Effects of chemotherapy on invasion and metastasis of oral cavity cancer in mice

Kawashiri, Shin‐ya; Kojima, Kazuhiko; Kumagai, Shinya; Nakagawa, Kiyomasa; Yamamoto, Etsuhide

doi:10.1002/hed.1109

Cited by 7 publications

(3 citation statements)

References 18 publications

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“…They were housed and maintained in laminar flow cabinets under pathogen-free conditions. Oral SCC cells (KOSC2, HSC2 and OSC19; 2.0×10 5 cells/25 µl of serum-free culture medium) were injected into the lateral tongue with a microsyringe with a 27-gauge needle as outlined in a previous study [36]. The mice were weighed twice a week and housed until 14 days after the injection.…”

Section: Methodsmentioning

confidence: 99%

Progression of Oral Squamous Cell Carcinoma Accompanied with Reduced E-Cadherin Expression but Not Cadherin Switch

et al. 2012

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The cadherin switch from E-cadherin to N-cadherin is considered as a hallmark of the epithelial-mesenchymal transition and progression of carcinomas. Although it enhances aggressive behaviors of adenocarcinoma cells, the significance and role of cadherin switch in squamous cell carcinomas (SCCs) are largely controversial. In the present study, we immunohistochemically examined expression of E-cadherin and N-cadherin in oral SCCs (n = 63) and its implications for the disease progression. The E-cadherin-positive carcinoma cells were rapidly decreased at the invasive front. The percentage of carcinoma cells stained E-cadherin at the cell membrane was reduced in parallel with tumor dedifferentiation (P<0.01) and enhanced invasion (P<0.01). In contrast, N-cadherin-positive cells were very limited and did not correlate with the clinicopathological parameters. Mouse tongue tumors xenotransplantated oral SCC cell lines expressing both cadherins in vitro reproduced the reduction of E-cadherin-positive carcinoma cells at the invasive front and the negligible expression of N-cadherin. These results demonstrate that the reduction of E-cadherin-mediated carcinoma cell-cell adhesion at the invasive front, but not the cadherin switch, is an important determinant for oral SCC progression, and suggest that the environments surrounding carcinoma cells largely affect the cadherin expression.

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Section: Methodsmentioning

confidence: 99%

Progression of Oral Squamous Cell Carcinoma Accompanied with Reduced E-Cadherin Expression but Not Cadherin Switch

et al. 2012

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“…9 Kawashiri et al established the cervical lymph node metastatic cell line of oral carcinoma, known as OSC219, in 2001. 10 Qiu et al 11 orthotopically transplanted lymph node metastatic specimens of human tongue carcinoma into the tongues of nude mice and observed lymph node metastasis in that animal system. The establishment of these cell lines and animal tumor model has contributed to both fundamental and clinical research on carcinogenesis, and led to important developments and advances in prognosis of human tongue carcinoma.…”

Section: Discussionmentioning

confidence: 98%

Establishment of an Orthotopic Transplantation Model of Tongue Carcinoma

Jin

Gergen²,

Yu³

2014

Journal of Craniofacial Surgery

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“…In this model with OSC-19 cell lines, metastasis to the cervical lymph node was markedly inhibited by cisplatin or peplomycin and the combination of neoadjuvant chemotherapy and tumor resection. 35 , 36 Another experimental model of invasion and metastasis was built by orthotopic transplantation of HSC-2, HSC-3, and HSC-3 cell lines into tongue of nude mice. 37 …”

Section: Immunocompromised Modelmentioning

confidence: 99%

Immunocompromised and immunocompetent mouse models for head and neck squamous cell carcinoma

Lei¹,

Ren²,

Wang³

et al. 2016

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Mouse models can closely mimic human oral squamous epithelial carcinogenesis, greatly expand the in vivo research possibilities, and play a critical role in the development of diagnosis, monitoring, and treatment of head and neck squamous cell carcinoma. With the development of the recent research on the contribution of immunity/inflammation to cancer initiation and progression, mouse models have been divided into two categories, namely, immunocompromised and immunocompetent mouse models. And thus, this paper will review these two kinds of models applied in head and neck squamous cell carcinoma to provide a platform to understand the complicated histological, molecular, and genetic changes of oral squamous epithelial tumorigenesis.

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Effects of chemotherapy on invasion and metastasis of oral cavity cancer in mice

Abstract: Chemotherapy is effective not only for tumor diminution but also for inhibiting invasion and metastasis. In light of these effects, administration of anticancer drugs may be clinically useful in this regard.

Cited by 7 publications

References 18 publications

Progression of Oral Squamous Cell Carcinoma Accompanied with Reduced E-Cadherin Expression but Not Cadherin Switch

Progression of Oral Squamous Cell Carcinoma Accompanied with Reduced E-Cadherin Expression but Not Cadherin Switch

Establishment of an Orthotopic Transplantation Model of Tongue Carcinoma

Immunocompromised and immunocompetent mouse models for head and neck squamous cell carcinoma

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