. The GPx catabolizes hydrogen peroxide (H 2 O 2 ), while catalase counteracts free radicals by catalyzing H 2 O 2 into H 2 O and O 2 . However, oxidative stress is shown in the imbalance condition between free oxidants and endogenous antioxidants. The effect of e-cigarette smoking on the human body has not been discovered. Therefore, this research aimed to analyze the levels of GPx and CAT in the rat blood exposed to e-cig. Materials and Methods: The exposure to smoke with nicotine 3, 6 and 9 mg was applied to 30 rats divided into five groups for 30 days. The analysis results by one-way ANOVA showed significant differences in the GPx and CAT levels between the control and treatment groups. Nicotine at 9 mg gave the GPx level at 40.25±2.03 U mgG 1 and CAT at 2.46±0.50 nmol mLG 1 . Results: The results indicated that e-cigarette smoke reduced the levels of endogenous antioxidants in rat blood. Moreover, the body weight of rats increased and decreased due to the unstable metabolic rate. Conclusion: Exposure to e-cigarette smoke has an effect on reducing glutathione peroxidase (GPx) and catalase (CAT) levels in rat blood.

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“…Therefore, lipid peroxidation is one of the major consequences of oxidative stress. Cigarette smoking for instance, which is an environmental factor that triggers RA development, is a source of exogenous lipid peroxidation products, which are capable not only of promoting the depletion of serum antioxidants that normally act as radical scavengers, but also of affecting directly biological macromolecules, by introducing third-party carbonyl groups into a wide array of proteins, such as cytoskeletal proteins, glycolytic enzymes, antioxidant enzymes, and endoplasmic reticulum proteins, and by attacking the free amino-groups of DNA bases [ 54 , 55 , 56 ]. Lipids, including phospholipid oxidation products, are important in the modulation in an inflammatory response [ 57 ].…”

Section: Oxidative Stress In Rheumatoid Arthritismentioning

confidence: 99%

Insights in the Role of Lipids, Oxidative Stress and Inflammation in Rheumatoid Arthritis Unveiled by New Trends in Lipidomic Investigations

et al. 2021

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Rheumatoid arthritis (RA) is a highly debilitating chronic inflammatory autoimmune disease most prevalent in women. The true etiology of this disease is complex, multifactorial, and is yet to be completely elucidated. However, oxidative stress and lipid peroxidation are associated with the development and pathogenesis of RA. In this case, oxidative damage biomarkers have been found to be significantly higher in RA patients, associated with the oxidation of biomolecules and the stimulation of inflammatory responses. Lipid peroxidation is one of the major consequences of oxidative stress, with the formation of deleterious lipid hydroperoxides and electrophilic reactive lipid species. Additionally, changes in the lipoprotein profile seem to be common in RA, contributing to cardiovascular diseases and a chronic inflammatory environment. Nevertheless, changes in the lipid profile at a molecular level in RA are still poorly understood. Therefore, the goal of this review was to gather all the information regarding lipid alterations in RA analyzed by mass spectrometry. Studies on the variation of lipid profile in RA using lipidomics showed that fatty acid and phospholipid metabolisms, especially in phosphatidylcholine and phosphatidylethanolamine, are affected in this disease. These promising results could lead to the discovery of new diagnostic lipid biomarkers for early diagnosis of RA and targets for personalized medicine.

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Effects of Cigarette Smoking On Lipid Peroxidation and Serum Antioxidant Vitamins

Cited by 7 publications

References 15 publications

Malondialdehyde Level and Tissue Apoptosis Count as an Early-Detection Marker of Oral Potentially Malignant Disorders

Malondialdehyde Level and Tissue Apoptosis Count as an Early-Detection Marker of Oral Potentially Malignant Disorders

Analysis of Endogenous Antioxidants of Rat Blood Exposed to E-Cigarette

Insights in the Role of Lipids, Oxidative Stress and Inflammation in Rheumatoid Arthritis Unveiled by New Trends in Lipidomic Investigations

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