Effects of chemotherapeutic agents on male germ cells and possible ameliorating impact of antioxidants

Ghafouri‐Fard, Soudeh; Shoorei, Hamed; Abak, Atefe; Seify, Mohammad; Mohaqiq, Mahdi; Keshmir, Fatemeh; Taheri, Mohammad; Ayatollahi, Seyed Abdulmajid

doi:10.1016/j.biopha.2021.112040

Cited by 29 publications

(32 citation statements)

References 133 publications

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“…In addition to a potential long-term impact on spermatogenesis (and hence fertility) in men [418], there is evidence of an adverse impact on germ cell development and male-mediated teratogenicity from animal studies [419][420][421][422], although this has not been proven in humans [423][424][425].…”

Section: Cyclophosphamidementioning

confidence: 99%

British Society for Rheumatology guideline on prescribing drugs in pregnancy and breastfeeding: immunomodulatory anti-rheumatic drugs and corticosteroids

et al. 2022

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Section: Cyclophosphamidementioning

confidence: 99%

British Society for Rheumatology guideline on prescribing drugs in pregnancy and breastfeeding: immunomodulatory anti-rheumatic drugs and corticosteroids

et al. 2022

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“…Dilated blood sinusoid (BS) with rounded Kupffer cells (KC) having electron dense nucleus (N) is also noticed; (I&J) an intact nucleus (N) and cytoplasm possessing mitochondria (M), lysosomes (Ly), rough (RER) and smooth (SER) endoplasmic reticula in hepatocyte of MLT-treated rat. Also, blood sinusoid (BS) with well-structured Kupffer cell (KC), as well as space of Disse (D) is revealed; (K&L) improvement of most of the cellular organization of hepatocyte which appeared with nearly normal nucleus (N), mitochondria (M), lysosomes (Ly), rough (RER), and smooth (SER) endoplasmic reticula, in addition to intact Kupffer cell (KC) lined the blood sinusoid (BS) of MLT+TXL-treated rat DISCUSSION Chemotherapy is particularly efficacious at preventing the spread of cancer cells (Bray et al, 2018) and Taxol (TXL) is considered one of the highly effective drugs used in the world which acts as antimicrotubule agents and possesses two unique properties including its ability to attach to a distinct binding site on the microtubule polymer and the ability to polymerize tubulin without the aid of co-factors (Ghafouri-Fard, et al, 2021). Consequently, it is vastly utilized to treat a variety of malignancies including lung, thyroid, prostate, breast, ovarian, head, and neck, in addition to Kaposi sarcoma (Lemstrova et al, 2016;Hardin et al, 2017).…”

Section: Ultrastructural Resultsmentioning

confidence: 99%

The ameliorative influence of melatonin against hepatotoxicity-induced by taxol in adult rats

Aboelwafa

Ramadan

Abdelhamid

2022

African Journal of Biological Sciences

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Cancer is a worldwide growing health problem caused expanding utilization of chemotherapy which is still the most popular and first-line method of treating malignancies. The current study aimed to use histological, histomorphometrical, immunohistochemical, and ultrastructural protocols to evaluate the hepatotoxic effect of Taxol (TXL) and the ameliorative influence of melatonin (MLT) against toxic impacts in the liver of adult rats. Fifty rats were used and randomly divided into four groups: control, sham, TXL (7.5 mg kg 1 i.p.), MLT (10 mg kg -1 i.p.) and MLT+TXL (10 mg kg -1 + 7.5 mg kg -1 i.p.) groups. The results indicated the presence of numerous histopathological, histomorphometrical, and ultrastructural changes in the hepatic tissues of TXLtreated animals including destruction of the normal building of the hepatic lobules, with marked decline in the number of intact hepatocytes, and a rise in the number of necrotic hepatic cells, centrilobular and periportal inflammatory cells, and degraded Kupffer cells, in addition to noticeable apoptosis which was represented immunohistochemically by marked elevation in P53 and casapase3 (Cas3), and diminution in Bcl-2 immunoreactivities. Also, strong CD163 immunoreactivity was seen in TXL-treated rats. Nevertheless, co-administration of MLT with TXL reversed most of the histological and ultrastructural alterations triggered by TXL in rats. Moreover, MLT revealed a diminished effect against liver apoptosis and inflammation caused by TXL which was represented by elevation of immunoexpression of Bcl-2 and decreased immunoexpression of P53, Cas3, and CD163. In Conclusion, the present study proved that MLT has ameliorative impact against TXL-triggered hepatic toxicity through its antioxidant, anti-inflammatory and anti-apoptotic properties.

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“…This effect is also attributed to the generation of oxygen free radicals that leads to the peroxidation of lipids, oxidation of sulfur-containing proteins, DNA damage, and oxidative stress in mitochondria leading to reduced availability of ATP 31 . The sperm motility is impaired due to the reduced amount of ATP 32 . The toxic effect of CP on sperm count, sperm motility, and sperm defects were prevented by B. sacra extract.…”

Section: Discussionmentioning

confidence: 99%

Frankincense extract protects against testicular damage through augmentation of antioxidant defense mechanisms and modulation of apoptotic genes expression

Alharbi

Asad

Abdelsalam

et al. 2022

Sci Rep

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Frankincense (Boswellia sacra Fluck.,) is traditionally used in the treatment of altered male fertile potential in several countries. This study evaluated the cytoprotective action of B. sacra oleo gum resin extract against cyclophosphamide (CP) induced testicular toxicity in rats (in-vivo) and lipopolysaccharide (LPS) induced cytotoxicity in human Leydig cells (in-vitro). The methanolic extract of B. sacra was standardized for the presence of different boswellic acids using high-performance liquid chromatography (HPLC) and volatile constituents in the extract were detected by gas chromatography–mass spectrometry (GC–MS). Two doses of B. sacra extract were used in the in-vivo study. The HPLC analysis showed that extract contains about 36% w/w of total boswellic acids and GC–MS analysis revealed the presence of another 71 different constituents. Administration of B. sacra extract to rats increased serum testosterone levels, antioxidant enzyme activities, and sperm count with improved sperm quality in a dose-dependent manner, when compared to CP treated animals. Boswellia sacra extract also protected the human Leydig cells against LPS-induced damage and increased the expression of the Bcl-2 gene along with a decrease in caspase-3 gene expression. The results of this study show that B. sacra extract has a protective effect on the male reproductive system.

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Effects of chemotherapeutic agents on male germ cells and possible ameliorating impact of antioxidants

Cited by 29 publications

References 133 publications

British Society for Rheumatology guideline on prescribing drugs in pregnancy and breastfeeding: immunomodulatory anti-rheumatic drugs and corticosteroids

British Society for Rheumatology guideline on prescribing drugs in pregnancy and breastfeeding: immunomodulatory anti-rheumatic drugs and corticosteroids

The ameliorative influence of melatonin against hepatotoxicity-induced by taxol in adult rats

Frankincense extract protects against testicular damage through augmentation of antioxidant defense mechanisms and modulation of apoptotic genes expression

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