Effects of Changing the Type of H₂-Blocker in the Treatment of H₂-Blocker-Resistant Ulcers: Comparison of Roxatidine Acetate Hydrochloride and other H₂-Blockers

Abstract

The efficacy of switching from one type of H2-receptor antagonist (H2-blocker) to another, in the treatment of H2-blocker-resistant ulcers was investigated using H2-blockers with five-membered rings (five-membered-ring agents)--such as cimetidine, ranitidine and famotidine--and an H2-blocker with a six-membered ring, roxatidine. By switching from a five-membered-ring agent to roxatidine in the treatment of five-membered-ring resistant ulcers (study I), gastric ulcers were healed in nine of 19 patients (47%) and duodenal ulcers were healed in eight of nine patients (89%). By switching from roxatidine to one of the five-membered-ring agents in the treatment of roxatidine-resistant ulcers (study II), gastric ulcer was healed in six of 15 patients (40%), and duodenal ulcer was healed in 4 of 10 patients (40%). Particularly in the case of duodenal ulcers, the switch to treatment with roxatidine, which has a different chemical structure from the five-membered-ring agents, may be useful in the treatment of five-membered-ring-resistant ulcers.

Effect of lansoprazole versus roxatidine on prevention of bleeding and promotion of ulcer healing after endoscopic submucosal dissection for superficial gastric neoplasia

“…Roxatidine has been reported to prevent the formation of gastric mucosal lesions induced by necrotizing agents in rats [17], and it has also been shown to be as effective and safe as the other H 2 RAs for the treatment of gastric ulcers and duodenal ulcers. Particularly in duodenal ulcers, switching from H 2 RAs with a fivemembered ring to roxatidine may be useful in the treatment of ulcers resistant to treatment with five-membered-ring agents [11]. Therefore, roxatidine might be as efficacious as lansoprazole in preventing bleeding after ESD.…”

“…It is as effective and safe as the other H 2 RAs with a five-membered ring (cimetidine, ranitidine, famotidine, and nizatidine) in the treatment of gastric and duodenal ulcers, and may also be useful for the treatment of five-memberedring H 2 RA-resistant ulcers, especially duodenal ulcers [11].…”

Διερεύνηση της επίδρασης ενός τυπικού H2 - ανταγωνιστή της ισταμίνης (υδροχλωρική ρανιτιδίνη) στη διάμετρο της κόρης υπό φωτοπικές και σκοτοπικές συνθήκες με το ηλεκτρονικό κορόμετρο του Colvard

“…Η κλινική αποτελεσματικότητα και η συνεχής έρευνα έχει οδηγήσει σε ανακάλυψη νέων ουσιών της ομάδας αυτής, όπως τη ροξαταδίνη, με ακόμη καλύτερα φαρμακολογικά χαρακτηριστικά (73. Yasutake K et al, 1998).…”