Effects of chronic restraint stress and estradiol on open field activity, spatial memory, and monoaminergic neurotransmitters in ovariectomized rats

Bowman, Rachel E.; Ferguson, Deveroux; Luine, V. N.

doi:10.1016/s0306-4522(02)00156-2

Cited by 209 publications

(171 citation statements)

References 57 publications

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“…Consequently, this study did not support the global interpretation that CA3 morphology predicts spatial memory, as demonstrated in male rats. Although numerous studies have suggested that ovarian hormones contribute to functional spatial memory in stressed females (Bowman et al, 2002;Bisagno et al, 2003), we have demonstrated that ovarian hormones are not necessary for intact spatial memory. Overall, these findings suggest that the CA1 region may play an important role in spatial memory ability and that it may override the contribution of the CA3 region following chronic stress in females.…”

Section: Discussioncontrasting

confidence: 75%

“…This interpretation is supported by impaired habituation to novel environments in male rats following psychosocial stress (Park et al, 2001). Another interpretation is that chronic stress facilitated females' spatial memory, similar to the facilitative effects found in the radial arm maze and object placement tasks (Bowman et al, 2001(Bowman et al, , 2002Beck and Luine, 2002). This diversity of tasks that use novelty or appetitive training suggests that performance in females is facilitated by chronic stress through neural mechanisms underlying spatial memory.…”

Section: Effects Of Chronic Stress On the Y-mazementioning

confidence: 78%

“…Young and aged rats who experience long-term OVX (1.5-6 months) display significantly better performance in the water radial-arm maze than their sham counterparts, most likely from the hormonal shift occurring after OVX (Bimonte-Nelson et al, 2003). Chronic restraint stress affects the dopaminergic system in the prefrontal cortex, and these stress-dependent changes are not demonstrated in gonadally-intact stressed females (Bowman et al, 2002). Three weeks following OVX, females have a faster recovery of adrenocorticotropin hormone (ACTH) and CORT response to shock stress compared with females given chronic estrogen replacement (Burgess and Handa, 1992).…”

Section: Effects Of Chronic Stress On the Y-mazementioning

confidence: 97%

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Chronic stress enhances spatial memory in ovariectomized female rats despite CA3 dendritic retraction: Possible involvement of CA1 neurons

et al. 2005

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Emerging data report sex differences in how the brain responds to chronic stress. Here, we investigated the effects of chronic restraint stress (6 h/day/21 days) on hippocampal morphology and function in ovariectomized female rats. Chronic restraint stress caused CA3 apical dendritic retraction in short-and long-shafted neurons, while it reduced basal dendritic arbors in long-shafted neurons only. Chronic restraint did not affect CA1 dendritic arborization, although it increased the proportion of CA1 spine heads compared with controls. Both stressed and control animals performed well on the Y-maze, a spatial memory task. However, chronic stress enhanced Y-maze performance compared with controls, which may reflect facilitated spatial memory or reduced habituation. Ymaze performance correlated with CA1 spine head proportion. This relationship suggests that spatial ability in females may be more tightly coupled with CA1 morphology, which may override the influence of CA3 dendritic retraction. Thus, this research provides additional evidence that CA3 morphology does not always parallel spatial memory.

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Section: Discussioncontrasting

confidence: 75%

Section: Effects Of Chronic Stress On the Y-mazementioning

confidence: 78%

Section: Effects Of Chronic Stress On the Y-mazementioning

confidence: 97%

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Chronic stress enhances spatial memory in ovariectomized female rats despite CA3 dendritic retraction: Possible involvement of CA1 neurons

et al. 2005

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“…It has also been demonstrated that the most severe stress-induced impairment occurred during proestrus, the estrus phase in which estrogen levels are highest. 32 In contrast, estrogen appears to facilitate spatial processing during stress 29 , indicating that estrogen's role in the stress response likely varies throughout the brain, enhancing function in some areas, while debilitating others.…”

Section: Estrogen Influences On Non-pfc Functions During Stressmentioning

confidence: 99%

Estrogen mediates sex differences in stress-induced prefrontal cortex dysfunction

et al. 2003

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Many anxiety disorders, as well as major depressive disorder (MDD), are at least twice as prevalent in women as in men, but the neurobiological basis of this discrepancy has not been well studied. MDD is often precipitated by exposure to uncontrollable stress, and is frequently characterized by abnormal or disrupted prefrontal cortex (PFC) function. In animals, exposure to stress has been shown to cause PFC dysfunction, but sex differences in this effect have not been investigated. The present study tested male and female rats on a PFC-dependent working memory task after administration of FG7142, a benzodiazepine inverse agonist that activates stress systems in the brain. Female rats were impaired by lower doses than males during proestrus (high estrogen), but not during estrus (low estrogen). Similarly, ovariectomized females showed increased stress sensitivity only after estrogen replacement. These results suggest that estrogen amplifies the stress response in PFC, which may increase susceptibility to stress-related disorders.

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“…For example, female rats seem more resistant to stress than males in cognitive performance [5][6][7][8]. The sexually dimorphic behaviour during stress has been related to fundamental physiological differences between males and females.…”

Section: Introductionmentioning

confidence: 99%

Sex differences in skilled movement in response to restraint stress and recovery from stress

Jadavji

Metz

2008

Behavioural Brain Research

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Sex differences exist in skilled movement, and skilled motor performance is also influenced by stress. As shown for cognitive function, the effects of stress are usually characterized by considerable sexual dimorphism. The purpose of this study was to investigate sex differences in skilled motor function in response to stress. Male and female Long-Evans rats were trained and tested in skilled reaching and skilled walking tasks. Both groups of animals were then exposed to daily restraint stress for 15 days. Recovery from daily stress was assessed by comparing reaching performance at 10 min versus 60 min after restraint stress, and recovery from chronic stress was tested for 21 days after cessation of stress. Animals were tested daily in skilled reaching for the entire period. Observations showed that females performed significantly better than males during the stress period in terms of reaching success and number of attempts needed to grasp a food pellet. No difference between testing at 10 or 60 min after daily stress was found. Analysis of movement patterns and recovery from stress indicated that males and females use different strategies to overcome stress-induced motor disturbance. While male rats preferred to use original movement patterns, females tended to modify these patterns in order to increase reaching success. Modification of movement patterns in female rats was accompanied by a faster recovery in success rate after the cessation of stress. These results indicate sex differences in skilled reaching in response to stress, and in the recovery period after stress.

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Effects of chronic restraint stress and estradiol on open field activity, spatial memory, and monoaminergic neurotransmitters in ovariectomized rats

Cited by 209 publications

References 57 publications

Chronic stress enhances spatial memory in ovariectomized female rats despite CA3 dendritic retraction: Possible involvement of CA1 neurons

Chronic stress enhances spatial memory in ovariectomized female rats despite CA3 dendritic retraction: Possible involvement of CA1 neurons

Estrogen mediates sex differences in stress-induced prefrontal cortex dysfunction

Sex differences in skilled movement in response to restraint stress and recovery from stress

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