Effects of changes in estimated left ventricular filling pressure on functional and structural reverse remodelling of the left atrium

Abstract

S339 these agents on plaque composition remains poorly characterised. Frequency-optical coherence tomography (FD-OCT) permits visualisation of plaque microstructures in vivo. The current study compared FD-OCT derived plaque microstructures in patients treated with high-dose rosuvastatin and atorvastatin. Methods: 117 non-culprit lipid plaques in 134 patients with coronary artery disease, undergoing percutaneous coronary intervention, who received high-dose rosuvastatin (mean dose 21.5 mg) or atorvastatin (mean dose 68.7 mg) were characterized by FD-OCT. Clinical demographics and FD-OCT derived plaque microstructures were compared. Results: Rosuvastatin-treated patients were more likely to be obese (BMI; 34.4 vs. 29.5 kg/m 2 , p=0.003), have hypertension (69 vs. 38%, p=0.03) and metabolic syndrome (91.6 vs. 48.2%, p-0.004) and had a trend to lower levels of low-density lipoprotein cholesterol (1.9±0.4 vs. 2.4±0.9 mmol/l, p=0.09). FD-OCT imaging revealed that non-culprit lipid plaques in rosuvastatin-treated patients were less likely to harbor microchannels (7 vs. 46%, p=0.02) and had a smaller maximum arc of lipid (163±109 vs. 211±95 • , p=0.08), although this just failed to meet statistical significance. Fibrous cap thickness did not differ between the groups (124±73 vs. 109±71m, p=0.49). Following adjustment for clinical demographics, rosuvastatin use continued to associate with a lower prevalence of microchannels (p=0.03). Conclusions: Individual high-intensity statins may have differing effects on plaque microstructures at non-culprit lesions on FD-OCT imaging. Whether this translates to a more favourable effect on clinical events remains to be determined.