Effects of chronic uranium exposure on life history and physiology of Daphnia magna over three successive generations

Massarin, Sandrine; Alonzo, Frédéric; Garcia‐Sanchez, L.; Gilbin, Rodolphe; Garnier‐Laplace, Jacqueline; Poggiale, Jean-Christophe

doi:10.1016/j.aquatox.2010.05.006

Cited by 83 publications

(70 citation statements)

References 61 publications

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“…In some cases, tolerance is not achieved or transgenerational effects are not clear, for example after exposure of F0 to the plastic additive and surfactant p-nonylphenol (Tanaka and Nakanishi, 2002) or the pharmaceuticals carbamazepine, diclofenac, 17␣-ethinylestradiol and metroprolol (Dietrich et al, 2010). Even a magnification of the detrimental effect has been shown, as was found with lauryl sulphate (Le Blanc, 1982), the pesticides tetradifon (Villarroel et al, 2000) and diazinon (Sánchez et al, 2000), the endocrine disruptors 17-oestradiol E2, diethylstilbestrol, bisphenol A and 4-nonylphenol (Brennan et al, 2006), uranium (Massarin et al, 2010) and the herbicide glyphosate (Papchenkova et al, 2009). It is important to remark that in this last set of studies, where a magnified effect was found in the subsequent generations, a clear effect was not found in the parental generations, highlighting the importance of multigenerational approaches in ecotoxicology to the understanding and evaluation of the impact of chemicals in the ecosystem.…”

Section: Discussionmentioning

confidence: 99%

Transgenerational effects of microcystin-LR onDaphnia magna

Ortiz-Rodríguez

Dao

Wiegand

2012

Journal of Experimental Biology

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SUMMARYAnthropogenic and climate factors increase the frequency of problematic cyanobacterial blooms in freshwater. Among other toxins, some cyanobacteria produce microcystins (MCs), which inhibit phosphatases type 1 and type 2A and provokes oxidative stress. Toxic cyanobacteria affect the growth, survival and reproduction of zooplankton, particularly those from the genus Daphnia, which have a central position in pelagic food webs. However, one possibility to ameliorate effects is to biotransform MC via glutathione S transferase (GST) to a less toxic glutathione conjugate. This process was hypothesised to underlie the ability of Daphnia to withstand MC and to explain the enhanced tolerance of the offspring from mothers exposed to toxic cyanobacteria. Thus we conducted multigenerational experiments with D. magna, exposing the parental generation to MC for 1 or 7days and determining the enzyme-mediated tolerance to MC in their offspring by assessing the acute effect of MC on biotransformation and antioxidant and metabolism enzymes, and through 21day chronic tests on toxicity and growth. Seven days of exposure of the parental generation to MC induced higher activity of GST and malate dehydrogenase in the offspring and enabled them to increment the catalase activity when challenged with MC, whereas 1day of exposure of the parental generation did not. Offspring from non-exposed and 1-day-exposed mothers suffered decreased survival when exposed to MC compared with offspring from 7-day-exposed mothers; survival was correlated with the elevated activity of GST, malate dehydrogenase and catalase, suggesting maternal transfer of activation factors. However, increased survival occurred at the expense of individual growth. These results suggest that transgenerational effects are provoked by MC in D. magna, which may explain the observed acquirement of enhanced tolerance over generations.Key words: microcystin, cyanobacterial toxin, transgenerational effect, Daphnia, zooplankton. THE JOURNAL OF EXPERIMENTAL BIOLOGY 2796 cyanobacteria on Daphnia are reflected by, for example, reduced growth, survival and reproduction (Lampert, 1981; Demott et al., 1991;Hietala et al., 1995;Nogueira et al., 2004;Trubetskova and Haney, 2006; Dao et al., 2010). However, one possible way to reduce toxic effects is to biotransform the toxin MC-LR by conjugation to the tripeptide glutathione (GSH) via the enzyme glutathione S transferase (GST) (Pflugmacher et al., 1998). MCs are conjugated to GSH through the terminal methylene of N-methyldehydroalanine (Kondo, 1992), which is the moiety that binds to the active center of protein phosphatases (MacKintosh, 1995). The resulting conjugate is less toxic (Metcalf et al., 2000) and more hydrophilic, for easier transportation or excretion (Pflugmacher et al., 2001). This MC-LR detoxification process has been described in several aquatic organisms ranging from plants to invertebrates (including Daphnia magna) to fish (Pflugmacher et al., 1998;Wiegand and Pflugmacher, 2005). Three major families of prote...

