Abstract:Hypercapnia and subsequent respiratory acidosis are serious complications in many patients with respiratory disorders. The acute response to hypercapnia is buffering of H
+
by hemoglobin and cellular proteins but this effect is limited. The chronic response is renal compensation that increases HCO
3
−
reabsorption, and stimulates urinary excretion of titratable acids (TA) and NH
4
+
. However, the main effective path… Show more
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