Effects of chlordiazepoxide hydrochloride on discrimination responses and sleep cycles in cats

Schallek, William; Kuehn, Alfred; Kovacs, J. L.

doi:10.1016/0028-3908(72)90058-5

Cited by 21 publications

(4 citation statements)

References 14 publications

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“…Regarding diazepam, SWS values were not significantly different from control. Similar negative results on SWS were also observed in the cat atter the administration of several benzodiazepine derivatives (Lanoir and Killam, 1968;Schallek, Kuehn, and Kovacs, 1972;Gogerty, 1973). However, aflcer the combined administration of non-effective doses of GHB and diazepam, significantly higher amounts of SWS2 at the expense of W were obtained.…”

Section: Discussionsupporting

confidence: 78%

The effects of the combined administration of gamma-hydroxybutyrate and diazepam on sleep parameters in the rat

Monti

Altier

D'Angelo

1979

J. Neural Transmission

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The actions of diazepam and gamma-hydroxybutyrate (GHB) were assessed on the sleep-wakefulness cycle of male Wistar rats. One and 2 mg/kg diazepam and 12.5 mg/kg GHB had no effects on the sleep variables. After 25 mg/kg GHB, slow wave sleep (SWS2) was significantly increased. Following the combined administration of non-effective doses of GHB and diazepam, significantly higher amounts of SWS2 at the expense of wakefulness were obtained. The injection of a subconvulsant dose of bicuculline (2.5 mg/kg) prior to treatments which significantly increased SWS2 prevented this effect to show up. It is suggested that the actions of GHB and diazepam on the sleep-awake cycle are related to the same neurotransmitter system.

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Section: Discussionsupporting

confidence: 78%

The effects of the combined administration of gamma-hydroxybutyrate and diazepam on sleep parameters in the rat

Monti

Altier

D'Angelo

1979

J. Neural Transmission

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“…Similar be havioral observations following BZ administra tion have been made by several investigators (4,25,30,32,36). K ott and Winters (18) de scribed after various doses of DZ a dose/timerelated continuum of sedation, activation and hypnosis.…”

Section: Discussionsupporting

confidence: 58%

“…Furthermore, the average percentage of sleep time rapidly increased from saline controls to a dose of 0.9 mg/kg of DZ and then decreased for doses of 1.2 and 1.5 mg/kg. Several studies reported similiar effects on SWS with CZ and medazepam (11,12), whereas others obtained a decrease in SWS with CZ (14,32). Lanoir and Killam (20) demonstrated increased wakeful ness during the first 6 h after DZ administered in doses ranging from 0.25 to 2.0 mg/kg.…”

Section: Discussionmentioning

confidence: 99%

Effects of Diazepam on Sleep, Temperature, 5-Hydroxyindoleacetic and Homovanillic Acids in Cisternal Cerebrospinal Fluid of Cats

Griauzde¹,

Chen²,

Radulovački³

1979

Pharmacology

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The effects of diazepam (DZ) (0.3–1.5 mg/kg, i.p.) on sleep, cisternal cerebrospinal fluid (CSF) concentrations of 5-hydroxyindoleacetic acid (5-HIAA) and homovanillic acid (HVA), and rectal temperature of cats were examined. The results showed that administration of DZ produced a significant increase (p = 0.02) in slow-wave sleep (SWS) with a peak occurring at a dose of 0.9 mg/kg. Further increase in doses of DZ decreased SWS. DZ administration produced no change in paradoxical sleep, rectal temperature, 5-HIAA or HVA CSF levels. Lack of correlation between various doses of DZ, and 5-HIAA or HVA concentrations in the presence of an increased percentage of SWS suggests a possible mode of DZ action mediated through a mechanism independent of monoamines. Usually monoamines are associated with normal sleep.

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“…In animals, an increase in wakefulness or a clear excitatory effect are often seen with benzodiazepines in acute administration, or initially in long-term treat ment (Schallek et al, 1972a(Schallek et al, , 1973. Their hypnogenic effect in man could be related to a depression of the waking system, proportionally more marked with respect to the depression of the synchronizing system of slow-wave sleep.…”

Section: Discussionmentioning

confidence: 99%

EEG Sleep Studies of Insomniacs under Flunitrazepam Treatment

Gaillard¹,

Tissot²

1975

Int Pharmacopsychiatry

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This study investigates the effect of flunitrazepam, a new benzodiazepine, on the sleep of insomniac patients under chronic treatment. Polygraphic recordings have shown that this drug decreases not only the activity of the wakefulness system, but also the activity of the synchronizing system of slow-wave sleep. The subjective feeling of improved and sounder sleep seems to be related to a decrease of wakefulness pressure as well as to a decrease of body motoricity, but not with the modification of sleep stages themselves. Flunitrazepam appears to possess some regulatory properties on REM sleep, since this stage is enhanced in patients with an initial low amount of REM sleep and decreased in those having a higher initial REM sleep. Flunitrazepam possesses potent and useful hypnogenic properties in man but does not induce physiological sleep.

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Effects of chlordiazepoxide hydrochloride on discrimination responses and sleep cycles in cats

Cited by 21 publications

References 14 publications

The effects of the combined administration of gamma-hydroxybutyrate and diazepam on sleep parameters in the rat

The effects of the combined administration of gamma-hydroxybutyrate and diazepam on sleep parameters in the rat

Effects of Diazepam on Sleep, Temperature, 5-Hydroxyindoleacetic and Homovanillic Acids in Cisternal Cerebrospinal Fluid of Cats

EEG Sleep Studies of Insomniacs under Flunitrazepam Treatment

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