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Section: Discussionmentioning

confidence: 99%

Transgenerational effects of microcystin-LR onDaphnia magna

Ortiz-Rodríguez

Dao

Wiegand

2012

Journal of Experimental Biology

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“…Analysis of uranium toxicity data on Daphnia magna using deb theory concluded that assimilation decreased in response to water-borne exposure to U (Massarin et al, 2010(Massarin et al, , 2011. Their study showed that effects of uranium on growth and reproduction were captured equally well when assuming a decrease in assimilation or an increase in somatic maintenance in the first two generations, but that effects on the third generation were better characterized by a decrease in assimilation.…”

Section: Reproductive Toxicologymentioning

confidence: 99%

Effects of uranium on the metabolism of zebrafish, Danio rerio

et al. 2012

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The increasing demand for nuclear energy results in heightened levels of uranium (U) in aquatic systems which present a potential health hazard to resident organisms. The aim of this study was to mechanistically assess how chronic exposure to environmentally relevant concentrations of U perturbs the complex interplay between feeding, growth, maintenance, maturation and reproduction throughout the life-cycle of an individual. To this end we analysed literature-based and original zebrafish toxicity data within a same mass and energy balancing conceptual framework. U was found to increase somatic maintenance leading to inhibition of spawning as well as increase hazard rate and costs for growth during the early life stages. The fish's initial conditions and elimination through reproduction greatly affected toxico-kinetics and effects. We demonstrate that growth and reproduction should be measured on specific individuals since mean values were hardly interpretable. The mean food level differed between experiments, conditions and individuals. This last 'detail' contributed substantially to the observed variability by its combined effect on metabolism, toxic effects and toxico-kinetics. The significance of this work is that we address exactly how these issues are related and derive conclusions which are independent of experimental protocol and coherent with a very large body of literature on zebrafish eco-physiology.

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“…Nevertheless, these results do not account for diapause as an evolutionary strategy to face hazardous conditions. Within populations, individuals are indirectly affected by transgenerational transmission of the effects of contaminants (Massarin et al 2010). Tolerance to different adverse environmental conditions depends upon the history of parental generations.…”

Section: Introductionmentioning

confidence: 99%

Diapause as escape strategy to exposure to toxicants: response of Brachionus calyciforus to arsenic

Aránguiz-Acuña

Serra

2016

Ecotoxicology

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Invertebrate organisms commonly respond to environmental fluctuation by entering diapause. Production of diapause in monogonont rotifers involves a previous switch from asexual to partial sexual reproduction. Although zooplankton have been used in ecotoxicological assays, often their true vulnerability to toxicants is underestimated by not incorporating the sexual phase. We experimentally analyzed traits involved in sexual reproduction and diapause in the cyclically parthenogenetic freshwater rotifer, Brachionus calyciflorus, exposed to arsenic, a metalloid naturally found in high concentrations in desert zones, focusing on the effectiveness of diapause as an escape response in the face of an adverse condition. Addition of sublethal concentrations of arsenic modified the pattern of diapause observed in the rotifer: investment in diapause with arsenic addition peaked earlier and higher than in non-toxicant conditions, which suggests that sexual investment could be enhanced in highly stressed environmental conditions by increased responsiveness to stimulation. Nevertheless, eggs produced in large amount with arsenic, were mostly low quality, and healthy-looking eggs had lower hatching success, therefore it is unclear whether this pattern is optimum in an environment with arsenic, or if rather arsenic presence in water bodies disturbs the optimal allocation of offspring entering diapause. We observed high accumulation of arsenic in organisms exposed to constant concentration after several generations, which suggests that arsenic may be accumulated transgenerationally. The sexual phase in rotifers may be more sensitive to environmental conditions than the asexual one, therefore diapause attributes should be considered in ecotoxicological assessment because of its ecological and evolutionary implications on lakes biodiversity.

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Effects of chronic uranium exposure on life history and physiology of Daphnia magna over three successive generations

Cited by 83 publications

References 61 publications

Transgenerational effects of microcystin-LR onDaphnia magna

Transgenerational effects of microcystin-LR onDaphnia magna

Effects of uranium on the metabolism of zebrafish, Danio rerio

Diapause as escape strategy to exposure to toxicants: response of Brachionus calyciforus to arsenic

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