Effects of chronic treatment with gold nanoparticles on inflammatory responses and oxidative stress in Mdx mice

Haupenthal, Daniela Pacheco dos Santos; Possato, Jonathann Corrêa; Zaccaron, Rubya Pereira; Mendes, Carolini; Rodrigues, Matheus Scarpatto; Nesi, Renata Tiscoski; Pinho, Ricardo A.; Feuser, Paulo Emílio; Machado-de-Ávila, Ricardo Andrez; Comim, Clarissa M.; Silveira, Paulo César Lock

doi:10.1080/1061186x.2019.1613408

Cited by 21 publications

(21 citation statements)

References 66 publications

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“…Moreover, it has been reported that 20 nm GNPs significantly increase the reduced activities of superoxide dismutase (SOD) and catalase (CAT) in Mdx-treated mice. Therefore, GNPs exert their antioxidant activity by decreasing nitrogen species and ROS production, improving antioxidant activity, and subsequently reducing oxidative damage, inflammation, and pro-apoptotic proteins [ 111 ]. Furthermore, both antioxidant and anti-inflammatory effects of GNPs have been shown by a decreased expression of CD68, a membrane protein of macrophage, and an increased expression of SOD in an epithelial lesion model [ 112 ].…”

Section: Gold Nanoparticles For Immune Stimulation; Focus On Anti-inflammatory and Antioxidant Propertiesmentioning

confidence: 99%

Gold Nanoparticles: Multifaceted Roles in the Management of Autoimmune Disorders

et al. 2021

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Gold nanoparticles (GNPs) have been recently applied for various diagnostic and therapeutic purposes. The unique properties of these nanoparticles (NPs), such as relative ease of synthesis in various sizes, shapes and charges, stability, high drug-loading capacity and relative availability for modification accompanied by non-cytotoxicity and biocompatibility, make them an ideal field of research in bio-nanotechnology. Moreover, their potential to alleviate various inflammatory factors, nitrite species, and reactive oxygen production and the capacity to deliver therapeutic agents has attracted attention for further studies in inflammatory and autoimmune disorders. Furthermore, the characteristics of GNPs and surface modification can modulate their toxicity, biodistribution, biocompatibility, and effects. This review discusses in vitro and in vivo effects of GNPs and their functionalized forms in managing various autoimmune disorders (Ads) such as rheumatoid arthritis, type 1 diabetes, and multiple sclerosis.

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Section: Gold Nanoparticles For Immune Stimulation; Focus On Anti-inflammatory and Antioxidant Propertiesmentioning

confidence: 99%

Gold Nanoparticles: Multifaceted Roles in the Management of Autoimmune Disorders

et al. 2021

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“…Nonetheless, the fact that treatment with antioxidants did not improve DMD pathology raises concerns whether oxidative stress is an essential part of DMD pathogenesis. In this regard, recently published studies using either deferoxamine or gold nanoparticles to treat mdx mice have yielded promising results [ 160 , 161 ]. Taken together, there is a need for both pre-clinical and clinical trials to evaluate the therapeutic potential of drugs aiming to reduce oxidative stress in DMD.…”

Section: Oxidative Stress Responsementioning

confidence: 99%

Cellular Stress in the Pathogenesis of Muscular Disorders—From Cause to Consequence

Mensch

Zierz

2020

IJMS

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Cellular stress has been considered a relevant pathogenetic factor in a variety of human diseases. Due to its primary functions by means of contractility, metabolism, and protein synthesis, the muscle cell is faced with continuous changes of cellular homeostasis that require rapid and coordinated adaptive mechanisms. Hence, a prone susceptibility to cellular stress in muscle is immanent. However, studies focusing on the cellular stress response in muscular disorders are limited. While in recent years there have been emerging indications regarding a relevant role of cellular stress in the pathophysiology of several muscular disorders, the underlying mechanisms are to a great extent incompletely understood. This review aimed to summarize the available evidence regarding a deregulation of the cellular stress response in individual muscle diseases. Potential mechanisms, as well as involved pathways are critically discussed, and respective disease models are addressed. Furthermore, relevant therapeutic approaches that aim to abrogate defects of cellular stress response in muscular disorders are outlined.

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“…Indeed, gold colloids have been thought to cure various diseases for many centuries, and recent studies have demonstrated that this effect is mediated by inhibition of NF-κB activation 13 . Different studies showed a similar effect in the case of Au NPs in vitro and in vivo, this effect being usually mediated by antioxidant properties 14 – 16 . However, other studies showed opposite results.…”

Section: Discussionmentioning

confidence: 69%

“…However, other studies showed opposite results. For example, Ng et al 16 showed that incubation of human bronchial epithelial cells with 50 µg ml −1 of 20 nm Au NPs activated NF-κB in bronchial epithelial cells. Close results were shown in other cell types 17 , 18 .…”

Section: Discussionmentioning

confidence: 99%

Anti-inflammatory effect of gold nanoparticles supported on metal oxides

Fujita

Zysman

Elgrabli

et al. 2021

Sci Rep

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Gold (Au) can be deposited as nanoparticles (NPs) smaller than 10 nm in diameter on a variety of metal oxide (MOx) NPs. Au/MOx have high catalytic performance and selective oxidation capacity which could have implications in terms of biological activity, and more specifically in modulation of the inflammatory reaction. Therefore, the aim of this study was to examine the effect of Au/TiO2, Au/ZrO2 and Au/CeO2 on viability, phagocytic capacity and inflammatory profile (TNF-α and IL-1β secretion) of murine macrophages. The most important result of this study is an anti-inflammatory effect of Au/MOx depending on the MOx nature with particle internalization and no alteration of cell viability and phagocytosis. The effect was dependent on the MOx NPs chemical nature (Au/TiO2 > Au/ZrO2 > Au/CeO2 if we consider the number of cytokines whose concentration was reduced by the NPs), and on the inflammatory mediator considered. The effect of Au/TiO2 NPs was not related to Au NPs size (at least in the case of Au/TiO2 NPs in the range of 3–8 nm). To the best of our knowledge, this is the first demonstration of an anti-inflammatory effect of Au/MOx.

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Effects of chronic treatment with gold nanoparticles on inflammatory responses and oxidative stress in Mdx mice

Cited by 21 publications

References 66 publications

Gold Nanoparticles: Multifaceted Roles in the Management of Autoimmune Disorders

Gold Nanoparticles: Multifaceted Roles in the Management of Autoimmune Disorders

Cellular Stress in the Pathogenesis of Muscular Disorders—From Cause to Consequence

Anti-inflammatory effect of gold nanoparticles supported on metal oxides

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