Effects of chamomile tea on inflammatory markers and insulin resistance in patients with type 2 diabetes mellitus

Abstract

Aim:The purpose of this study was to evaluate the effects of chamomile tea consumption inflammatory markers and insulin resistance in subjects with type 2 diabetes mellitus (T2DM).Methods: This single-blind randomized controlled clinical trial was conducted on 64 individuals with T2DM (males and females) aged between 30 and 60 years. The intervention group (n=32) consumed chamomile tea (3g/150 mL hot water) 3 times per day immediately after meals for 8 weeks. The control group (n=32) followed a water regimen for the same intervention period. Fasting blood samples, anthropometric measurements and 3-day, 24-h dietary recalls were collected at the baseline and at the end of the trial. Data were analysed by independent t test, paired t test, Pearson correlation test, and analysis of covariance.Results: Analysis of covariance showed that tumour necrosis factor-α (TNFα) and high sensitive C-reactive protein (hs-CRP) levels and homeostatic model assessment for insulin resistance (HOM-IR) were significantly decreased by 4.87%, 57.20% and 23.60% respectively in chamomile group compared with these variables in control group at the end of the intervention (all p<0.05). There was significant positive correlation between the changes of serum TNFα and hs-CRP with HOMA-IR (r=0.567, p<0.001 and r= 0.520, p<0.001, respectively) in chamomile tea group at the end of the study. Conclusion::Short term intake of chamomile tea has beneficial effects on inflammatory markers and insulin resistance in patients with T2DM. Higher larger sample population and a longer intervention period may be required to show significant clinical improvements.

Integrating experimental model, LC-MS/MS chemical analysis, and systems biology approach to investigate the possible antidiabetic effect and mechanisms of Matricaria aurea (Golden Chamomile) in type 2 diabetes mellitus

“…In agreement with our experimental results and network predictions, a previous study showed that chamomile was able to mitigate inflammation and reduce the expression of inflammatory genes in the liver of insulin-resistant obese mice (Weidner et al, 2013). In addition, previous studies showed that chamomile reduces the inflammatory markers in the blood of animal models and human type 2 diabetes patients (Shelbaya, 2017;Nargesi et al, 2018;Zemestani et al, 2018). Furthermore, several studies showed the effectiveness of chamomile in mitigating inflammation in various inflammatory disease models, including macrophages, brain, skin, colon, and adipocytes.…”