Effects of cevimeline on salivation and thirst in conscious rats

Sato, Nao; Ono, Kentaro; Haga, Kensuke; Yokota, Makoto; Inenaga, Kiyotoshi

doi:10.1016/j.archoralbio.2006.09.002

Cited by 12 publications

(6 citation statements)

References 14 publications

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“…Binding sites for stanniocalcin, a circulating hormone that regulates calcium/phosphate homeostasis, have recently been identified in the SFO [and hypothalamic projections sites involved in fluid homeostasis (SON)], further implicating action of this hormone at the SFO in the regulation of fluid homeostasis, electrolyte balance, and cardiovascular regulation (95). Peripheral administration of pilocarpine, a muscarinic receptor agonist, has been shown to facilitate drinking behavior in rats (38,106). Recent studies revealing c-fos immunoreactivity in SFO and patch-clamp recording techniques demonstrating that pilocarpine directly depolarizes SFO neurons by suppressing the release of an inhibitory transmitter (53), suggest that SFO may mediate the dipsogenic effects of exogenous pilocarpine administration.…”

Section: Anatomical Features Of the Sfomentioning

confidence: 99%

Circulating signals as critical regulators of autonomic state—central roles for the subfornical organ

Smith

Ferguson

2010

American Journal of Physiology-Regulatory, Integrative and Comp

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To maintain homeostasis autonomic control centers in the hypothalamus and medulla must respond appropriately to both external and internal stimuli. Although protected behind the blood-brain barrier, neurons in these autonomic control centers are known to be influenced by changing levels of important signaling molecules in the systemic circulation (e.g., osmolarity, glucose concentrations, and regulatory peptides). The subfornical organ belongs to a group of specialized central nervous system structures, the circumventricular organs, which are characterized by the lack of the normal blood-brain barrier, such that circulating lipophobic substances may act on neurons within this region and via well-documented efferent neural projections to hypothalamic autonomic control centers, influence autonomic function. This review focuses on the role of the subfornical organ in sensing peripheral signals and transmitting this information to autonomic control centers in the hypothalamus.

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Section: Anatomical Features Of the Sfomentioning

confidence: 99%

Circulating signals as critical regulators of autonomic state—central roles for the subfornical organ

Smith

Ferguson

2010

American Journal of Physiology-Regulatory, Integrative and Comp

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“…A 24-gauge stainless-steel guide cannula for ICV injection of drugs was implanted in each rat under sodium pentobarbital anesthesia (60 mg/kg, intraperitoneally injected), as described in the authors' earlier study [9]. The cannulas were implanted in the lateral cerebral ventricles, 0.8 mm caudal to the bregma, 1.4 mm right lateral to midline and 2.0 mm below the dura matter.…”

Section: Icv Injectionmentioning

confidence: 99%

Central injection of galanin inhibits angiotensin II-induced responses in rats

Hirase

Ono²,

Yamashita³

et al. 2008

NeuroReport

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Galanin inhibits electrical activation of angiotensin II-sensitive neurons in the subfornical organ, which is related to angiotensin II-induced drinking behavior and pressor responses. In this study, the authors investigated whether intracerebroventricular injection of galanin in conscious rats inhibits the responses. Water intake following intracerebroventricular injection of angiotensin II at 100 pmol was inhibited significantly by coinjection of galanin at over 25 pmol, although galanin alone did not affect water intake. Furthermore, angiotensin II-induced pressor responses were inhibited significantly by coinjection of galanin at 50 pmol while galanin alone elicited slight pressor responses. These results suggest that galanin inhibits angiotensin II-induced physiological responses.

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“…At least in theory, cevimeline will produce less side‐effects compared with pilocarpine because of the higher affinity for the muscarinic receptors located in the salivary glands. A limited number of human clinical trials in the efficacy of cevimeline and pilocarpine to increase the production of saliva and the side‐effects have been performed with no conclusive results …”

Section: Introductionmentioning

confidence: 99%