Effects of chromium picolinate on vascular reactivity and cardiac ischemia-reperfusion injury in spontaneously hypertensive rats

Abebe, Worku; Liu, Jun Yao; Wimborne, Hereward; Mozaffari, Mahmood S.

doi:10.1016/s1734-1140(10)70324-8

Cited by 16 publications

(11 citation statements)

References 27 publications

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“…[811] The trivalent form of chromium (chromium picolinate) was found to be a better absorbed form of the ion. [12] It was shown to act via chromodulin, a chromium-binding oligopetide in the autoamplification of insulin signaling. [13] Other effects of chromium include better insulin binding, increased receptor number, internalization, and improved beta cell sensitivity.…”

Section: Discussionmentioning

confidence: 99%

“…[16] Chromium picolinate improved coronary flow and recovery of myocardial contractility and relaxation following ischemic reperfusion insult in a rat model. [12] In the female mink, a significant effect was observed with a supplementation of herring oil, chromium picolinate and acetylsalicylic acid;[17] paradoxically a combination of the three led to increased glucose levels, suggesting that adverse interactions may occur with a combination of dietary supplements. In contrast, humans with GDM had a positive effect with chromium supplementation.…”

Section: Discussionmentioning

confidence: 99%

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Serum chromium levels in gestational diabetes mellitus

Sundararaman

Sridhar

Sujatha

et al. 2012

Indian J Endocr Metab

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Objective:To measure serum chromium level in women with gestational diabetes mellitus (GDM) from Chennai, South India.Materials and Methods:Thirty women with gestational diabetes, 60 age matched controls. Inclusion criteria: Gestational age 22-28 weeks, age group 20-35 years.Exclusion Criteria:Gestational age beyond 28 weeks, malnutrition or presence of infection. Serum chromium was measured using inductive couple plasma emission spectrometer.Results:Serum chromium levels of women with GDM, 1.59+/-0.02 ng/ml (range: 0.16-4.0 ng/ml) were lower than in controls (4.58+/-0.62 ng/ml; range 0.82-5.33 ng/ml) (P < 0.001). However, there were no significant differences among cases and controls when subdivided by parity.Conclusions:Women with GDM from a South Indian city had lower levels of serum chromium compared to pregnant women without GDM. Studies may be done whether chromium supplementation is useful in this group of women.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Serum chromium levels in gestational diabetes mellitus

Sundararaman

Sridhar

Sujatha

et al. 2012

Indian J Endocr Metab

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“…By administering Cr, the negative impacts of HS may be alleviated through increasing insulin sensitivity. First, improving insulin sensitivity can enhance skin micro-circulation ( Serné et al, 1999 ; Forst et al, 2006 ) and Cr can facilitate vasodilation ( Abebe et al, 2010 ). Therefore, Cr may have an ability to facilitate radiant heat dissipation and thus etiologically alleviate HS.…”

Section: Introductionmentioning

confidence: 99%

Effects of chromium supplementation on physiology, feed intake, and insulin related metabolism in growing pigs subjected to heat stress

Liu

Cottrell

Wijesiriwardana

et al. 2017

Translational Animal Science

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Improving insulin sensitivity may reduce impacts of heat stress (HS) in pigs by facilitating heat dissipation. Chromium (Cr) has been reported to improve insulin sensitivity in pigs. Therefore, the aim of this experiment was to investigate whether Cr supplementation can mitigate HS in growing pigs. Thirty-six gilts were randomly assigned to 2 diets containing 0 (control) or 400 ppb Cr. After 14 d the supplemented pigs were allocated to either 8 d thermoneutral (20°C constant; TN) or cyclic HS (35°C, 0900 h to 1700 h) conditions and continued their respective diet (n = 9 per group). Growth performance was recorded during the 14-d supplementation period. The physiological responses to HS were monitored by measuring respiration rate, rectal temperature, blood gas chemistry, and feed intake during thermal exposure. Kinetics of plasma glucose, insulin and NEFA were studied by intravenous glucose tolerance test (IVGTT) on d 8 of thermal treatment. Results showed Cr alleviated the HS-increased rectal temperature (P < 0.05) and respiration rate (P < 0.01) at 1300 h and 1600 h during thermal exposure. However, Cr did not mitigate the reduction in average daily feed intake which was reduced by 35% during HS or the HS-induced respiratory alkalosis. Chromium tended to increase average daily gain (0.86 vs. 0.95 kg, P = 0.070) during the 14-d supplementation under TN conditions before thermal exposure, which might be associated with the potential of Cr in improving overall insulin sensitivity, as evidenced by a reduced insulin resistance index calculated by Homeostatic Model Assessment (HOMA-IR; 0.65 vs. 0.51, P = 0.013) and a tendency of reduced fasting plasma insulin concentration (1.97 vs. 1.67 μU/mL, P = 0.094). Heat stress decreased the acute insulin releasing rate (P = 0.012) and consequently slowed glucose clearance rate (P = 0.035) during IVGTT. Besides, HS enlarged the values of area under the curve of NEFA during IVGTT (P < 0.01), indicating a reduced lipid mobilization. In conclusion, HS reduced insulin response to IVGTT. Chromium supplementation exhibited a potential in improving insulin sensitivity and mitigating HS symptoms in growing pigs.

