Effects of Chronic Boron Exposure on Semen Profile

Korkmaz, Mehmet; Yenigün, Mehmet; Bakırdere, Sezgin; Ataman, O. Yavuz; Keskin, Sıddık; Müezzinoğlu, Talha; Lekili, Murat

doi:10.1007/s12011-010-8928-2

Cited by 27 publications

(13 citation statements)

References 23 publications

(31 reference statements)

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“…In our study group, boron exposure was found to be 6.1±3.0 mg/day. In our previous studies using the same part of Turkey, daily boron exposure in men were found to be 6·77 mg/day (SE, 0·47) [15] and 6.48 mg/day (SE, 0.12) [16]. The result obtained in the present study is very close to the previous findings as stated above.…”

Section: Discussionsupporting

confidence: 91%

Prevalence of Prostate Cancer in High Boron-Exposed Population: A Community-Based Study

Müezzinoğlu

Korkmaz

Neşe

et al. 2011

Biol Trace Elem Res

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We investigated the possible relationship between boron exposure and prostate cancer (PCa) for men living and being employed at boron mines in villages with rich boron minerals. Out of 456 men studied, 159 were from villages with rich boron sources and boron levels in drinking water of >1 mg L(-1) and these men formed the study group, while 63 from villages with rich boron sources and boron levels in drinking water of <1 mg L(-1) were enrolled into control group 1. A further 234 subjects from other villages with no boron mines were considered as control group 2. Prostate specific antigen (PSA) levels could be obtained from a total of 423 men. Urinary boron concentration as an indicator of boron exposure in 63 subjects, prostatic volumes by transrectal ultrasonography in 39 subjects, and prostatic biopsies in 36 subjects were obtained for study and control groups. The daily boron exposure was calculated according to urinary boron levels. Although there was no significant difference among the groups in terms of total PSA levels, the number of subjects with tPSA ≥2.5 and tPSA ≥10.0 ng dL(-1) prostatic volumes in men whose prostates were biopsied (p < 0.012) was significantly lower in the study group as compared with those in the control group 2. These results suggested that high exposure to boron might have an implication within the prostatic cellular processes related to hyperplasia and carcinogenesis, even though we did not find a statistically significant association between PCa and boron exposure.

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Section: Discussionsupporting

confidence: 91%

Prevalence of Prostate Cancer in High Boron-Exposed Population: A Community-Based Study

Müezzinoğlu

Korkmaz

Neşe

et al. 2011

Biol Trace Elem Res

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“…As for boron, there is no clear evidence that occupational exposure impairs sperm concentration, motility, morphology, or DNA integrity (95)(96)(97).…”

Section: Effects Of Occupational Exposure To Metals On Reproductive Pmentioning

confidence: 99%

Reproductive Toxicity of Metals in Men

Pizent¹,

Tariba²,

Živković³

2012

Archives of Industrial Hygiene and Toxicology

106

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A combination of genetic, environmental and lifestyle factors contributes to adverse effects on the reproductive health in men. Metals are pervasive in food, water, air, tobacco smoke, and alcoholic beverages. Experimental studies suggest that many metals have adverse effects on the male reproductive function. However, information about reproductive effects of human exposure to metals is scarce and/or inconsistent. This review summarises the information from epidemiological studies of the effects of metal exposure on reproductive function in men. Factors capable of affecting these relationships were identifi ed and discussed. A particular attention is given to the studies considering infl uence of concomitant exposure to various metals. These studies have generally confi rmed that even moderate-to low-level exposure to lead affects certain reproductive parameters, and that exposure to cadmium affects the prostate function and serum testosterone levels. Adverse effects of mercury, manganese, chromium and arsenic on semen quality and altered serum hormone are less well documented. There is no clear evidence that boron exposure may impair reproductive health in men. Only a few studies have investigated reproductive effects of concomitant exposure to several metals and controlled for potential confounders. Future studies should consider the contribution of combined exposure to various metals and/or other factors that may infl uence individual susceptibility to reproductive health impairment in men. KEY WORDS: human semen quality, metals, metalloids, metal interactions, sex hormonesPizent A, et al.

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“…In addition, many researchers (Ç öl et al 2000;Korkmaz et al 2011;Türkez et al 2012) indicated that chronic boron exposure does not have important toxic effects because there is no established clear increase of disease among the people in the region. It is known that boron compounds belong to the second class of toxicological danger (WHO 1998a).…”

Section: Discussionmentioning

confidence: 99%

Invisible Face of Boron Pollution in Fluvial Ecosystem: The Level in the Tissues of Sentinel and Nectonic Organisms

Arslan

2013

AMBIO

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Turkey is the largest producer of borate products in the world. Among four largest boron mines in Turkey two of them are located in basins of Orhaneli and Emet Streams. In this study, boron levels in abiotic (watersediment) and some biotic elements (sentinel organisms; Asellus aquaticus, Gammarus pulex, Chironomus tentans, Limnodrilus hoffmeisteri and nektonic organism; Squalius cii) of Orhaneli and Emet Streams were investigated and their ranks among the food chain were demonstrated. Since Orhaneli and Emet Streams confluence to form Mustafakemalpaşa Brook which feeds Uluabat Lake which is one of the most important Ramsar fields of the world, Boron levels in those two streams have importance in terms of both continuances of aquatic systems. Present study results have shown that boron levels in water of both streams are much higher (vary between 8.64 and 16.73 mg L -1 ) than not only Turkish Standard but also limits determined by WHO, US EPA, and NAS. Boron levels determined in sediments of two streams vary between 18.05 and 36.7 mg kg -1 . The highest boron level in the biotic elements was determined in liver of Squalius cii (34.64 mg kg -1 ), it is followed by Limnodrilus hoffmeisteri (2.84 mg kg -1 ), Chironomus tentans (2.11 mg kg -1 ), and Gammarus pulex (1.98 mg kg -1 ).

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Effects of Chronic Boron Exposure on Semen Profile

Cited by 27 publications

References 23 publications

Prevalence of Prostate Cancer in High Boron-Exposed Population: A Community-Based Study

Prevalence of Prostate Cancer in High Boron-Exposed Population: A Community-Based Study

Reproductive Toxicity of Metals in Men

Invisible Face of Boron Pollution in Fluvial Ecosystem: The Level in the Tissues of Sentinel and Nectonic Organisms

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