Effects of Chicory on Serum Uric Acid, Renal Function, and GLUT9 Expression in Hyperuricaemic Rats with Renal Injury and <i>In Vitro</i> Verification with Cells

Jin, Yong-Nan; Lin, Zhijian; Zhang, Bing; Bai, Ya Na

doi:10.1155/2018/1764212

Cited by 16 publications

(17 citation statements)

References 29 publications

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“…C. intybus L., commonly known as chicory, is often used as a cholagogic and diuretic agent, which conforms to the therapeutic principle of hyperuricemia and gout in Chinese traditional medicine. Our previous studies demonstrated the promising effect of chicory on lowering serum urate levels [22,23,24,25], and other reports have also shown the anti-inflammatory effect of chicory extract [26]. Combining the traditional use of and modern pharmacological research on chicory, we posited that chicory may be a safe antigout agent that can address both the symptoms and root causes of gout.…”

Section: Discussionmentioning

confidence: 86%

“…Moreover, the Food and Drug Administration (FDA) has classified chicory extract as “generally regarded as safe” and listed it in the “Everything Added to Food in the United States” category [21]. In previous studies, we found that chicory could significantly decrease serum uric acid, and its anti-hyperuricemia effect may be associated with both the inhibition of urate formation by suppressing xanthine oxidase activity and the promotion of urate excretion by regulating transporter expression [22,23,24,25]. The literature also shows that chicory possesses anti-inflammatory activity [26].…”

Section: Introductionmentioning

confidence: 99%

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Cichorium intybus L. Extract Suppresses Experimental Gout by Inhibiting the NF-κB and NLRP3 Signaling Pathways

Wang

Lin

Zhang

et al. 2019

IJMS

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Background: The production and maturation of interleukin (IL)-1β, regulated by the NF-κB and NLRP3 signaling pathways, lie at the core of gout. This study aimed to evaluate the antigout effect of Cichorium intybus L. (also known as chicory) in vivo and in vitro. Methods: A gout animal model was established with monosodium urate (MSU) crystal injections. Rats were orally administered with chicory extract or colchicine. Levels of ankle edema, inflammatory activity, and IL-1β release were observed. Several essential targets of the NF-κB and NLRP3 signaling pathways were detected. Primary macrophages were isolated to verify the antigout mechanism of chicory extract as well as chicoric acid in vitro. Results: Improvements of swelling degree, inflammatory activity, and histopathological lesion in MSU-injected ankles were observed in the treatment with chicory extract. Further, the chicory extract significantly decreased IL-1β release by suppressing the NF-κB and NLRP3 signaling pathways in gout rats. Similar to the in vivo results, IL-1β release was also inhibited by chicory extract and chicoric acid, a specific effective compound in chicory, through the NF-κB and NLRP3 signaling pathways. Conclusion: This study suggests that chicory extract and chicoric acid may be used as promising therapeutic agents against gout by inhibiting the NF-κB and NLRP3 signaling pathways.

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Section: Discussionmentioning

confidence: 86%

Section: Introductionmentioning

confidence: 99%

Cichorium intybus L. Extract Suppresses Experimental Gout by Inhibiting the NF-κB and NLRP3 Signaling Pathways

Wang

Lin

Zhang

et al. 2019

IJMS

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“…The nephroprotective effect of the extract was confirmed in the human kidney cell line through inhibition of GLUT-9 expression, an important transporter of uric acid in kidneys. Chicory extract could also decrease renal damage in an experimental model of chronic renal failure; however, the administered doses of the extract (6.6 and 13.2 g/ kg) were dramatically higher than benzbromarone (20 mg/kg) as the standard drug (Jin et al, 2018).…”

Section: Chicory (Cichorium Intybus L)mentioning

confidence: 93%

An Evaluation of Traditional Persian Medicine for the Management of SARS-CoV-2

Bahramsoltani

Rahimi

2020

Front. Pharmacol.

