Effects of chemical composition on the in vitro degradation of micelles prepared from poly(D,L-lactide-co-glycolide)-poly(ethylene glycol) block copolymers

Su, Feng; Li, Chenglong; Li, Rongye; Peng, Yun; Wang, Yuandou; Xi, Laishun; Chen, Yangsheng; Li, Suming

doi:10.1016/j.polymdegradstab.2018.11.007

Cited by 10 publications

(9 citation statements)

References 24 publications

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“…It is thus difficult to load valsartan in the hydrophobic core of micelles at physiological pH because of its good water solubility. Nevertheless, the blank micelle solution has an acidic pH of about 4 due to the presence of residual lactide/glycolide monomers, which are hydrolyzed to acidic species, in agreement with previous work 30 . Under these conditions, valsartan is unionized and has poor water‐solubility and high lipophilicity 3 .…”

Section: Resultssupporting

confidence: 89%

“…PLGA‐PEG diblock copolymers were synthesized by ring‐opening polymerization of D , L ‐lactide, and glycolide in the presence of mPEG as macro‐initiator and stannous octoate (Sn[Oct] 2 ) as a catalyst, as described previously 30 . Typically, mPEG, D , L ‐lactide, and glycolide with predetermined monomer ratios were added into a polymerization ampoule, followed by addition of stannous octoate (0.1 wt%).…”

Section: Methodsmentioning

confidence: 99%

“…Drug‐free micelles of PLGA‐PEG diblock copolymers were prepared by using the direct dissolution method 30 . 10 mg copolymer was dissolved in 10 ml distilled water to obtain a micelle solution at a concentration of 1 mg/ml.…”

Section: Methodsmentioning

confidence: 99%

“…It was shown that PLGA‐PEG micelles present good cyto‐ and hemocompatibility in vitro, with no toxicity in vivo to embryos growth. The effects of chemical composition on micelle degradation were also evaluated 30 . Micelles with shorter PLGA blocks degrade more rapidly than those with longer PLGA blocks.…”

Section: Introductionmentioning

confidence: 99%

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Self‐assembled micelles prepared from poly(D,L‐lactide‐co‐glycolide)‐poly(ethylene glycol) block copolymers for sustained release of valsartan

Zhu

Zhang

Wang

et al. 2020

Polymers for Advanced Techs

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Poly(D,L‐lactide‐co‐glycolide)‐poly(ethylene glycol) (PLGA‐PEG) diblock copolymers with different compositions were synthesized by ring‐opening polymerization of D,L‐lactide and glycolide, using monomethoxy PEG as macro‐initiator. The resulting copolymers were characterized by nuclear magnetic resonance, gel permeation chromatography, and critical micelle concentration analyses. Self‐assembly of the copolymers yielded aggregates of different architectures, including spherical micelles and a mixture of spherical and worm‐like micelles with Y‐junctions. The self‐assembled architecture depends on both the hydrophilic/hydrophobic balance and the molar mass of copolymers. Valsartan, a widely used drug in the treatment of hypertension, was loaded in micelles using a co‐solvent evaporation method. High drug‐loading content was obtained for worm‐like micelles. in vitro drug release was performed at 37°C in pH 7.4 phosphate‐buffered saline. An initial burst release is detected in all cases, followed by slower release up to 9 days. The overall release rate is strongly dependent on the degradation of micelles. Copolymers with short PLGA blocks exhibit faster drug release due to faster degradation of micelles, and worm‐like micelles present slower drug release as compared to spherical ones. Therefore, PLGA‐PEG copolymer micelles with high drug‐loading capacity, different architectures, and variable drug release rates could be most attractive for sustained delivery of valsartan.

