Effects of chronic and acute methylphenidate hydrochloride (ritalin) administration on locomotor activity, ultrasonic vocalizations, and neuromotor development in 3‐ to 11‐day‐old CD‐1 mouse pups

Penner, Marsha R.; McFadyen, Melanie P.; Carrey, Normand; Brown, Richard E.

doi:10.1002/dev.1047

Cited by 17 publications

(8 citation statements)

References 62 publications

(71 reference statements)

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“…Previous studies reported a dose‐related locomotor‐increasing characteristic of chronic MP exposure (Griggs et al, ; Kuczenski & Segal, ; Penner, McFadyen, Carrey, & Brown, ; Yang, Swann, & Dafny, ). Indeed, similar to our previous reports following uninterrupted 13‐week daily MP exposure (Martin et al, ; Robison, Michaelos, et al, ) and 13‐week daily MP exposure with weekend abstinence periods (Carias et al, ), chronic MP consumption increased locomotor activity in this study.…”

Section: Discussionmentioning

confidence: 93%

Brief and extended abstinence from chronic oral methylphenidate treatment produces reversible behavioral and physiological effects

Kalinowski

Connor

Somanesan

et al. 2019

Developmental Psychobiology

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Methylphenidate (MP) is a commonly prescribed psychostimulant to individuals with Attention Deficit Hyperactivity Disorder, and is often used illicitly among healthy individuals with intermittent breaks to coincide with breaks from school. This study examined how intermittent abstinence periods impact the physiological and behavioral effects of chronic oral MP self‐administration in rats, and whether these effects persist following prolonged abstinence from the drug. Rats were treated orally with water, low‐dose (LD), or high‐dose (HD) MP, beginning at PND 28. This daily access continued for three consecutive weeks followed by a 1‐week abstinence; after three repeats of this cycle, there was a 5‐week abstinence period. Throughout the study, we examined body weight, food intake, locomotor activity, and anxiety‐ and depressive‐like behaviors. During the treatment phase, HD MP decreased body weight, food intake, and depressive‐ and anxiety‐like behaviors, while it increased locomotor activity. During intermittent abstinence, the effects of MP on locomotor activity were eliminated. During prolonged abstinence, most of the effects of HD MP were ameliorated to control levels, with the exception of weight loss and anxiolytic effects. These findings suggest that intermittent exposure to chronic MP causes physiological and behavioral effects that are mostly reversible following prolonged abstinence.

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Section: Discussionmentioning

confidence: 93%

Brief and extended abstinence from chronic oral methylphenidate treatment produces reversible behavioral and physiological effects

Kalinowski

Connor

Somanesan

et al. 2019

Developmental Psychobiology

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“…Spontaneous locomotion, isolationinduced ultrasonic vocalizations, and neuromotor coordination were tested in CD-1 mice administered MPH daily from 3 to 11 days of age. Concurrent testing found an increase in locomotor activity in MPH-treated mice (as expected for this stimulant), but no differences in emission of ultrasonic vocalizations or neuromotor behavior (Penner, McFadyen, Carrey & Brown, 2001). These results suggest that while short-term MPH treatment does increase spontaneous locomotion, it has no immediate effects on anxiety or neuromotor development during the first 11 days of life in CD-1 mice.…”

Section: Discussionmentioning

confidence: 92%

Subchronic methylphenidate administration has no effect on locomotion, emotional behavior, or water maze learning in prepubertal mice

McFadyen

Brown

Carrey³

2002

Developmental Psychobiology

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Methylphenidate hydrochloride (Ritalin, MPH) is frequently prescribed as a treatment for children with attention deficit hyperactivity disorder (ADHD), yet little research has been conducted to determine its potential long-term neurobehavioral effects. We assessed the effects of subchronic MPH administration (2.5, 5, 10, 20, 40, or 80 mg/kg) on male CD-1 mice treated from 26 to 32 days of age. When tested at 33 days of age in the open field and elevated plus maze, there were no significant differences in spontaneous locomotion, exploration, or fear- and anxiety-related behaviors. Testing from 34 to 37 days of age in a water maze task revealed no significant effects of any dose of MPH on learning in this simple paradigm. While it is difficult to extrapolate directly from these results to clinical effects in humans, our results indicate that preexposure of mice to MPH late in the postnatal developmental period does not appear to alter later behavior. We are currently conducting additional studies to further probe the potential effects of MPH administration during development and to examine various contributing factors including stage of development, duration of MPH administration, complexity of the task used to assess behavioral changes, and type of cognitive process being analyzed (attention, nonspatial working memory, etc.).

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“…For instance, methylphenidate increased locomotor activity in mice (Penner et al, 2001). A single dose of methylphenidate improved motor coordination in children with developmental coordination disorder and ADHD (Bart et al, 2013), perhaps compensating for impaired integrity of the white matter connecting the thalamus with primary motor cortex and hippocampus (Xia et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

The effects of methylphenidate on resting-state striatal, thalamic and global functional connectivity in healthy adults

Farr

Zhang

et al. 2014

Int. J. Neuropsychopharm.

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By blocking dopamine and norepinephrine transporters, methylphenidate affects cognitive performance and regional brain activation in healthy individuals as well as those with neuropsychiatric disorders. Resting-state connectivity evaluates the functional integrity of a network of brain regions. Here, we examined how methylphenidate effects resting-state functional connectivity of the dorsal striatum and thalamus, areas each with dense dopaminergic and noradrenergic innervations, as well as global cerebral connectivity. We administered a single, oral dose (45 mg) to 24 healthy adults and compared resting-state connectivity to 24 demographically matched adults who did not receive any medication. The results showed that methylphenidate alters seed-based and global connectivity between the thalamus/dorsal striatum with primary motor cortex, amygdala/hippocampus and frontal executive areas (p<0.05, corrected). Specifically, while methylphenidate at this dosage enhances connectivity to the motor cortex and memory circuits, it dampens prefrontal cortical connectivity perhaps by increasing catecholaminergic signalling past the ‘optimal’ level. These findings advance our understanding of a critical aspect of the multifaceted effects of methylphenidate on brain functions. The results may also facilitate future studies of the aetiology and treatment of neurological and psychiatric disorders that implicate catecholaminergic dysfunction.

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Effects of chronic and acute methylphenidate hydrochloride (ritalin) administration on locomotor activity, ultrasonic vocalizations, and neuromotor development in 3‐ to 11‐day‐old CD‐1 mouse pups

Cited by 17 publications

References 62 publications

Brief and extended abstinence from chronic oral methylphenidate treatment produces reversible behavioral and physiological effects

Brief and extended abstinence from chronic oral methylphenidate treatment produces reversible behavioral and physiological effects

Subchronic methylphenidate administration has no effect on locomotion, emotional behavior, or water maze learning in prepubertal mice

The effects of methylphenidate on resting-state striatal, thalamic and global functional connectivity in healthy adults

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