Effects of chronically high doses of the anabolic androgenic steroid, testosterone, on intermale aggression and sexual behavior in male rats

Lumia, Augustus R.; Thorner, Kim; McGinnis, Marilyn Y.

doi:10.1016/0031-9384(94)90142-2

Cited by 89 publications

(53 citation statements)

References 41 publications

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“…It was found that long-term exposure to steroids was associated with a number of pathological lesions localized in heart, liver and kidney of mice (Bronson and Matherne 1997). Similar to the previously cited eVects in humans, behavior was also altered by the administration of AAS, manifesting an increased aggression in rats (Clark and Barber 1994;Lumia et al 1994). A decrease in HDL (Leeds et al 1986) and a signiWcant right ventricular hypertrophy (Moore et al 1978) were also found in AAS-treated rats.…”

Section: Introductionsupporting

confidence: 64%

Diverse effects of stanozolol in C57BL/6J and A/J mouse strains

Lionikas

Blizard

2008

Eur J Appl Physiol

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Utilizing a rat model of ischemic stroke, we have previously shown that sensory stimulation can completely protect rats from impending ischemic damage of cortex if this treatment is delivered within the first two hours post-permanent middle cerebral artery occlusion (pMCAo). The current study sought to extend our findings in rats to mice, which would allow new avenues of research not available in rats. Thus, young adult C57BL/6J and CD1 mice were tested for protection from ischemic stroke with the same protective sensory stimulation based treatment. Cortical activity and blood flow were assessed with intrinsic signal optical imaging (ISOI) and laser speckle imaging (LSI), respectively, and histological analysis (TTC) was performed at the completion of the experiments. Standing in stark contrast to the positive results observed in rats, in both strains we found that there were no differences between treated and untreated mice at 24 hours post-pMCAo in terms of infarct volume, negative functional imaging results, and major reduction in retrograde collateral blood flow as compared to pre-pMCAo baseline and surgical controls. Also, no differences were found between the strains in terms of theses variables. Potential reasons for the differences between rats and mice are discussed.

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Section: Introductionsupporting

confidence: 64%

Diverse effects of stanozolol in C57BL/6J and A/J mouse strains

Lionikas

Blizard

2008

Eur J Appl Physiol

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“…This behavior increases dramatically after sexual maturity and becomes more severe as the rats age. Adult agonistic behavior is called serious fighting and is known to be enhanced by androgenization (e.g., Clark and Barber 1994;Lumia et al 1994; see also Thor and Holloway 1984 for review), a fact that is consistent with the results of studies on development. Aggressive behavior is also enhanced by isolation (e.g., Swanson and Schuster 1987;Wongwitdecha and Marsden 1996).…”

Section: Introductionmentioning

confidence: 60%

Characteristics of social interaction between unfamiliar male rats (Rattus norvegicus): comparison of juvenile and adult stages

Yamada-Haga

2002

J Ethol

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Social interaction between juvenile male rats that were unfamiliar with one another (JNI) was compared with that of adult unfamiliar animals (ANI). In their home cages, subjects were confronted with a stimulus conspecific and their agonistic behavior patterns were analyzed. It was found that behaviors that characterize "play fighting" (pouncing, submissive posture, on-top posture, etc.) were observed more in JNI than in ANI, whereas behaviors found in serious fighting (pawing, upright posture, etc.) were shown more in ANI. Analyses of the transitions between behaviors also revealed that the transitions constituting play fighting were found only in JNI. On the other hand, transitions that characterize serious fighting were shown in both JNI and ANI. These findings are discussed along with those of a previous study that observed the agonistic behavior between littermates, and the existence of some cue that signals the play-fighting situation among rats is suggested.

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“…In mice, although no relationship was found between dominance and testosterone, subordinate individuals had lower testis and seminal vesicle weights [Selmanoff et al, 1977], whereas intermale aggression was correlated with serum testosterone [Maxson et al, 1983]. Testosterone-dependent social aggression has been described in rats [Albert et al, 1992;Breuer et al, 2001;Lumia et al, 1994]. In addition, natural variations in basal testosterone can affect competitive ability in wild house mice [Zielinski and Vandenberg, 1993].…”

Section: Discussionmentioning

confidence: 99%

“…Indeed the importance of the relations among gonadal androgens in favoring the adaptation to environmental pressure, including social organization, is well known [Brain, 1980;Ramenofsky, 1984]. Testosterone-dependent intermale social aggression has been demonstrated in the male rat [Albert et al, 1986[Albert et al, , 1992Breuer et al, 2001;Lumia et al, 1994]. Aggression induced by androgens is modulated by the social environment [Albonetti and Farabollini, 1994;Lumia, 1972;Ruis et al, 1999].…”

Section: Introductionmentioning

confidence: 99%

Behavioral effects of testosterone in relation to social rank in the male rabbit

Briganti

Seta

Fontani

et al. 2003

Aggressive Behavior

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The role of gonadal androgens in favoring the adaptation to environmental pressure, including social organization, is well known. In the rabbit, testosterone administration increases marking behavior, and its level can be affected by agonistic interaction. In this experiment, we studied the effect of subcutaneous administration of testosterone propionate (TP) (3 mg/d for 6 days) in male rabbits belonging to the same social group (6 groups of 4 animals). In 2 additional groups (4 animals each), males were injected with almond oil. The animals were observed for 6 days in seminatural conditions, then treated with TP (or oil) and observed for another 6 days. The dominant/subordinate frequency ratio of behavioral patterns was used to rank the animals. The testosterone plasma concentration was correlated with agonistic behavior after the first period of social interaction. A significant increase of marking, digging, and defensive activity was observed after TP administration in all animals independent of rank, whereas this increase was not present in animals treated with oil. Agonistic and interactive behaviors increased significantly after TP treatment only in the first-ranking animals. This indicates the influence of social rank in the modification of behaviors involving interactions among subjects Aggr. Behav. 29:269-278,

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Effects of chronically high doses of the anabolic androgenic steroid, testosterone, on intermale aggression and sexual behavior in male rats

Cited by 89 publications

References 41 publications

Diverse effects of stanozolol in C57BL/6J and A/J mouse strains

Diverse effects of stanozolol in C57BL/6J and A/J mouse strains

Characteristics of social interaction between unfamiliar male rats (Rattus norvegicus): comparison of juvenile and adult stages

Behavioral effects of testosterone in relation to social rank in the male rabbit

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