Effects of chronic HBV infection on lipid metabolism in non-alcoholic fatty liver disease: A lipidomic analysis

Han, Li; Xu, Qing-Yang; Xie, Yang; Luo, Jizhuang; Cao, Hongyan; Pan, Qin

doi:10.1016/j.aohep.2021.100316

Cited by 14 publications

(10 citation statements)

References 37 publications

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“…Venous blood samples were collected after at least 8 h of fasting and stored at −80°C for future measurements of free fatty acid. Detections of DHA, EPA, and AA were performed in a commercial company (BiotechPack ANALYTICAL, Beijing, China) using ultra-performance liquid chromatography-mass spectrometry methods according to previous reports ( 16 , 17 ). In brief, the stored serum samples were thawed at 4°C, and 50 mg of the samples were homogenized with 100 μL distilled water.…”

Section: Methodsmentioning

confidence: 99%

Association between the ratio of serum eicosapentaenoic acid to arachidonic acid and risk of coronary artery disease in young Chinese patients

Liu

Sun²,

Wen³

et al. 2022

Front. Nutr.

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ObjectiveLong-chain (LC) omega-3 PUFAs, including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), may play an anti-inflammatory effect and decrease the risk of coronary artery disease (CAD). In contrast, omega-6 PUFA, mainly arachidonic acid (AA), has pro-inflammatory and pro-aggregatory effects, which may increase the risk of CAD. This study evaluated the associations between EPA, DHA, AA, and their ratios (EPA/AA and DHA/AA) with the risk of CAD in young Chinese patients.MethodsA total of 182 young patients with CAD and 143 age-matched controls were included. Traditional cardiovascular risk factors were recorded. Serum EPA, DHA and AA were measured by ultra-performance liquid chromatography-mass spectrometry.ResultsThe level of AA was significantly higher, while the level of EPA was lower in the CAD group than that in the control group. There was no significant difference in DHA level in the two groups. Both the ratios of EPA/AA and DHA/AA were lower in the CAD group than that in the control. Multivariate logistic regression analysis showed that higher serum AA level was associated with the increased risk of CAD, while EPA was a protective factor for CAD. There was no significant association between DHA level and the risk of CAD. Although both higher ratios of EPA/AA [per tertile increment, adjusted odds ratios (ORs) (OR) 0.356, 95% confidence intervals (CI) 0.247–0.513] and DHA/AA (adjusted OR = 0.465, 95%CI = 0.332–0.653) were associated with a lower risk of CAD in young patients. Receiver operating characteristic (ROC) curve analysis showed that compared with AA, the diagnostic value was increased in EPA/AA, but not in DHA/AA.ConclusionEPA, but not DHA may play a protective role in CAD, while AA may be associated with the increased risk of CAD in young Chinese patients. The ratio of EPA/AA can increase the predictive value for diagnosing CAD than EPA or AA alone.

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Section: Methodsmentioning

confidence: 99%

Association between the ratio of serum eicosapentaenoic acid to arachidonic acid and risk of coronary artery disease in young Chinese patients

Liu

Sun²,

Wen³

et al. 2022

Front. Nutr.

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“…HBsAg-positive patients had decreased serum cholesterol and triglyceride levels and a decreased prevalence of hyperlipemia[ 27 , 33 , 34 ]. Our study revealed a lower levels of hepatoxic lipids in serum from NAFLD-HBV patients than in those with only NAFLD[ 35 ]. The natural course of HBV infection may play a role in changes in lipid metabolism, especially in elderly patients[ 36 ].…”

Section: Epidemiology Of Steatosis In Chbmentioning

confidence: 99%

Chronic hepatitis B infection with concomitant hepatic steatosis: Current evidence and opinion

Shi¹,

Yang²,

Fan³

2021

WJG

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With the increasing incidence of obesity and metabolic syndrome worldwide, concomitant nonalcoholic fatty liver disease (NAFLD) in patients with chronic hepatitis B (CHB) has become highly prevalent. The risk of dual etiologies, outcome, and mechanism of CHB with concomitant NAFLD have not been fully characterized. In this review, we assessed the overlapping prevalence of metabolic disorders and CHB, assessed the risk of advanced fibrosis/hepatocellular carcinoma in CHB patients concomitant with NAFLD, and discussed the remaining clinical issues to be addressed in the outcome of such patients. We also explored the possible roles of hepatitis B virus in the development of steatosis and discussed difficultiesof histological evaluation. For CHB patients, it is important to address concomitant NAFLD through lifestyle management and disease screening to achieve better prognoses. The assessment of progressive changes and novel therapies for CHB patients concomitant with NAFLD deserve further research.

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“…Interestingly, the downregulation of LPC 18:0 and LPE O-18:1 seen in both COV and COV/CA patients (Supplemental Figure 1A) correlated with the inflammatory profile of these latter (Figure 3). Of note, low levels of LPC 18:0 and LPE O-18:1 have also been reported in the serum from chronic HBV patients (39,40).…”

Section: Activation State Of Circulating Immune Cell Subsets In Covid...mentioning

confidence: 88%

Immunometabolic interference between cancer and COVID-19

et al. 2023

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Even though cancer patients are generally considered more susceptible to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, the mechanisms driving their predisposition to severe forms of coronavirus disease 2019 (COVID-19) have not yet been deciphered. Since metabolic disorders are associated with homeostatic frailty, which increases the risk of infection and cancer, we asked whether we could identify immunometabolic pathways intersecting with cancer and SARS-CoV-2 infection. Thanks to a combined flow cytometry and multiomics approach, here we show that the immunometabolic traits of COVID-19 cancer patients encompass alterations in the frequency and activation status of circulating myeloid and lymphoid subsets, and that these changes are associated with i) depletion of tryptophan and its related neuromediator tryptamine, ii) accumulation of immunosuppressive tryptophan metabolites (i.e., kynurenines), and iii) low nicotinamide adenine dinucleotide (NAD+) availability. This metabolic imbalance is accompanied by altered expression of inflammatory cytokines in peripheral blood mononuclear cells (PBMCs), with a distinctive downregulation of IL-6 and upregulation of IFNγ mRNA expression levels. Altogether, our findings indicate that cancer not only attenuates the inflammatory state in COVID-19 patients but also contributes to weakening their precarious metabolic state by interfering with NAD+-dependent immune homeostasis.

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Effects of chronic HBV infection on lipid metabolism in non-alcoholic fatty liver disease: A lipidomic analysis

Cited by 14 publications

References 37 publications

Association between the ratio of serum eicosapentaenoic acid to arachidonic acid and risk of coronary artery disease in young Chinese patients

Association between the ratio of serum eicosapentaenoic acid to arachidonic acid and risk of coronary artery disease in young Chinese patients

Chronic hepatitis B infection with concomitant hepatic steatosis: Current evidence and opinion

Immunometabolic interference between cancer and COVID-19

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