Effects of cetylpyridinium-montmorillonite, as alternative to antibiotic, on the growth performance, intestinal microflora and mucosal architecture of weaned pigs

Yao, Ke; Song, Zehe; Xiao, Kan; Lai, Tiantian; Lu, Jianjun; Hu, Caihong

doi:10.1016/j.anifeedsci.2014.10.010

Cited by 19 publications

(16 citation statements)

References 30 publications

(48 reference statements)

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“…The villus crypt is considered as villus factory. The increase in crypt depth indicates fast tissue turnover and high demand for new tissue, which are generally associated with decline in nutrient digestion and absorption capacity (37,38). Studies have confirmed that weaning is associated with villus atrophy and crypt hyperplasia (3,39).…”

Section: Discussionmentioning

confidence: 99%

Effect of the Single and Combined Use of Curcumin and Piperine on Growth Performance, Intestinal Barrier Function, and Antioxidant Capacity of Weaned Wuzhishan Piglets

et al. 2020

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This study was conducted to evaluate effects of the single and combined use of curcumin (CUR) and piperine (PIP) on performance, intestinal barrier function, and antioxidant capacity of weaned piglets. A total of 50 Wuzhishan piglets weaned at 35 days of age were randomly assigned to five groups receiving a corn-soybean basal diet (CON), the basal diet supplemented with 50 mg/kg piperine, 200 mg/kg curcumin (low-CUR), 200 mg/kg curcumin + 50 mg/kg piperine (PIP + CUR), and 300 mg/kg curcumin (high-CUR), respectively. The results showed that the feed/gain ratio (F/G) and plasma d-lactate and diamine oxidase activity (DAO) of the CUR + PIP and high-CUR groups were lower than those of the CON group (all P < 0.05), while the jejunum and ileum villus height, the villus height/crypt depth ratio, and the messenger RNA (mRNA) expression levels of occludin, claudin-1, and zonula occluden-1 in jejunal and ileal mucosa were higher in the CUR + PIP and high-CUR groups than in the CON group (all P < 0.05). Moreover, the piglets in the CUR + PIP and high-CUR groups had higher serum and intestinal mucosa activity of superoxide dismutase and glutathione peroxidase and lower malonaldehyde concentration than piglets in the CON group (all P < 0.05). The above parameters were not significantly different between the CUR + PIP and high-CUR groups (P > 0.05). In conclusion, the combination of CUR and PIP seemed to be as advantageous as high-CUR to piglets, but it was more effective than the single use of CUR and PIP. These data indicated that the basal diet supplemented with CUR + PIP or high-CUR could improve the intestinal permeability and suppress oxidative stress of weaned Wuzhishan piglets.

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Section: Discussionmentioning

confidence: 99%

Effect of the Single and Combined Use of Curcumin and Piperine on Growth Performance, Intestinal Barrier Function, and Antioxidant Capacity of Weaned Wuzhishan Piglets

et al. 2020

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“…Some researchers have reported modified MMT materials with antibacterial activity. For example, silver, copper, and zinc ions have been immobilized on MMT [4][5][6][7][8][9], and cetylpyridinium, cetyltrimethylammonium [10][11][12], tetradecyltrimethylammonium [13], chitosan [14,15], and chlorhexidine acetate [16] have been intercalated into the MMT layers. In addition, pharmacology studies have revealed that MMT can adsorb to bacteria such as Escherichia coli (E. coli), Staphylococcus aureus (S. aureus), and immobilized cell toxins [17,18].…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial Nanocomposites Prepared from Montmorillonite/Ag⁺/Quaternary Ammonium Nitrate

Zhang

Chen

et al. 2018

Journal of Nanomaterials

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Nanocomposites of Ag with organic montmorillonite (Ag-OMMT), Ag with montmorillonite (Ag-MMT), and organic montmorillonite (OMMT) were successfully prepared via a one-step solution-intercalated method. Sodium MMT, silver nitrate, and dimethyl octadecyl hydroxy ethyl ammonium nitrate were used as precursors. X-ray diffraction, Fourier transform infrared spectroscopy, transmission electron microscopy, and energy dispersive spectroscopy analyses confirmed that the MMT layers were intercalated, and Ag + was partly reduced to silver nanoparticles with diameters within 10-20 nm in Ag-OMMT. The decomposition temperature of the organic cations in OMMT and Ag-OMMT increased to 220 ∘ C, as revealed by differential scanning calorimetrythermogravimetric analysis. The antimicrobial activity of the nanocomposites was tested by measuring the minimum inhibitory concentration (MIC) and killing rate. The MICs of Ag-OMMT against Staphylococcus aureus, Escherichia coli, and Candida albicans were 0.313, 2.5, and 0.625 mg/mL, respectively. Because of the presence of quaternary ammonium nitrate, Ag-OMMT has a better MIC against Gram-positive bacteria compared to Gram-negative bacteria and fungi. OMMT did not show antimicrobial activity against Escherichia coli and Candida albicans. In 2 h, 0.0125 mg/mL Ag-OMMT could kill 100% of S. aureus, E. coli, and C. albicans in solution, and Ag-MMT could kill 99.995% of S. aureus, 90.15% of E. coli, and 93.68% of C. albicans. These antimicrobial functional nanocomposites have the potential for application in the area of surface decoration films.