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Section: Resultssupporting

confidence: 89%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Self‐assembled micelles prepared from poly(D,L‐lactide‐co‐glycolide)‐poly(ethylene glycol) block copolymers for sustained release of valsartan

Zhu

Zhang

Wang

et al. 2020

Polymers for Advanced Techs

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“…The last category has attracted particular attention as it is associated with simple molecular designs, facile synthetic processes and inexpensive raw materials. Polymers based on lactic acid exhibit a suitable balance between physical properties and biodegradability, and these properties can be tuned as required by blending with other polymers or by synthesizing copolymers . Biodegradable polymers can also be employed as functional materials, such as in drug delivery systems, and the preparation of microcapsules made of biodegradable polymers has been studied using the unique properties of supercritical carbon dioxide (scCO 2 ) …”

Section: Introductionmentioning

confidence: 99%

Changes in the morphology of poly( l ‐lactide‐ ran ‐δ‐valerolactone) following supercritical carbon dioxide processing

Tsutsumi

Ishikawa

Takahashi

et al. 2019

Polymer Crystallization

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Biodegradable polymers can be employed as controlled‐release materials when processed with supercritical carbon dioxide (scCO2), and l‐lactide (L‐LA) random copolymers are useful in such applications. In the present work, poly(l‐lactide‐ran‐δ‐valerolactone) (poly(L‐LA‐ran‐VL)) copolymers, which do not melt during scCO2 processing above 80°C, were synthesized. The thermal properties, crystallinity, and polymer chain structures of these materials were evaluated before and after processing at temperatures from 60°C to 120°C and 14 MPa. An efficient one‐pot process (termed azeotropic‐combined one‐pot polymerization or ACOP) produced poly(L‐LA‐ran‐VL) or poly(L‐LA) in good yields and high molecular weights, and poly(L‐LA) with an Mn of 8.20 × 104 was obtained without the use of an inert gas. Poly(L‐LA‐ran‐VL) composed a 73/27 ratio of L‐LA and VL had a relatively high molecular weight despite its lower L‐LA content, and its Tm and ΔHm were decreased only slightly compared to that of poly(L‐LA). Both ΔHm and crystallinity were found to increase with increases in the scCO2 processing temperature, especially at 120°C. Although the degree of crystallinity increased with increasing L‐LA content, the ΔHm of the 83/17 specimen (which had the lowest Mn) was higher than that of the 91/9 sample. Before processing, the 73/27 copolymer had the highest haze value while the 91/9 specimen had the lowest, and there was a linear relationship between the haze and crystallinity of each copolymer after processing at all temperatures. The infrared spectrum of the 73/27 copolymer prior to scCO2 processing exhibited a maximum absorbance at 1756 cm−1, and this peak was shifted to higher wavenumber with increases in the processing temperature. Thus, infrared spectroscopy could be used to assess increases in crystallinity following scCO2 processing.

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Designing Molecular Building Blocks for Functional Polymersomes

Rijpkema

Toebes

Maas

et al. 2019

Israel Journal of Chemistry

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In recent years various polymeric vesicles have been reported that show promising results for drug delivery applications, nanomotors and/or nanoreactors. These polymeric vesicles can be assembled from many different materials and various coupling reactions have been applied for functionalization of the vesicles. However, the designs reported are still rather simple, as it is challenging to mimic biological complex systems. In this review we focus on the properties of widely used hydrophobic polymers to better understand polymersome properties for various applications. Examples are shown of how researchers have used and modulated block‐copolymers and their properties to their advantage. Furthermore, an overview of possible end group functionalizations of nanoparticles is reported, giving insight in recent developments of smart nanoparticles for biomedical applications.

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Effects of chemical composition on the in vitro degradation of micelles prepared from poly(D,L-lactide-co-glycolide)-poly(ethylene glycol) block copolymers

Cited by 10 publications

References 24 publications

Self‐assembled micelles prepared from poly(D,L‐lactide‐co‐glycolide)‐poly(ethylene glycol) block copolymers for sustained release of valsartan

Self‐assembled micelles prepared from poly(D,L‐lactide‐co‐glycolide)‐poly(ethylene glycol) block copolymers for sustained release of valsartan

Changes in the morphology of poly( l ‐lactide‐ ran ‐δ‐valerolactone) following supercritical carbon dioxide processing

Designing Molecular Building Blocks for Functional Polymersomes

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