Effects of chitooligosaccharide supplementation on growth performance, nutrient digestibility, blood characteristics and immune responses after lipopolysaccharide challenge in weanling pigs

Chen, Y.J.; Kim, I.H.; Cho, J.H.; Yoo, J.S.; Wang, Y.; Huang, Y. S.; Kim, H.J.; Shin, S.O.

doi:10.1016/j.livsci.2009.02.006

Cited by 42 publications

(27 citation statements)

References 16 publications

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“…In the current study, apparent digestibility of major nutrients except fat was increased when pigs were offered increasing levels of dietary chitosan. This result was in agreement with that of previous studies which indicated that dietary supplementation of chitosan was effective in increasing apparent total tract digestibility of nutrients (DM, CP, gross energy, crude fat, N, Ca, and P) in pigs and other farm animals (Lim et al, 2006;Liu et al, 2008;Chen et al, 2009). On the contrary, non-positive effects on nutrients' digestibility were reported by some other authors Pettersson, 1994, 1996;O'Shea et al, 2011).…”

Section: Discussionsupporting

confidence: 93%

Effects of chitosan supplementation on the growth performance, nutrient digestibility, and digestive enzyme activity in weaned pigs

Xu¹,

Shi²,

Yan³

et al. 2014

CZECH J ANIM SCI

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ABSTRACT:The present experiments were conducted to investigate the effects of dietary chitosan on growth performance, nutrient digestibility, and digestive enzyme activities in weaned pigs. A total of 180 weaned pigs (35 days of age, 11.56 ± 1.61 kg of body weight (BW)) were selected and assigned randomly to 5 treatments containing 0, 100, 500, 1000, and 2000 mg chitosan per kg feed, respectively. Each treatment involved six replicate pens and six pigs per pen. On days 14 and 28, all pigs were weighed and six from each treatment (one from each replicate pen) were killed, and the contents of the stomach, jejunum, and rectum were collected and used for determining nutrient digestibility and digestive enzyme activity. The results showed that supplementation of chitosan improved quadratically average daily gain (ADG) (P < 0.05). Moreover, dietary chitosan quadratically (P < 0.05) increased apparent digestibility of crude protein (CP) on days 14 and 28, and quadratically increased apparent digestibility of dry matter (DM) on day 14 and of Ca and P on day 28, whereas decreased (P < 0.05) apparent digestibility of ether extract in comparison with the control diet. In addition, dietary chitosan quadratically increased (P = 0.062) amylase activity of proximal jejunum and decreased (P < 0.05) lipase activity of distal jejunum compared with the control. These data indicated that diets supplemented with increasing levels of chitosan (0, 100, 500, 1000, and 2000 mg chitosan per kg) quadratically improved ADG of weaned pigs. The growth-promoting action was achieved probably by improved digestibility of major nutrients (DM, CP, Ca, and P) and increased amylase activity of jejunum.

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Section: Discussionsupporting

confidence: 93%

Effects of chitosan supplementation on the growth performance, nutrient digestibility, and digestive enzyme activity in weaned pigs

Xu¹,

Shi²,

Yan³

et al. 2014

CZECH J ANIM SCI

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“…A reduction in the corticosterone and ACTH levels was observed in restraint stress-associated mice supplemented with Bifidobacterium animalis (Sudo et al, 2004) or Lactobacillus farciminis (Eutamene and Bueno, 2007) compared with nonsupplemented restraint stress-associated mice. Similarly, feeding a diet supplemented with chito-oligosaccharide prebiotic to lipopolysaccharidechallenged weaning piglets lowered the concentration of cortisol compared with nonsupplemented piglets (Chen et al, 2009). In the current study, the serum level of T 4 was similar in supplemented groups compared with TN.…”