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“…In the study of Ke et al. ( 2014 ), a total of 150 weaned piglets (Duroc × Landrace × Yorkshire, 21 days of age, BW 6.2 kg) were allocated to five dietary treatments and distributed in five replicate pens per treatment with six animals each. Two were the relevant treatments obtained from a basal diet which was either not supplemented (control) or supplemented with chlortetracycline (unspecified form) at a concentration of 75 mg/kg feed.…”

Section: Assessmentmentioning

confidence: 99%

Maximum levels of cross‐contamination for 24 antimicrobial active substances in non‐target feed. Part 12: Tetracyclines: tetracycline, chlortetracycline, oxytetracycline, and doxycycline

Koutsoumanis¹,

Allende²,

Álvarez‐Ordóñez³

et al. 2021

EFS2

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The specific concentrations of tetracycline, chlortetracycline, oxytetracycline and doxycycline in nontarget feed for food-producing animals, below which there would not be an effect on the emergence of, and/or selection for, resistance in bacteria relevant for human and animal health, as well as the specific antimicrobial concentrations in feed which have an effect in terms of growth promotion/increased yield were assessed by EFSA in collaboration with EMA. Details of the methodology used for this assessment, associated data gaps and uncertainties are presented in a separate document. To address antimicrobial resistance, the Feed Antimicrobial Resistance Selection Concentration (FARSC) model developed specifically for the assessment was applied. The FARSC for these four tetracyclines was estimated. To address growth promotion, data from scientific publications obtained from an extensive literature review were used. Levels in feed that showed to have an effect on growth promotion/increased yield were reported for tetracycline, chlortetracycline, oxytetracycline, whilst for doxycycline no suitable data for the assessment were available. Uncertainties and data gaps associated with the levels reported were addressed. It was recommended to perform further studies to supply more diverse and complete data related to the requirements for calculation of the FARSC for these antimicrobials.

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Effects of cetylpyridinium-montmorillonite, as alternative to antibiotic, on the growth performance, intestinal microflora and mucosal architecture of weaned pigs

Cited by 19 publications

References 30 publications

Effect of the Single and Combined Use of Curcumin and Piperine on Growth Performance, Intestinal Barrier Function, and Antioxidant Capacity of Weaned Wuzhishan Piglets

Effect of the Single and Combined Use of Curcumin and Piperine on Growth Performance, Intestinal Barrier Function, and Antioxidant Capacity of Weaned Wuzhishan Piglets

Antimicrobial Nanocomposites Prepared from Montmorillonite/Ag⁺/Quaternary Ammonium Nitrate

Maximum levels of cross‐contamination for 24 antimicrobial active substances in non‐target feed. Part 12: Tetracyclines: tetracycline, chlortetracycline, oxytetracycline, and doxycycline

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Effects of cetylpyridinium-montmorillonite, as alternative to antibiotic, on the growth performance, intestinal microflora and mucosal architecture of weaned pigs

Cited by 19 publications

References 30 publications

Effect of the Single and Combined Use of Curcumin and Piperine on Growth Performance, Intestinal Barrier Function, and Antioxidant Capacity of Weaned Wuzhishan Piglets

Effect of the Single and Combined Use of Curcumin and Piperine on Growth Performance, Intestinal Barrier Function, and Antioxidant Capacity of Weaned Wuzhishan Piglets

Antimicrobial Nanocomposites Prepared from Montmorillonite/Ag+/Quaternary Ammonium Nitrate

Maximum levels of cross‐contamination for 24 antimicrobial active substances in non‐target feed. Part 12: Tetracyclines: tetracycline, chlortetracycline, oxytetracycline, and doxycycline

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Antimicrobial Nanocomposites Prepared from Montmorillonite/Ag⁺/Quaternary Ammonium Nitrate