Effects of chronic cocaine, morphine and methamphetamine on the mobility, immobility and stereotyped behaviors in crayfish

Imeh-Nathaniel, Adebobola; Rincon, Natalia; Orfanakos, Vasiliki Bessie; Brechtel, Leanne; Wormack, Leah; Richardson, Erika; Huber, Robert; Nathaniel, Thomas I.

doi:10.1016/j.bbr.2017.05.069

Cited by 33 publications

(15 citation statements)

References 48 publications

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“…There was no static posture following the high dose amphetamine injection, but walking leg tremors, grooming, and perimeter exploration were observed. Low dose of cocaine injections produced enhanced rearing, antennae movement, and exploration of the corner of the experimental aquarium (Imeh-Nathaniel et al, 2017 ). A prior study investigated the effect of cocaine on specific locomotive traits (Nathaniel et al, 2012a ), where intrapericardial injections of repeated doses of cocaine over the course of 3 days, decreased dose dependent lingering, increased speed of locomotion, distance traveled, and mobility, as well as increased immobility.…”

Section: Drugs Of Abuse Augment Stereotypic Behaviors (Unconditioned mentioning

confidence: 99%

The Sensitivity of the Crayfish Reward System to Mammalian Drugs of Abuse

et al. 2017

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The idea that addiction occurs when the brain is not able to differentiate whether specific reward circuits were triggered by adaptive natural rewards or falsely activated by addictive drugs exist in several models of drug addiction. The suitability of crayfish (Orconectes rusticus) for drug addiction research arises from developmental variation of growth, life span, reproduction, behavior and some quantitative traits, especially among isogenic mates reared in the same environment. This broad spectrum of traits makes it easier to analyze the effect of mammalian drugs of abuse in shaping behavioral phenotype. Moreover, the broad behavioral repertoire allows the investigation of self-reinforcing circuitries involving appetitive and exploratory motor behavior, while the step-wise alteration of the phenotype by metamorphosis allows accurate longitudinal analysis of different behavioral states. This paper reviews a series of recent experimental findings that evidence the suitability of crayfish as an invertebrate model system for the study of drug addiction. Results from these studies reveal that unconditioned exposure to mammalian drugs of abuse produces a variety of stereotyped behaviors. Moreover, if presented in the context of novelty, drugs directly stimulate exploration and appetitive motor patterns along with molecular processes for drug conditioned reward. Findings from these studies indicate the existence of drug sensitive circuitry in crayfish that facilitates exploratory behavior and appetitive motor patterns via increased incentive salience of environmental stimuli or by increasing exploratory motor patterns. This work demonstrates the potential of crayfish as a model system for research into the neural mechanisms of addiction, by contributing an evolutionary, comparative context to our understanding of natural reward as an important life-sustaining process.

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Section: Drugs Of Abuse Augment Stereotypic Behaviors (Unconditioned mentioning

confidence: 99%

The Sensitivity of the Crayfish Reward System to Mammalian Drugs of Abuse

et al. 2017

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“…Stereotypies have been associated with dysfunction of the prefronto-corticobasal ganglia circuits or cortico-striatal-thalamo-cortical pathways (Unal, Beverley, Willuhn, & Steiner, 2009). In animal models, the appearance of stereotypies after consuming levodopa, amphetamine, and cocaine suggests an association with overstimulation of dopaminergic systems (Canales & Graybiel, 2000; Imeh-Nathaniel et al, 2017). Dopamine-transporter knockout mice showed prominent motor stereotypies, supporting the association between stereotypies and dopamine neurotransmission (Cinque et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Prevalence and determinants of motor stereotypies in autism spectrum disorder: A systematic review and meta-analysis

Melo

Ruano

Jorge

et al. 2019

Autism

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Stereotypies are frequently reported in people with autism spectrum disorder (ASD) but remain one of the less explained phenomena. We aimed to describe, through a systematic review and a meta-analysis, the prevalence of motor stereotypies in ASD and study the factors that influence this prevalence. Our literature search included MEDLINE, Scopus, and PsycINFO databases. Quality and risk of bias were assessed. Thirty-seven studies were included and the median prevalence of motor stereotypies in ASD was 51.8%, ranging from 21.9% to 97.5%. The most frequent determinants associated with a higher number of stereotypies in ASD were a younger age, lower intelligence quotient, and a greater severity of ASD. Moreover, gender did not seem to influence the prevalence of stereotypies. Meta-analytic analysis showed that lower IQ and autism diagnosis (independent of IQ) are associated with a higher prevalence of motor stereotypies (odds ratio = 2.5 and 4.7, respectively). Limitations of the reviewed literature include the use of convenience samples, with small sizes and heterogeneous inclusion criteria, and the predominance of high-functioning autism individuals.

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“…In the context of an increasing number of studies reporting behavioural effects in nonmurine animals induced by drugs 41–43 , we hope the present work may contribute to broaden the advantages to use the motility of aquatic animal models.…”

Section: Discussionmentioning

confidence: 91%

The effect of hydrophobic gases on the nervous system of Daphnia magna

Robledo-Sánchez

Ruiz‐Suárez

2021

Preprint

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Hundreds of hydrophobic substances: alkanes, alcohols, benzodiacepines, barbiturates, ethers and even gases, can induce General Anaesthesia (GA) in mammal animals. Moreover, it has been suggested that the primary site of action of such agents is on the spinal cord. Here, we investigate a scenario that is in double measure important to understand the mechanisms behind GA: its induction under water in invertebrate animals. We evaluate the capacity of xenon, nitrous oxide and krypton to suppress harmful sensations, provoked by intense light, in the crustacean D. magna. Due to the hydrophobic characteristics of those gases, we designed a special chamber to force them to dissolve in water at pressures up to to 50 atmospheres, whereas at the same time measure in real time the motility of the animals. Surprisingly, the aquatic animals are immobilized with xenon and nitrous oxide. Under this condition, they do not respond to a noxious stimulus. Our results are crucial to understand the action of inert gases in GA and the role of the spinal cord.

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Effects of chronic cocaine, morphine and methamphetamine on the mobility, immobility and stereotyped behaviors in crayfish

Cited by 33 publications

References 48 publications

The Sensitivity of the Crayfish Reward System to Mammalian Drugs of Abuse

The Sensitivity of the Crayfish Reward System to Mammalian Drugs of Abuse

Prevalence and determinants of motor stereotypies in autism spectrum disorder: A systematic review and meta-analysis

The effect of hydrophobic gases on the nervous system of Daphnia magna

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