Effects of chlorhexidine, NaF and SnF₂ on glucan formation by salivary and culture supernatant GTF adsorbed to hydroxyapatite

Abstract

– Chlorhexidine, NaF and SnF2 were tested for inhibitory activity against glucosyltrans‐ferase (GTF) which had been adsorbed to hydroxyapatite. The sources of GTF were culture supernatants of S. mutans grown in BHI or stimulated whole saliva supernatants. Chlorhexidine inhibited GTF activity from culture supernatants as well as from saliva. NaF and SnF2 had moderate effects.

The effect of different formulations of chlorhexidine in reducing levels of mutans streptococci in the oral cavity: A systematic review of the literature

“…It likewise inhibits the action of the glycosyltransferase enzyme, responsible for accumulation of bacteria on the dental surface, and has effects on sugar transport and acid production in oral bacteria. 13,[16][17][18] Chlorhexidine comes in the form of dentifrices (0.4%), solutions (0.12% and 0.2%), gels (1%), and varnishes (1%, 10%, 20%, and 35%). A number of studies have been designed to evaluate how different formulations of chlorhexidine decrease MS in the oral cavity.…”

Muntingia calabura L Leaves Extract Inhibits Glucosyltransferase Activity of Streptococcus mutans

“…Penggunaan klorheksidin glukonat 0,12% sebagai kontrol positif karena klorheksidin glukonat merupakan standar baku obat kumur. 20 Penggunaan klorheksidin glukonat ini sesuai dengan penelitian terdahulu, 21 untuk mengetahui kemampuan penghambatan klorheksidin glukonat terhadap aktivitas enzim GTF. Hasil dari penelitian ini menunjukkan bahwa tidak terdapat perbedaan yang bermakna antara kontrol positif dengan EDK 10%.…”

Chlorhexidine in Cleft Lip and Palate Patients with Multibracket Appliances

“…This impairs intercellular membrane transport and obstructs the adsorption to oral glycoproteins necessary for biofilm formation [43]. CHX inactivates the glucosyltransferase that is important for bacterial adhesion [45]. It also reduces the protein adsorption to the tooth surface necessary for pellicle formation [6].…”

“…Hierdurch wird zum einen der interzelluläre Membrantransport gestört und zum anderen die für die Biofilmbildung notwendige Adsorption an orale Glykoproteine behindert [43]. CHX inaktiviert die Glykosyltransferase, die für die Bakterienadhäsion wichtig ist [45]. Ferner wird die für die Pellikelbildung notwendige Proteinadsorption auf der Zahnoberfläche reduziert [6].…”