Section: Discussionmentioning

confidence: 99%

Alleviation of cyclic heat stress in broilers by dietary supplementation of mannan-oligosaccharide and Lactobacillus-based probiotic: Dynamics of cortisol, thyroid hormones, cholesterol, C-reactive protein, and humoral immunity

et al. 2010

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Heat stress (HS), one of the major problems of tropical and subtropical countries, adversely affects the production performance of poultry. Keeping this in view, the present study was designed to investigate some of the biological markers of HS in broilers as modulated by dietary supplementation of mannan-oligosaccharide (MOS) and a Lactobacillus-based probiotic (LBP), either alone or in combination. Two hundred fifty 1-d-old-chicks were randomly divided into 5 groups. From d 22, the birds were either kept at the thermoneutral zone (TN) or exposed to HS to the conclusion of study, d 42. Birds were fed either a corn-based basal diet (TN and HS groups) or the same diet supplemented with 0.5% MOS (HS-MOS group), 0.1% LBP (HS-LBP group), or their combination. Birds were immunized against Newcastle disease virus on d 4 (intraocular; live attenuated) and d 20 (drinking water; live attenuated) and infectious bursal disease virus on d 8 (intraocular; live intermediate strain) and d 24 (drinking water; live attenuated). Birds were killed on d 42 to collect serum for determination of cortisol, thyroid hormones, cholesterol, C-reactive protein, and postvaccinal antibody titers. Results revealed that dietary supplementations decreased (P < 0.05) the serum cortisol and cholesterol concentrations and increased (P < 0.05) thyroxine concentration compared with the HS group without affecting triiodothyronine concentration. The percentage of the C-reactive protein-positive birds was higher (P < 0.05) in the HS group compared with the TN group. Dietary supplementations improved humoral immunity against Newcastle disease virus and infectious bursal disease virus during HS. In conclusion, dietary supplementation of either MOS or LBP alone or in combination can reduce some of the detrimental effects of HS in broilers.

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“…Studies of the effect of chitosan on piglet growth attributed the influence on immune ability, morphology of the intestine, and microflora function [7, 8]. The results were variable and the dosages used in the studies were large (100 mg/kg–5 g/kg).…”

Section: Introductionmentioning

confidence: 99%

Low Dosage of Chitosan Supplementation Improves Intestinal Permeability and Impairs Barrier Function in Mice

Guan

Wang²,

Peng

et al. 2016

BioMed Research International

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The purpose of this study was to explore relationships between low dose dietary supplementation with chitosan (COS) and body weight, feed intake, intestinal barrier function, and permeability in mice. Twenty mice were randomly assigned to receive an unadulterated control diet (control group) or a dietary supplementation with 30 mg/kg dose of chitosan (COS group) for two weeks. Whilst no significant differences were found between the conditions for body weight or food and water intake, mice in the COS group had an increased serum D-lactate content (P < 0.05) and a decreased jejunal diamine oxidase (DAO) activity (P < 0.05). Furthermore, mice in COS group displayed a reduced expression of occludin and ZO-1 (P < 0.05) and a reduced expression of occludin in the ileum (P < 0.05). The conclusion drawn from these findings showed that although 30 mg/kg COS-supplemented diet had no effect on body weight or feed intake in mice, this dosage may compromise intestinal barrier function and permeability. This research will contribute to the guidance on COS supplements.

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Effects of chitooligosaccharide supplementation on growth performance, nutrient digestibility, blood characteristics and immune responses after lipopolysaccharide challenge in weanling pigs

Cited by 42 publications

References 16 publications

Effects of chitosan supplementation on the growth performance, nutrient digestibility, and digestive enzyme activity in weaned pigs

Effects of chitosan supplementation on the growth performance, nutrient digestibility, and digestive enzyme activity in weaned pigs

Alleviation of cyclic heat stress in broilers by dietary supplementation of mannan-oligosaccharide and Lactobacillus-based probiotic: Dynamics of cortisol, thyroid hormones, cholesterol, C-reactive protein, and humoral immunity

Low Dosage of Chitosan Supplementation Improves Intestinal Permeability and Impairs Barrier Function in Mice

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