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A new coronavirus causing severe acute respiratory syndrome (SARS-CoV-2) has emerged and with it, a global investigation of new antiviral treatments and supportive care for organ failure due to this life-threatening viral infection. Traditional Persian Medicine (TPM) is one of the most ancient medical doctrines mostly known with the manuscripts of Avicenna and Rhazes. In this paper, we first introduce a series of medicinal plants that would potentially be beneficial in treating SARS-CoV-2 infection according to TPM textbooks. Then, we review medicinal plants based on the pharmacological studies obtained from electronic databases and discuss their mechanism of action in SARS-CoV-2 infection. There are several medicinal plants in TPM with cardiotonic, kidney tonic, and pulmonary tonic activities, protecting the lung, heart, and kidney, the three main vulnerable organs in SARS-CoV-2 infection. Some medicinal plants can prevent “humor infection”, a situation described in TPM which has similar features to SARS-CoV-2 infection. Pharmacological evaluations are in line with the therapeutic activities of several plants mentioned in TPM, mostly through antiviral, cytoprotective, anti-inflammatory, antioxidant, and anti-apoptotic mechanisms. Amongst the primarily-introduced medicinal plants from TPM, rhubarb, licorice, garlic, saffron, galangal, and clove are the most studied plants and represent candidates for clinical studies. The antiviral compounds isolated from these plants provide novel molecular structures to design new semisynthetic antiviral agents. Future clinical studies in healthy volunteers as well as patients suffering from pulmonary infections are necessary to confirm the safety and efficacy of these plants as complementary and integrative interventions in SARS-CoV-2 infection.

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“…We focused our attention particularly on systematic reviews and meta-analysis, when possible, or on single in vitro, in vivo, and clinical trials studies, applying no time filters. Based on this data, specific and detailed tables were produced ( Table 4 and Supplementary Materials Table S1 [ 2 , 3 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , ...…”

Section: Methodsmentioning

confidence: 99%

Using Medicinal Plants in Valmalenco (Italian Alps): From Tradition to Scientific Approaches

et al. 2020

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This ethnobotanical survey was carried out in Caspoggio (Valmalenco, SO, Italy) with the purpose of investigating the traditional uses of medicinal plants. Moreover, a bibliographic research meant to validate or refute the uses, focusing on the potentially responsible compounds, was performed. Fifty-nine species, attributable to 30 families (Asteraceae, Pinaceae, Malvaceae, and Lamiaceae the most cited), were mentioned. Arnica montana, anti-inflammatory for traumas and musculoskeletal pains; Pinus mugo, expectorant; Malva sylvestris, anti-inflammatory and soothing; Achillea moschata, digestive. The compounds, responsible for the therapeutic activities, are often polyphenols and terpenoids: helenanin in A. montana, α-pinene, δ-3-carene, and limonene in P. mugo, gossypin and malvin in M. sylvestris, luteolin and apigenin in A. moschata. Scientific evidence for at least one of the traditional activities described was found for 50 species but only in 26 out of 196 works consulted, it is possible to make a comparison between investigated extracts and traditional preparations. This study is thus a stimulus to new phytochemical investigations, mimicking as much as possible the traditional preparations. This work is part of the European Interreg Italy-Switzerland B-ICE project, aimed at creating a management model for the ongoing climate change and searching for new sources of territory valorization as attractions for tourists.

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Effects of Chicory on Serum Uric Acid, Renal Function, and GLUT9 Expression in Hyperuricaemic Rats with Renal Injury and In Vitro Verification with Cells

Cited by 16 publications

References 29 publications

Cichorium intybus L. Extract Suppresses Experimental Gout by Inhibiting the NF-κB and NLRP3 Signaling Pathways

Cichorium intybus L. Extract Suppresses Experimental Gout by Inhibiting the NF-κB and NLRP3 Signaling Pathways

An Evaluation of Traditional Persian Medicine for the Management of SARS-CoV-2

Using Medicinal Plants in Valmalenco (Italian Alps): From Tradition to Scientific Approaches

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