Effects of chronic lithium pretreatment on apomorphine-induced penile erection

Dehpour, Ahmad Reza; Samini, Morteza; Sharifzadeh, Mohammad; Hasan-Mazandarani, H.

doi:10.1016/0306-3623(94)00276-s

Cited by 16 publications

(16 citation statements)

References 25 publications

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“…It is also suggested that duration of lithium treatment may be involved in alterations of wave latency. Our previous works have shown that lithium can affect the responses mediated by the second messengers of the phophoinositide pathway (Sharifzadeh et al 1996(Sharifzadeh et al & 1997Dehpour et al 1995). Some studies also demonstrated that aminoglycoside antibiotics are capable of altering membrane permeablities and that this effect is most pronounced if PIP2 were present in the bilayers (Au et al 1987).…”

Section: Discussionmentioning

confidence: 97%

Effects of Chronic Lithium on Ototoxicity Induced by Gentamicin and Amikacin in Guinea‐Pigs

Sharifzadeh

Abdollahi

Behrooz

et al. 1998

Pharmacology & Toxicology

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Abstract:The effects of chronic lithium co-therapy on the expression of gentamicin and amikacin ototoxicity were tested in guinea-pigs. Intramuscular injection of different doses of gentamicin (5, 10 mgikgiday) and amikacin (150, 300 mglkgi day) for three weeks, induced hearing loss consistent with the established pattern of aminoglycoside ototoxicity. Lithium salts remains one of the most widely used treatment for depressive illness. Administration of lithium chloride (600 mdl, 35 days) in drinking water changed auditory brainstem response in a time-dependent manner. Pretreatment of animals with lithium chloride after seven days induced significant alterations in wave latency and interval. The present study assesses the protective effects of chronic lithium on gentamicin-induced ototoxicity in guinea pig. The results suggest that duration of lithium administration may be involved in auditory brainstem response changes and the observations could be accounted for, at least partially, by lithium-and aminoglycosides-induced perturbations of the phosphoinositide cascade within the inner ear.

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Section: Discussionmentioning

confidence: 97%

Effects of Chronic Lithium on Ototoxicity Induced by Gentamicin and Amikacin in Guinea‐Pigs

Sharifzadeh

Abdollahi

Behrooz

et al. 1998

Pharmacology & Toxicology

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“…23 Likewise, Dehpour et al have shown that both sulpiride and haloperidol inhibit APOinduced penile erection in rats whereas the combination of two drugs showed a greater inhibitory effect. 30 Therefore, the involvement of different types of dopamine receptors in APO-induced penile erection and female sexual arousal function remains controversial and require further investigation.…”

Section: Discussionmentioning

confidence: 99%

Systemic administration of apomorphine improves the hemodynamic mechanism of clitoral and vaginal engorgement in the rabbit

et al. 2000

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Clitoral and vaginal engorgement during sexual stimulation depend in part on the increase of arterial in¯ow. It has been shown that apomorphine (APO), a non-selective dopamine receptor agonist, produces penile erection by activating dopaminergic receptors in the central nervous system. Our aim was to study whether systemic administration of APO improves the hemodynamic mechanism of clitoral and vaginal engorgement in the rabbit.Female New Zealand white rabbits (3.5 ± 4 kg, n 6) were anesthetized. To examine sexual arousal function, the vaginalaclitoral branch of the pelvic nerve was stimulated electrically and maximal increases in clitoral intracavernosal and vaginal wall blood¯ows and pressures were recorded. After this APO was injected intravenously in a dose ± response manner (0.05, 0.1, 0.2, 0.3 and 0.4 mgakg) and nerve stimulation was performed after each dose. Changes in nerve-stimulated increase of clitoral intracavernosal and vaginal blood¯ows and pressures after APO was compared to those recorded before APO.Electrical stimulation of the vaginalaclitoral branch of the pelvic nerve signi®cantly increased clitoral intracavernosal and vaginal wall blood¯ows in the rabbit. Intravenous administration of APO caused concentration dependent increase in nerve stimulation-induced peak clitoral intracavernosal and vaginal wall blood¯ows reaching to statistically signi®cant at the concentration of 0.1 and 0.2 mgakg. Inravenous administration of APO greater than 0.2 mgakg (0.3 and 0.4 mgakg) were less effective or produced adverse effects on clitoral intracavernosal and vaginal wall blood¯ows. Intravenous APO also tended to increase nerve-stimulated increase of clitoral intracavernosal and vaginal wall pressures, but the effect was not statistically signi®cant.In conclusion, our studies suggest that systemic administration of APO may improve clitoral and vaginal engorgement by increasing clitoral intracavernosal and vaginal wall arterial in¯ow.

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“…However, there is increasing evidence that lithium exerts its therapeutic action by interfering with polyphosphoinositide metabolism and prevention of inositol recycling by an uncompetitive inhibition of inositol monophosphatase (Nahorzki, Ragan and Challis, 1991). Our previous work has shown that chronic lithium can alter apomorphine-induced PE in rats (Dehpour et al, 1995).…”

Section: Introductionmentioning

confidence: 99%

Alterations of bromocriptine-induced penile erection by chronic lithium in rats

et al. 1996

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In the present study, the effects of chronic lithium pre-treatment (30 days) on penile erection (PE) induced by bromocriptine were investigated in rats. Intraperitoneal administration of the dopamine receptor agonist, bromocriptine (4-32 mg/kg) induced PE in a biphasic manner. The maximum response was obtained with 8 mg/kg of bromocriptine and the effect was decreased with increasing doses of the drug from 8 to 32 mg/kg. When animals were pre-treated with different doses of the D-1 dopamine receptor antagonist, SCH 23390, or the D-2 dopamine receptor antagonist, sulpiride, the PE response was decreased. The response induced by bromocriptine (4-32mg/kg) was reduced in animals pre-treated with chronic lithium. SCH 23390 did not produce a larger inhibitory effect on the bromocriptine response in animals pre-treated with chronic lithium, but the inhibitory effect of sulpiride was increased in this condition. It is concluded that chronic lithium treatment may alter the D-1/D-2 receptor activity and inhibit bromocriptine-induced PE.

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Effects of chronic lithium pretreatment on apomorphine-induced penile erection

Cited by 16 publications

References 25 publications

Effects of Chronic Lithium on Ototoxicity Induced by Gentamicin and Amikacin in Guinea‐Pigs

Effects of Chronic Lithium on Ototoxicity Induced by Gentamicin and Amikacin in Guinea‐Pigs

Systemic administration of apomorphine improves the hemodynamic mechanism of clitoral and vaginal engorgement in the rabbit

Alterations of bromocriptine-induced penile erection by chronic lithium in rats

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