Effects of Cholinoblockers on Acetylcholine Content in Rat Striatum in Neuroleptic-Induced Parkinsonism

Abstract

Correction of neuroleptic-induced parkinsonism in rats with two central cholinoblockers atropine and pentifine (acetylene aminoalcohol synthesized at Institute of Toxicology) were studied by measuring the content of acetylcholine in the striatum. The content of the transmitter secretion was estimated from the content of bound acetylcholine fraction in homogenates of the above-mentioned compartment of the brain. The results indicate that atropine and pentifine in doses equally effectively preventing catalepsy in rats had different effects on acetylcholine secretion in the striatum. Hence, cholinolytics with different pharmacological selective effects differently interact with central muscarine receptor subtypes.

Maternal caffeine exposure alters neuromotor development and hippocampus acetylcholinesterase activity in rat offspring

“…We can also suggest a possible alteration in the dopaminergic system, since acetylcholine and dopamine strongly interact and play an important role in motor control (Calabresi et al, 2006;Jensen et al, 2011). Decreased dopaminergic system activity has been shown to occur in parallel with cholinergic system hyperactivity, according to the classical clinical hypothesis (Dagaev et al, 2004). The release of ACh underlies the inhibitory control of the dopamine D2 receptors present in cholinergic interneurons; decreased dopaminergic activity leads to enhanced ACh release and consequently to over-stimulation of muscarinic receptors in the striatum (Alfaro et al, 2005;Threlfell et al, 2010).…”