Effects of Charge Density and Thermal History on the Morphologies of Spontaneously Formed Unilamellar Vesicles

Abstract

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Access to Different Nanostructures via Self‐Assembly of Thiourea‐Containing PEGylated Amphiphiles

“…Upon changing the hydrophobic tail from linear alkanes ( 2A and 2B ) to dodecanol ( 2C ) resulted in lamellar disks of diameters ranging from about 12 to 20 nm (Figure 1). Unlike spherical micelles and rod‐like micelles, disks are not frequently encountered 3, 33–40. There are only a handful of reported systems that are capable of forming disk morphology as they are found to be formed under very specific compositions and/or conditions 34–37, 39.…”

“…Disk‐like micelles formed by lipids have been demonstrated to transform into unilamellar vesicles by Nieh and co‐workers 33–35. In their detailed studies, by using multitude of characterization techniques, they identified that by thermal treatment, bicelles transformed to vesicles and the disk‐like micelles were found to be the key intermediate.…”

Bicelles: Lipid Nanostructured Platforms with Potential Dermal Applications

“…In fact, systems formed by long‐alkyl‐chain phospholipids and DHPC have been reported to produce reasonably monodisperse unilamellar vesicles that are thermodynamically stable, with radii ranging from 10 to 40 nm 67–70. Several kinetic studies have shown that discoidal bicelle morphology is a precursor to small‐vesicle morphology 70, 71. DHPC molecules solubilize the DMPC bilayer similar to a surfactant; however, DHPC is a phospholipid with the same polar head group as DMPC.…”

Structural Versatility of Bicellar Systems and Their Possibilities as Colloidal Carriers

“…In the absence of Ln 3+ , bicelles were disk-shaped in the gel phase, and chiral nematic in the liquid crystalline phase, which were described as wormlike micelles, and at higher temperatures were multilamellar vesicles [27]. Additionally, recent studies have demonstrated that inclusion of small amount of charged lipids eliminated the appearance of the worm-like or ribbon phase [31] Hereafter, the use of the term bicelle in most studies refers only to the sample composition and not to the disk-shaped morphology. A comparative study of alignable and non-alignable bicelles associated to the temperature changes of the system could be helpful to clarify the morphological transitions involved in this process.…”