Effects of chronic exposure of 2,4-dichlorophenol on the antioxidant system in liver of freshwater fish Carassius auratus

Zhang, Jingfei; Shen, Hua; Wang, Xiaorong; Wu, Jichun; Xue, Yingang

doi:10.1016/j.chemosphere.2003.10.048

Cited by 350 publications

(163 citation statements)

References 30 publications

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“…In general GPx activity decreased in high TiO2NP and combined exposures. This suggests that the increase in ROS production can lead to reduced activity of certain antioxidant enzymes (Livingstone, 2003;Zhang et al, 2004). Previous studies on interactions between these antioxidant enzymes reported that CAT plays a minor role in H2O2 metabolism when H2O2 is produced at low rates, but a larger role when H2O2 production is enhanced (Barata et al, 2005;Jones et al, 1981).…”

Section: Discussionmentioning

confidence: 99%

The impact of TiO2 nanoparticles on uptake and toxicity of benzo(a)pyrene in the blue mussel (Mytilus edulis)

Farkas

Bergum

Nilsen

et al. 2015

Science of The Total Environment

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Nanoparticles are emerging contaminants of concern. Knowledge on their environmental impacts is scarce, especially on their interactive effects with other contaminants. In this study we investigated effects of titanium dioxide nanoparticles (TiO2NP) on the blue mussel (Mytilus edulis) and determined their influence on the bioavailability and toxicity of benzo(a)pyrene (B(a)P), a carcinogenic polyaromatic hydrocarbon (PAH). Blue mussels were exposed to either TiO2NP (0.2 and 2.0 mg L -1 ) or B(a)P (20 µg L -1 ) and to the respective combinations of these two compounds. Aqueous contaminant concentrations, the uptake of Ti and B(a)P into mussel soft tissue, effects on oxidative stress and chromosomal damage were analyzed. The uncoated TiO2NP agglomerated rapidly in the seawater. The presence of TiO2NP significantly reduced the bioavailability of B(a)P, shown by lowered B(a)P concentrations in exposure tanks and in mussel tissue. The activities of antioxidant enzymes superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) were impacted by the various exposures regimes, indicating oxidative stress in the contaminant exposure groups. While SOD activity was increased only in the 0.2TiO2NP exposure group, CAT activity was enhanced in both combined exposure groups.The GPx activity was increased only in the groups exposed to the two single compounds. In hemocytes, increased chromosomal damage was detected in mussels exposed to the single compounds, which was further increased after exposure to the combination of compounds. In this study we show that the presence of TiO2NP in the exposure system reduced B(a)P uptake in blue mussels. However, since most biomarker responses did not decrease despite lower B(a)P uptake in combined exposures, the results suggest that TiO2NP can act as additional stressor, or potentially alters B(a)P toxicity by activation.

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Section: Discussionmentioning

confidence: 99%

The impact of TiO2 nanoparticles on uptake and toxicity of benzo(a)pyrene in the blue mussel (Mytilus edulis)

Farkas

Bergum

Nilsen

et al. 2015

Science of The Total Environment

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“…Usually an induction of hepatic SOD activities was observed when exposed to organic pollutant (Palace et al, 1996), however, the excess production of superoxide radicals by themselves or after their transformation to H 2 O 2 cause an oxidation of the cysteine in the enzyme and deactivate SOD (Dimitrova et al, 1994). Decreases of hepatic SOD activity were also found in fish exposed to 2, 4-Dichlorophenol (Zhang et al, 2004).…”

Section: Comparison Of the Susceptivity To Oxidative Damage Between Lmentioning

confidence: 99%

Effects of hexachlorobenzene on antioxidant status of liver and brain of common carp (Cyprinus carpio)

2006

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“…45 During present investigation, among the tissues studied, depletion in GSH was found to be highest in gills than liver and kidney and thus resulted in cell degeneration. 57 Similar decrease in liver & gills of Cyprinus carpio 58 & Carassius auratus 53 have also been reported on exposure to pesticide. Present observations are in concurrence with the findings of workers 46 studied effect of propiconazole on Oncorhynchus mykiss.…”

Section: Reduced Glutathione (Gsh)mentioning

confidence: 76%

“…53 It directly acts a scavenger of oxyradical and also as an antioxidant enzyme substrate. 46 Apparently GSH is important in protecting against deleterious effects of the cell exposed to ROS by reacting with them to form glutathione disulphide (GSSG).…”

Section: Reduced Glutathione (Gsh)mentioning

confidence: 99%

Oxidative Stress Response in Liver, Kidney and Gills of Ctenopharyngodon Idellus (Cuvier & Valenciennes) Exposed To Chlorpyrifos

Kaur

2017

MOJBM

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Study on the chronic effects of an organophosphate, chlorpyrifos inducing oxidative stress in freshwater culturable carp, Ctenopharyngodon idellus has been made on exposure to sub-lethal concentration (1.4µg/L and 2.44µg/L) of the pesticide for 15, 30 and 60 days. Antioxidants viz. catalase (CAT), superoxide dismutase (SOD), reduced glutathione (GSH), glutathione-s-transferase (GST) and lipid peroxidation (LPO) in the liver, kidney and gills of the fish were analyzed. Studies revealed that the enhanced productions of reactive oxygen species (ROS) lead to oxidative damage to lipids & proteins, and inhibit antioxidant defence system of fish. The activity of LPO has followed an increasing trend and a decline in the activity of CAT, SOD and GSH at both the concentrations throughout the experiment. However, no definite trend in the activity of GST has been observed. Prolonged exposure to chlorpyrifos enhanced ROS formation, finally resulted in oxidative damage to cell and inhibited antioxidant capacities in the fish tissues.

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Effects of chronic exposure of 2,4-dichlorophenol on the antioxidant system in liver of freshwater fish Carassius auratus

Cited by 350 publications

References 30 publications

The impact of TiO2 nanoparticles on uptake and toxicity of benzo(a)pyrene in the blue mussel (Mytilus edulis)

The impact of TiO2 nanoparticles on uptake and toxicity of benzo(a)pyrene in the blue mussel (Mytilus edulis)

Effects of hexachlorobenzene on antioxidant status of liver and brain of common carp (Cyprinus carpio)

Oxidative Stress Response in Liver, Kidney and Gills of Ctenopharyngodon Idellus (Cuvier & Valenciennes) Exposed To Chlorpyrifos

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