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“…Cr(pic)3 supplementation has the potential to reduce cellular oxidative stress (30,31), levels of proinflammatory cytokines (32)(33)(34), blood cholesterol and triglycerides in diabetes (26,32). Whereas Cr(pic)3 has been extensively investigated in relation to carbohydrate and lipid metabolism, there are only a few studies devoted to the effects of Cr (pic)3 on the cardiovascular system (36,37). No data are available concerning whether Cr(pic)3 could elicit cardioprotective effects in rats with infracted hearts.…”

Section: Introductionmentioning

confidence: 99%

Preventive Effects of Selenium Yeast, Chromium Picolinate, Zinc Sulfate and their Combination on Oxidative Stress, Inflammation, Impaired Angiogenesis and Atherogenesis in Myocardial Infarction in Rats

et al. 2014

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Purpose: Accumulating evidences suggest a critical role of trace metal dyshemostasis in oxidative stress and cardiac dysfunction after myocardial infarction (MI). This study investigated the cardioprotective effects of selenium yeast (Se), chromium picolinate Cr(pic)3, zinc sulfate (Zn) and their combination on isoproterenol (ISO)-induced MI. Methods: Rats were divided into six groups: normal control, ISO control, Se-pretreated (0.1 mg/kg), Cr(pic)3-pretreated (400 µg/kg), Zn-pretreated (30 mg/kg) and metal combination-pretreated groups. All metals were administered for 28 days and at the 27th day, MI was induced by subcutaneous injection of ISO (85 mg/kg) once for two consecutive days. Results: ISO control group showed hyperlipidemia, elevation of cardiac biomarkers and lipid peroxidation and increased immunostaining of p47 phox NADPH oxidase subunit in addition to decreased levels of glutathione (GSH), superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx). Cardiac levels of tumor necrosis factor-α (TNF-α) were increased, while vascular endothelial growth factor (VEGF, the major angiogenic factor) was decreased. Pretreatment with Se normalized the cardiac enzymes, lipid peroxidation, GSH, SOD, CAT, GPx, TNF-α and VEGF (P<0.001) and reduced the immunostaining of p47 phox subunit. However, Se failed to correct the dyslipidemia. Cr(pic)3 significantly improved lipid profile (P<0.001) and all other biochemical deviations except for VEGF. Zn, but to lesser extent, reduced the oxidative damage and TNF-α levels and improved both dyslipidemia and angiogenesis. Combination therapy exhibited less prominent protection compared to individual metals. Conclusion: Daily supplementation with trace metals is promising for improving myocardial performance via preventing oxidative damage, induction of angiogenesis, anti-inflammatory and/or anti-hyperlipidemic mechanisms.This article is open to POST-PUBLICATION REVIEW. Registered readers (see “For Readers”) may comment by clicking on ABSTRACT on the issue’s contents page.

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Effects of chromium picolinate on vascular reactivity and cardiac ischemia-reperfusion injury in spontaneously hypertensive rats

Cited by 16 publications

References 27 publications

Serum chromium levels in gestational diabetes mellitus

Serum chromium levels in gestational diabetes mellitus

Effects of chromium supplementation on physiology, feed intake, and insulin related metabolism in growing pigs subjected to heat stress

Preventive Effects of Selenium Yeast, Chromium Picolinate, Zinc Sulfate and their Combination on Oxidative Stress, Inflammation, Impaired Angiogenesis and Atherogenesis in Myocardial Infarction in Rats

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