Effects of chronic exposure to benzalkonium chloride in Oncorhynchus mykiss : cholinergic neurotoxicity, oxidative stress, peroxidative damage and genotoxicity

Antunes, Sara C.; Nunes, Bruno; Rodrigues, Sara; Nunes, Ricardo Gomes dos Santos; Fernandes, J. C.; Correia, Alberto Teodorico

doi:10.1016/j.etap.2016.04.016

Cited by 39 publications

(21 citation statements)

References 47 publications

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“…Pavlaki et al [19] performed a study in which the DNA damage in Palaemon varians, Acartia tonsa, and Solea senegalensis exposed to different levels of Cd was evaluated, and controls ranged from 23.9% in A. tonsa to 31.7% DNA damage in P. varians (Zoea I). Additionally, almost similar values were found by Antunes et al [34], exposing Oncorhynchus mykiss to benzalkonium chloride, with a control damage of approximately 25%. The lowest DNA damage present in controls (14.3% tail DNA damage) was observed through the comet assay in 5 earthworm species (Amynthas diffringens, Aporrectodea caliginosa, Eisenia fetida, Dendrodrilus rubidus, and Microchaetus benhami) exposed to Cd [35].…”

Section: Resultssupporting

confidence: 84%

The comet assay in Folsomia candida: A suitable approach to assess genotoxicity in collembolans

Cardoso

Silva

Cruz

et al. 2017

Enviro Toxic and Chemistry

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The present study shows the comet assay technique being successfully applied for the first time to one of the most widely used soil organisms in standardized ecotoxicological tests, Folsomia candida, providing a step forward in assessing the genotoxicity induced by xenobiotics. Because collembolans have a high content of chitin, a new methodology was developed in which the heads of the collembolans were separated from the rest of the body, allowing the hemolymph to leak out. This procedure allows the cells to be released, and after lysis the genetic material is available for the comet assay. Among other key procedures, the use of 30 organisms (20- to 22-d-old adults) per replicate and the correct amount of cells with genetic material (translated as 10 μL of suspension) applied on the agarose gel were determinants for the success of the results obtained. The methodology was validated by exposing F. candida to a representative metallic element (cadmium) and a representative of organophosphates, the insecticide dimethoate, for a shorter time period of 10 d, compared with the 28 d for the International Organization for Standardization 11267 method. Within this method, the relatively low percentage of DNA damage (30%) observed in controls and the significant increase in terms of percentage of DNA damage for almost all the concentrations of dimethoate and Cd (reaching 52% and 56% of damage in the highest concentrations, respectively) confirmed the genotoxic effect of both compounds and validated this technique. The comet assay proved to be a sensitive technique to detect DNA strand breaks in collembolans' cells. Environ Toxicol Chem 2017;36:2514-2520. © 2017 SETAC.

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Section: Resultssupporting

confidence: 84%

The comet assay in Folsomia candida: A suitable approach to assess genotoxicity in collembolans

Cardoso

Silva

Cruz

et al. 2017

Enviro Toxic and Chemistry

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“…Moreover, a large number of studies have been conducted on ophthalmic toxicities such as corneal injury and irritation and intranasal damage of mucosal membranes [72]. Experimental results of a study conducted to analyze the effects of BAC in a dose-dependent manner showed neurites concentration decrease in corneal nerves and also induction of oxidative stress that leads to cholinergic neurotoxicity [73]. Recently, a study showed that the overproduction of ROS results in the destruction of caspase-8 expression, a result, the cell viability waned, when rat neural progenitor cells (NPCs) were exposed to a higher concentration of BAC [74].…”

Section: Benzalkonium Chloride and Its Cytotoxic Effectsmentioning

confidence: 99%

The Beast of Beauty: Environmental and Health Concerns of Toxic Components in Cosmetics

2020

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Cosmetic products are used in large quantities across the world. An increasing number of chemical compounds are being added to the formulation of cosmetic products as additives, fragrances, preservatives, stabilizers, surfactants, dye and shine to potentiate their quality, property and shelf life. Owing to their widespread use, active residues of cosmetic products are continuously introduced into the environment in several ways. Many of these chemicals are bioactive and are characterized by potential bioaccumulation ability and environmental persistence, thus exerting a major risk to humans and the health of ecosystems. Hence, the indiscriminate consumption of cosmetics may present a looming issue with significant adverse impacts on public health. This review intends to spotlight a current overview of toxic ingredients used in formulating cosmetics such as parabens, triclosan, benzalkonium chloride, 1,4-dioxane, plastic microbeads, formaldehyde, diazolidinyl urea, imidazolidinyl urea, sunscreen elements (organic and inorganic UV filters) and trace metals. Specific focus is given to illustrate the biological risks of these substances on human health and aquatic system in terms of genotoxicity, cytotoxicity, neurotoxicity mutagenicity, and estrogenicity. In addition to conclusive remarks, future directions are also suggested.

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“…Similarly, to other classes of food additives, preservatives must meet criteria for their use, since they are chemicals and may cause adverse health effects (Akintonwa et al, 2007). Recent toxicological studies indicate that certain concentrations of synthetic preservatives and their continuous use may be potentially mutagenic and/or genotoxic (Di Sotto et al, 2014;Antunes et al, 2016;Mellado-Garcia et al, 2017). Research is being conducted to find natural compounds with antimicrobial and antioxidant activity, which may be new alternatives to replace the commonly used synthetic preservatives or to make associations between them, thus reducing their amount in foods and their possible health risks (Ramalho and Jorge, 2006).…”

Section: Preservativesmentioning

confidence: 99%

Food additives and their health effects: A review on preservative sodium benzoate

Linke¹,

Casagrande²,

Cardoso³

2018

Afr. J. Biotechnol.

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Food additives are widely used by the food industry to increase the product shelf life and/or attribute as well as enhance certain characteristics of particular foods, which are often lost during processing. With the advent of modern life, more and more additives have been employed by the food industry. Despite their wide use, they are substances that may cause adverse reactions like any other drug. This study aimed to contextualize through a review of the literature, the scientific evidence on the risks entailed by the consumption of food additives, special regards to sodium benzoate. This additive is a sodium salt, which is commonly used as a chemical preservative in foods, and it is found mainly in industrialized drinks/beverages. Sodium benzoate is considered safe by major regulatory agencies, but there is still controversy over its effects on human health.

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Effects of chronic exposure to benzalkonium chloride in Oncorhynchus mykiss : cholinergic neurotoxicity, oxidative stress, peroxidative damage and genotoxicity

Cited by 39 publications

References 47 publications

The comet assay in Folsomia candida: A suitable approach to assess genotoxicity in collembolans

The comet assay in Folsomia candida: A suitable approach to assess genotoxicity in collembolans

The Beast of Beauty: Environmental and Health Concerns of Toxic Components in Cosmetics

Food additives and their health effects: A review on preservative sodium benzoate

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