Effects of chronic polychlorinated biphenyls exposure on reproductive success of white-footed mice (peromyscus leucopus)

Linzey, Alicia V.

doi:10.1007/bf01055267

Cited by 39 publications

(29 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In these species, the reproductive system and developing embryos are adversely affected by both acute and chronic exposures. A dietary LOAEL of 10 ppm was reported for white-footed mice (Linzey 1987). Using Eq.…”

Section: Toxicity To Wildlifementioning

confidence: 99%

Toxicological Benchmarks for Wildlife

Sample¹

1993

View full text Add to dashboard Cite

Section: Toxicity To Wildlifementioning

confidence: 99%

Toxicological Benchmarks for Wildlife

Sample¹

1993

View full text Add to dashboard Cite

“…NOAELs for developmental toxicity in rodents could not be identified, as the LOAEL was the lowest dose tested. (42); for rats (29); for mink (45); for monkeys (63). bLOAEL (mg/kg)2A/day = LOAEL mg/kg x WAh (61).…”

Section: Effects On Estrous Cycle and Conceptionmentioning

confidence: 99%

“…bLOAEL (mg/kg)2A/day = LOAEL mg/kg x WAh (61). For mice W = 23 g (42); for rats W = 300 g (29); for mink W = 1 kg (45); for monkeys W = 10 kg.…”

Section: Effects On Estrous Cycle and Conceptionmentioning

confidence: 99%

See 1 more Smart Citation

Reproductive Toxicity of Commercial PCB Mixtures: LOAELs and NOAELs from Animal Studies

Golub¹,

Donald²,

Reyes³

1991

Environmental Health Perspectives

View full text Add to dashboard Cite

This paper reviews the developmental/reproductive toxicity ofcommercial polychlorinated biphenyl (PCB) mixtures in anhnals and reports on the "no-observable-adverse-effect levels" (NOAEI) and "lowest-observable-adverse-effect levels" (LOAELs) fromthese Identc nof the lwest effective doses for reproductive toxicity of PCB mixtures is diffiult becas avariety of roductive and _o effects have been reported in several species using different commercial mixtures. Factors to be considered include sensitiv of the end point, sensitivity of species, study quality, biological plausibility, and relevance to humans. End points affected at the lowest doses (sensitive end points) included postnatal groWth, dedopment, and functio Among species for whom seniiv end points have been evaluated, a LOAEL of0.25 mg/kg/day was identified for rodents on the basis ofdevelopmentl delas in growth and behavioral hfncon, and a LOEL of&MO mg/kday was identified for nonhuman at based on tal skin hyperpgmentation. NOELs were not identifiable for these sensitive end points because effects were reported at the lowest doses tested.

show abstract

“…In addition, they cannot reproduce ecologic conditions that influence exposure and uptake of these pollutants in the wild, such as biomagnification and bioaccumulation (McBee and Bickham, 1990). Laboratory studies, therefore, should be complimented by risk assessment studies in natural populations exposed to typical environmental contaminant mixtures and levels (Linzey, 1987;Propst et al, 1999). Ideally, such ecotoxicologic field studies should not only assay the immune response of wild animals, but also provide estimates of contaminant levels of soil and animal tissue.…”

Section: Introductionmentioning

confidence: 99%

Effects of Heavy Metals on Immunocompetence of White-Footed Mice (Peromyscus Leucopus)

Biser

Vogel

Berger

et al. 2004

Journal of Wildlife Diseases

View full text Add to dashboard Cite

Continued human population growth and industrialization result in increased contamination of wildlife habitats. Effects of such habitat deterioration on the well-being of natural populations are unclear. Exposure to contaminants may impair immunocompetence, thereby increasing disease susceptibility. The mammalian immune system is important in maintaining health and in its sensitivity to toxins. In our study conducted from May 1999 through May 2001, we examined assays of immunocompetence in the white-footed mouse (Peromyscus leucopus) that inhabited reference sites and sites significantly contaminated with mixtures of heavy metals. We estimated potential exposure and uptake of heavy metals by measuring the level of each contaminant in representative soil and tissue samples. Intraindividual variation across mice, but not sex, explained a large portion of the overall variance in immune response, and spleen weight was significantly affected by mouse age. We found no evidence that residence on contaminated sites had any effect on immunopathology and humoral immunity as measured in our study. We suggest that field and laboratory studies in ecotoxicology provide estimates of exposure to contaminants (i.e., tissue analyses) to establish a database suitable to clarify the dose-response relationship between contaminants and target systems.

show abstract

Effects of chronic polychlorinated biphenyls exposure on reproductive success of white-footed mice (peromyscus leucopus)

Cited by 39 publications

References 26 publications

Toxicological Benchmarks for Wildlife

Toxicological Benchmarks for Wildlife

Reproductive Toxicity of Commercial PCB Mixtures: LOAELs and NOAELs from Animal Studies

Effects of Heavy Metals on Immunocompetence of White-Footed Mice (Peromyscus Leucopus)

Contact Info

Product

Resources

About