Effects of chronic lithium, amitriptyline and mianserin on glucoregulation, corticosterone and energy balance in the rat

Storlien, Leonard H; Higson, F.M.; Gleeson, Robert M.; Smythe, George A.; Atrens, Dale M.

doi:10.1016/0091-3057(85)90494-0

Cited by 27 publications

(17 citation statements)

References 44 publications

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“…These observed responses may have implications with respect to mood changes during the course of bulimic behavior. As has been demonstrated with animal work, carbohydrate loading reduces levels of the stress hormone corticosterone (Storlien et al, 1985;Smythe et al, 1984), and it is possible that patients seek this effect by consuming large quantities of carbohydrate. Alternatively, the fall in plasma noradrenalin and rise and fall in plasma cortisol may be associated with the development of a biphasic mood state culminating in depression which patients may attempt to alleviate by consuming more carbohydrate.…”

Section: Resultsmentioning

confidence: 95%

A proposed model of bulimic behavior: Effect on plasma insulin, noradrenalin, and cortisol levels

Russell

Storlien

Beumont

1987

Int. J. Eat. Disord.

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The purpose of this single case study of a bulimic patient was to replicate and incorporate certain elements of bulimic behavior, namely fasting, carbohydrate loading, vomiting, and binge eating, into the glucose tolerance test in order to observe the effects of these modifications on plasma insulin, noradrenalin, and cortisol. The most striking finding was that of potentiation of insulin secretion in response to a glucose load most marked after the subject had engaged in binging and vomiting. The results support the hypothesis that engagement in bulimic behaviors induces higher plasma insulin levels and that this precipitates a behavioral vicious cycle with associated mood changes. Other applications of this experimental model are discussed.

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Section: Resultsmentioning

confidence: 95%

A proposed model of bulimic behavior: Effect on plasma insulin, noradrenalin, and cortisol levels

Russell

Storlien

Beumont

1987

Int. J. Eat. Disord.

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“…Supplementation of saccharin to AMT-containing water reportedly improves water intake. 39 Hence, we performed two experiments; one was comparison between distilled water with and without AMT, and the other was comparison between saccharin (2%)-containing water with and without AMT. In the former experiments, AMT in drinking water was administered for 7 or 10 days to minimize the effects on physical health caused by dehydration.…”

Section: Tricyclic Antidepressant-induced Activity Change In Transgenmentioning

confidence: 99%

Mice with neuron-specific accumulation of mitochondrial DNA mutations show mood disorder-like phenotypes

et al. 2006

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There is no established genetic model of bipolar disorder or major depression, which hampers research of these mood disorders. Although mood disorders are multifactorial diseases, they are sometimes manifested by one of pleiotropic effects of a single major gene defect. We focused on chronic progressive external ophthalmoplegia (CPEO), patients with which sometimes have comorbid mood disorders. Chronic progressive external ophthalmoplegia is a mitochondrial disease, which is accompanied by accumulation of mitochondrial DNA (mtDNA) deletions caused by mutations in nuclear-encoded genes such as POLG (mtDNA polymerase). We generated transgenic mice, in which mutant POLG was expressed in a neuron-specific manner. The mice showed forebrain-specific defects of mtDNA and had altered monoaminergic functions in the brain. The mutant mice exhibited characteristic behavioral phenotypes, a distorted day-night rhythm and a robust periodic activity pattern associated with estrous cycle. These abnormal behaviors resembling mood disorder were worsened by tricyclic antidepressant treatment and improved by lithium, a mood stabilizer. We also observed antidepressant-induced mania-like behavior and long-lasting irregularity of activity in some mutant animals. Our data suggest that accumulation of mtDNA defects in brain caused mood disorder-like mental symptoms with similar treatment responses to bipolar disorder. These findings are compatible with mitochondrial dysfunction hypothesis of bipolar disorder.

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“…In lean animals, ciclazindol, an NA uptake inhibitor, has been shown to increase oxygen consumption in acute stud ies [21], and also to prevent the gain in body fat of cafeteria-overfed rats [22], while mian serin and also amitriptyline have been re ported to reduce weight gain and lower the metabolic efficiency [24], In man, controlled studies on the effect of antidepressants on weight gain are scarce, controversial, and most reports are anecdo tal and often involve the description of a sin gle case. For example, the report that ami triptyline causes carbohydrate craving and weight gains in humans [18] conflicts with other reports that it causes anorexia and weight loss [25].…”

Section: Discussionmentioning

confidence: 99%

“…The compo sition of the stock diet (g/kg) was as follows: 180 g protein. 24 g fat, 570 g carbohydrate, 36 g crude fibre, 30g vitamin mixture, 50g mineral mixture, UOg moisture content, and 14.2 MJ metabolisable energy (ME) per kg diet.…”

Section: Animalsmentioning

confidence: 99%

Screening of Drugs for Thermogenic Anti-Obesity Properties: Antidepressants

Dulloo¹,

Miller²

1987

Ann Nutr Metab

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Twelve antidepressant drugs, currently in clinical use, were screened for thermogenic properties on the basis of their ability to stimulate the activity of the sympathetic nervous system via an inhibitory effect on noradrenaline reuptake into the sympathetic neurons. Drug screening was carried out on mice made obese by hypothalamic lesioning using monosodium glutamate. Preliminary experiments, based on changes in body weight and food intake in response to increased doses of the drugs, indicate that most of the twelve antidepressants possess thermogenic potential. In particular, butriptyline, protriptyline and nortriptyline were most effective in causing marked losses in body weight without altering the food intake of the mice. The potent anti-obesity thermogenic properties of these three antidepressants were confirmed during a 10-week energy balance study involving measurements of energy expenditure over the entire period by the comparative carcass method, as well as by measurement of 24 h oxygen consumption. These studies indicate that the methodology employed in the preliminary screening is valid for identifying drugs with thermogenic potential, and demonstrate that many antidepressants currently in clinical use have marked thermogenic properties, and could therefore influence the nutritional status of patients under drug therapy.Introduction

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Effects of chronic lithium, amitriptyline and mianserin on glucoregulation, corticosterone and energy balance in the rat

Cited by 27 publications

References 44 publications

A proposed model of bulimic behavior: Effect on plasma insulin, noradrenalin, and cortisol levels

A proposed model of bulimic behavior: Effect on plasma insulin, noradrenalin, and cortisol levels

Mice with neuron-specific accumulation of mitochondrial DNA mutations show mood disorder-like phenotypes

Screening of Drugs for Thermogenic Anti-Obesity Properties: Antidepressants

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